Characterization and correction of distortions in stereotactic magnetic resonance imaging for bilateral subthalamic stimulation in Parkinson disease

Restricted access

Object. High-frequency stimulation of the subthalamic nucleus (STN) is effective for treating refractory idiopathic Parkinson disease (PD). In stereotactic conditions magnetic resonance (MR) imaging is used by many teams to perform preoperative targeting of the STN. The goal of this study was to analyze and correct the geometrically observed MR imaging acquisitions used for targeting of the STN.

Methods. A dedicated phantom of known geometry was used. The authors calculated existing shifts between measured points and theoretically defined points on the same T1- and T2-weighted sequences used to target the STN. A shifting volume was built to correct the phantom images and images acquired preoperatively in 13 patients with PD. A quantitative study of the correction was conducted using the phantom images and acquisitions acquired in these patients. To quantify the distortion corrections, the authors segmented the lateral ventricles and calculated the overlap of the corrected and uncorrected values between T1 and T2 segmentation.

The authors found that the distortions were greater in the direction of slice selection and frequency encoding and weaker on three-dimensional T1-weighted acquisitions. On T2-weighted acquisitions, the maximum shifts were 2.19 mm in the frequency-encoding direction and 3.81 mm in slice selection. The geometrical distortion was significantly reduced and smaller than pixel size after distortion correction. Assessment of the patients' scans showed that the mean ventricular overlap was 76% before and 94% after correction.

Conclusions. The authors found that significant distortions can be observed on T2-weighted images used to demonstrate the STN. These distortions can be corrected using appropriate software.

Article Information

Address reprint requests to: Carole Menuel, Ph.D., 83–47 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France. email: carole.menuel@chups.jussieu.fr.

© AANS, except where prohibited by US copyright law.

Headings

Figures

  • View in gallery

    Phantom geometry. Left: The main part of the phantom and the 10 removable plates. Center: The dimensions of the rods and plates. Right: The phantom inside the MR imaging stereotactic localizer box.

  • View in gallery

    Diagrams detailing the steps in MR image acquisition.

  • View in gallery

    A 3D reconstruction of an IR-FSPGR acquisition of the phantom. The 100 rods and the N-shaped fiducial markers can be clearly seen.

  • View in gallery

    Representation of the MR acquisition with what we have named Volboxes 1 through 5.

  • View in gallery

    Graph depicting the mean absolute values of shift between measured and theoretical center of gravity for the T1-weighted MR acquisitions.

  • View in gallery

    Graph demonstrating the mean absolute value of shift between measured and theoretical center of gravity for the uncorrected T2-weighted MR acquisitions.

  • View in gallery

    Representative MR images demonstrating the uncorrected T2-weighted sequence with vertical rods (left) and the corrected T2-weighted sequence with vertical rods (right).

  • View in gallery

    Graph depicting the mean absolute value of shift between measured and theoretical center of gravity of the corrected T2-weighted MR acquisitions.

  • View in gallery

    Fusion of the T1-weighted acquisition and the label of the lateral ventricle of the T2-weighted image obtained in two patients for one slice—the uncorrected T2-weighted label is delineated in green and the corrected label in red. Note the better registration after correction.

  • View in gallery

    Bar graph demonstrating the overlap between corrected and uncorrected T1- and T2-weighted segmentation of the lateral ventricle observed in 13 patients.

  • View in gallery

    A T2-weighted image obtained in a patient with PD, with the superimposition of the five volboxes. Note that the STN is localized in Volbox 2 where the maximal shifts are on order of 0.3 mm.

References

  • 1.

    Bejjani BDormont DPidoux BYelnik JDamier PArnulf Iet al: Bilateral subthalamic stimulation for Parkinson's disease by using three-dimensional stereotactic magnetic resonance imaging and electrophysiological guidance. J Neurosurg 92:6156252000Bejjani B Dormont D Pidoux B Yelnik J Damier P Arnulf I et al: Bilateral subthalamic stimulation for Parkinson's disease by using three-dimensional stereotactic magnetic resonance imaging and electrophysiological guidance. J Neurosurg 92:615–625 2000

    • Search Google Scholar
    • Export Citation
  • 2.

    Burchiel KJNguyen TTCoombs BDSzumoski J: MRI distortion and stereotactic neurosurgery using the Cosman-Roberts-Wells and Leksell frames. Stereotact Funct Neurosurg 66:1231361996Burchiel KJ Nguyen TT Coombs BD Szumoski J: MRI distortion and stereotactic neurosurgery using the Cosman-Roberts-Wells and Leksell frames. Stereotact Funct Neurosurg 66:123–136 1996

    • Search Google Scholar
    • Export Citation
  • 3.

    Chang HFitzpatrick JM: Geometrical image transformation to compensate for MRI distortions. Proc SPIE 1233:1161271990Chang H Fitzpatrick JM: Geometrical image transformation to compensate for MRI distortions. Proc SPIE 1233:116–127 1990

    • Search Google Scholar
    • Export Citation
  • 4.

