Endovascular coil embolization of intracranial aneurysms: important factors related to rates and outcomes of incomplete occlusion

Max K. Kole M.D. 1 , David M. Pelz M.D. 1 , Paul Kalapos M.D. 1 , Donald H. Lee M.D. 1 , Irene B. Gulka M.D. 1 and Stephen P. Lownie M.D. 1
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  • 1 Departments of Clinical Neurological Sciences and Diagnostic Radiology and Nuclear Medicine, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada; Departments of Radiology and Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania; and Departments of Neurological Surgery and Diagnostic Radiology, Henry Ford Hospital, Detroit, Michigan
DOI:
https://doi.org/10.3171/jns.2005.102.4.0607
Online Publication Date:
Apr 2005
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Object. The authors report on important factors that influenced clinical and angiographically demonstrated outcomes in patients treated using coil embolization.

Methods. This study included 160 consecutive patients who underwent endovascular coil embolization for treatment of intracranial aneurysms. Univariate and multivariate logistic regression analyses were performed to assess factors that influenced the immediate posttreatment angiographic result. Cox regression analysis was used to establish factors related to the occurrence of negative events as well as a curve indicating the time to a negative event. Negative events were defined as aneurysm remnant increase, repeated treatment, rebleeding, or death during periprocedural hospitalization.

Seventy-three percent of the patients treated in this study were independent or demonstrated no deficit (Glasgow Outcome Scale [GOS] Score 4 or 5) at a mean follow up of 18.2 months. The annual delayed rebleeding rate was 0.45%. Fifty percent of patients (65 of 131) suffered a negative event within 13 ± 14 months (standard deviation). Statistically significant factors associated with the occurrence of negative events were rupture status (p = 0.0128) and immediate posttreatment angiographic result (p < 0.001). Overall clinical outcome assessed using the GOS was significantly related to the immediate posttreatment angiographic result (χ2 = 4.788, p = 0.029). The immediate posttreatment angiographic results were significantly influenced by catheter stability (p = 0.0012), aneurysm geometry (that is, simple or complex, p = 0.0053), and aneurysm neck diameter (p = 0.0205).

Conclusions. A good or excellent clinical outcome can be obtained in most patients treated using endovascular coil embolization of intracranial aneurysms. Note, however, that a significant number of patients treated using traditional platinum coils will harbor unstable aneurysm remnants or require repeated treatment.

Volume 102: Issue 4 (Apr 2005)

in Journal of Neurosurgery
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Contributor Notes

Address reprint requests to: Max Kole, M.D., Department of Neurological Surgery and Diagnostic Radiology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202. email: mkole1@hfhs.org.
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