✓Accurate and fast localization of the subthalamic nucleus (STN) during intraoperative electrophysiological monitoring can improve the outcome of deep brain stimulation surgery. The authors show a simple method of detecting the STN that is based on an analysis of the high-frequency (> 500 Hz) background (HFB) activity of neurons. The HFB reflects multiunit spiking activity close to the recording electrode, and its characteristic profile, which is higher in the STN than in neighboring structures, and facilitates delineation of both the dorsal and ventral STN borders.
Abbreviations used in this paper:ANOVA = analysis of variance; DBS = deep brain stimulation; HFB = high-frequency background; MER = microelectrode recording; MPTP = 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MR = magnetic resonance; SN = substantia nigra; STN = subthalamic nucleus.
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