    Chang HFitzpatrick JM: A technique for accurate magnetic resonance imaging in the presence of field inhomogeneites. IEEE Trans Med Imaging 11:3193291992Chang H Fitzpatrick JM: A technique for accurate magnetic resonance imaging in the presence of field inhomogeneites. IEEE Trans Med Imaging 11:319–329 1992

    • Search Google Scholar
    • Export Citation
  • 5.

    Dormont DCornu PPidoux BBonnet AMBiondi AOppenheim Cet al: Chronic thalamic stimulation with three-dimensional MR stereotactic guidance. AJNR 18:109311071997Dormont D Cornu P Pidoux B Bonnet AM Biondi A Oppenheim C et al: Chronic thalamic stimulation with three-dimensional MR stereotactic guidance. AJNR 18:1093–1107 1997

    • Search Google Scholar
    • Export Citation
  • 6.

    Holden MBreeuwer MMcLeish KHawkes DJKeevil SFHill DL: Higher order geometrical distortion in serial MR brain imaging in Proceedings of the International Society of Magnetic Resonance Medicine. Glasgow2001 p 742Holden M Breeuwer M McLeish K Hawkes DJ Keevil SF Hill DL: Higher order geometrical distortion in serial MR brain imaging in Proceedings of the International Society of Magnetic Resonance Medicine. Glasgow 2001 p 742

    • Search Google Scholar
    • Export Citation
  • 7.

    Holden MBreeuwer MMcLeish KHawkes DJKeevil SFHill DL: Sources and correction of higher-order geometrical distortion for serial MR brain imaging. Proc SPIE 4322:69782001Holden M Breeuwer M McLeish K Hawkes DJ Keevil SF Hill DL: Sources and correction of higher-order geometrical distortion for serial MR brain imaging. Proc SPIE 4322:69–78 2001

    • Search Google Scholar
    • Export Citation
  • 8.

    Kawanaka ATagaki M: Correction method of image distortion due to non-uniformity of static magnetic field in NMR imaging. Proc SPIE 515:1731771984Kawanaka A Tagaki M: Correction method of image distortion due to non-uniformity of static magnetic field in NMR imaging. Proc SPIE 515:173–177 1984

    • Search Google Scholar
    • Export Citation
  • 9.

    Langlois SDesvignes MConstans JMRevenu M: MRI geometric distortion: a simple approach to correcting the effects of non-linear gradient fields. J Magn Reson Imaging 9:8218311999Langlois S Desvignes M Constans JM Revenu M: MRI geometric distortion: a simple approach to correcting the effects of non-linear gradient fields. J Magn Reson Imaging 9:821–831 1999

    • Search Google Scholar
    • Export Citation
  • 10.

    Limousin PPollak PBenazzouz AHoffmann DLeBas JFBroussolle Eet al: Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation. Lancet 345:91951995Limousin P Pollak P Benazzouz A Hoffmann D LeBas JF Broussolle E et al: Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation. Lancet 345:91–95 1995

    • Search Google Scholar
    • Export Citation
  • 11.

    Ludeke KMRoschmann PTischler R: Susceptibility artefacts in NMR imaging. Magn Reson Imaging 3:3293431985Ludeke KM Roschmann P Tischler R: Susceptibility artefacts in NMR imaging. Magn Reson Imaging 3:329–343 1985

    • Search Google Scholar
    • Export Citation
  • 12.

    Malandain GFernandez-Vidal SRocchisani JM: Mise en correspondance d'objets 3D par une méthode physique: application a l'imagerie médicale. INRIA:24531995Malandain G Fernandez-Vidal S Rocchisani JM: Mise en correspondance d'objets 3D par une méthode physique: application a l'imagerie médicale. INRIA:2453 1995

    • Search Google Scholar
    • Export Citation
  • 13.

    Maurer CR JrAboutanos GBDawant BMGadamsetty SMargolin RAMaciunas RJet al: Effect of geometrical distortion correction in MR on image registration accuracy. J Comp Assist Tomogr 20:6666791996Maurer CR Jr Aboutanos GB Dawant BM Gadamsetty S Margolin RA Maciunas RJ et al: Effect of geometrical distortion correction in MR on image registration accuracy. J Comp Assist Tomogr 20:666–679 1996

    • Search Google Scholar
    • Export Citation
  • 14.

    Michiels JBosmans HPelgrims PVandermeulen DGybels JMarchal Get al: On the problem of geometric distortion in magnetic resonance images for stereotactic neurosurgery. Magn Reson Imaging 12:7497651994Michiels J Bosmans H Pelgrims P Vandermeulen D Gybels J Marchal G et al: On the problem of geometric distortion in magnetic resonance images for stereotactic neurosurgery. Magn Reson Imaging 12:749–765 1994

    • Search Google Scholar
    • Export Citation
  • 15.

    Pollak PBenabid ALimousin PBenazzouz A: Chronic intracerebral stimulation in Parkinson's disease. Adv Neurol 74:21322019997Pollak P Benabid A Limousin P Benazzouz A: Chronic intracerebral stimulation in Parkinson's disease. Adv Neurol 74:213–220 19997

    • Search Google Scholar
    • Export Citation
  • 16.

    Schad LLott SSchmitt FSturm VLorenz WJ: Correction of spatial distortion in MR imaging: a prerequisite for accurate stereotaxy. J Comput Assist Tomogr 11:4995051987Schad L Lott S Schmitt F Sturm V Lorenz WJ: Correction of spatial distortion in MR imaging: a prerequisite for accurate stereotaxy. J Comput Assist Tomogr 11:499–505 1987

    • Search Google Scholar
    • Export Citation
  • 17.

    Sekihara KMatsui SKohno H: A new method of measuring static field distribution using modified Fourier NMR imaging. J Phys E Sci Instrum 20:4164191987Sekihara K Matsui S Kohno H: A new method of measuring static field distribution using modified Fourier NMR imaging. J Phys E Sci Instrum 20:416–419 1987

    • Search Google Scholar
    • Export Citation
  • 18.

    Sumanaweera TSAdler JR JrNapel SGlover GH: Characterization of spatial distortion in magnetic resonance imaging and its implications for stereotactic surgery. Neurosurgery 35:6967041994Sumanaweera TS Adler JR Jr Napel S Glover GH: Characterization of spatial distortion in magnetic resonance imaging and its implications for stereotactic surgery. Neurosurgery 35:696–704 1994

    • Search Google Scholar
    • Export Citation
  • 19.

    Sumanaweera TSGlover GSong SAdler JNapel S: Quantifying MRI geometric distortion in tissue. Magn Reson Med 31:40471994Sumanaweera TS Glover G Song S Adler J Napel S: Quantifying MRI geometric distortion in tissue. Magn Reson Med 31:40–47 1994

    • Search Google Scholar
    • Export Citation
  • 20.

    Thévenaz PUnser M: Geometric aspects in 3D biomedical image processing. Bulletin ASMT/SGMT 22:5101998Thévenaz P Unser M: Geometric aspects in 3D biomedical image processing. Bulletin ASMT/SGMT 22:5–10 1998

    • Search Google Scholar
    • Export Citation
  • 21.

    Voges JVolkmann JAllert NLehrke RKoulousakis AFreund HJet al: Bilateral high-frequency stimulation in the subthalamic nucleus for the treatment of Parkinson disease: correlation of therapeutic effect with anatomical electrode position. J Neurosurg 96:2692792002Voges J Volkmann J Allert N Lehrke R Koulousakis A Freund HJ et al: Bilateral high-frequency stimulation in the subthalamic nucleus for the treatment of Parkinson disease: correlation of therapeutic effect with anatomical electrode position. J Neurosurg 96:269–279 2002

    • Search Google Scholar
    • Export Citation
  • 22.

    Walton LHampshire AForster DMKemeny AA: A phantom study to assess the accuracy of stereotactic localization, using T1-weighted magnetic resonance imaging with the Leksell stereotactic system. Neurosurgery 38:1701781996Walton L Hampshire A Forster DM Kemeny AA: A phantom study to assess the accuracy of stereotactic localization using T1-weighted magnetic resonance imaging with the Leksell stereotactic system. Neurosurgery 38:170–178 1996

    • Search Google Scholar
    • Export Citation
  • 23.

    Walton LHampshire AForster DMKemeny AA: Stereotactic localization with magnetic resonance imaging: a phantom study to compare the accuracy obtained using two-dimensional and three-dimensional data acquisitions. Neurosurgery 41:1311391997Walton L Hampshire A Forster DM Kemeny AA: Stereotactic localization with magnetic resonance imaging: a phantom study to compare the accuracy obtained using two-dimensional and three-dimensional data acquisitions. Neurosurgery 41:131–139 1997

    • Search Google Scholar
    • Export Citation
  • 24.

    Wong TSRosenfeld D: Spin-inversion imaging: a technique for NMR imaging under magnetic fields with high field nonuniformities. IEEE Trans Med Imaging 6:1481561987Wong TS Rosenfeld D: Spin-inversion imaging: a technique for NMR imaging under magnetic fields with high field nonuniformities. IEEE Trans Med Imaging 6:148–156 1987

    • Search Google Scholar
    • Export Citation

Cited By

Metrics

Metrics

All Time Past Year Past 30 Days
Abstract Views 130 130 11
Full Text Views 144 144 2
PDF Downloads 89 89 4
EPUB Downloads 0 0 0

PubMed

Google Scholar