Optical coherence tomography: a new method to assess aneurysm healing

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  • 1 Departments of Neurosurgery and Anatomic Pathology; Cole Eye Institute; Lerner Research Institute; and Diagnostic Radiology, Cleveland Clinic Foundation; and Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio
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Object. Aneurysmal subarachnoid hemorrhage affects approximately 10/100,000 people per year. Endovascular coil embolization is used increasingly to treat cerebral aneurysms and its safety and durability is rapidly developing. The long-term durability of coil embolization of cerebral aneurysms remains in question; patients treated using this modality require multiple follow-up angiography studies and occasional repeated treatments.

Methods. Optical coherence tomography (OCT) is an emerging imaging modality that uses backscattered light to produce high-resolution tomography of optically accessible biological tissues such as the eye, luminal surface of blood vessels, and gastrointestinal tract. Vascular OCT probes in the form of imaging microwires are presently available—although not Food and Drug Administration—approved—and may be adapted for use in the cerebral circulation. In this study the authors describe the initial use of OCT to make visible the neck of aneurysms created in a canine model and treated with coil embolization. Optical coherence tomography images demonstrate changes that correlate with the histological findings of healing at the aneurysm neck and thus may be capable of demonstrating human cerebral aneurysm healing.

Conclusions. Optical coherence tomography may obviate the need for subsequent follow-up angiography studies as well as aid in the understanding of endovascular tissue healing. Data in this study demonstrate that further investigation of in vivo imaging with such probes is warranted.

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Contributor Notes

Address reprint requests to: Thomas J. Masaryk, M.D., Division of Diagnostic Radiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195. email: masaryt@ccf.org.
  • 1.

    Bavinzski G, , Talazoglu V, , Killer M, , Richling B, , Gruber A, & Gross CE, et al: Gross and microscopic histopathological findings in aneurysms of the human brain treated with Guglielmi detachable coils. J Neurosurg 91:284293, 1999 Bavinzski G, Talazoglu V, Killer M, Richling B, Gruber A, Gross CE, et al: Gross and microscopic histopathological findings in aneurysms of the human brain treated with Guglielmi detachable coils. J Neurosurg 91:284–293, 1999

    • Search Google Scholar
    • Export Citation
  • 2.

    Benndorf G, , Singel S, , Proest G, , Lanksch W, & Felix R: The Doppler guide wire: clinical applications in neuroendovascular treatment. Neuroradiology 39:286291, 1997 Benndorf G, Singel S, Proest G, Lanksch W, Felix R: The Doppler guide wire: clinical applications in neuroendovascular treatment. Neuroradiology 39:286–291, 1997

    • Search Google Scholar
    • Export Citation
  • 3.

    Benndorf G, , Wellnhofer E, , Lanksch W, & Felix R: Intraaneurysmal flow: evaluation with Doppler guidewires. AJNR 17:13331337, 1996 Benndorf G, Wellnhofer E, Lanksch W, Felix R: Intraaneurysmal flow: evaluation with Doppler guidewires. AJNR 17:1333–1337, 1996

    • Search Google Scholar
    • Export Citation
  • 4.

    Bouma BE, & Tearney GJ: Clinical imaging with optical coherence tomography. Acad Radiol 9:942953, 2002 Bouma BE, Tearney GJ: Clinical imaging with optical coherence tomography. Acad Radiol 9:942–953, 2002

    • Search Google Scholar
    • Export Citation
  • 5.

    Brezinski ME, , Tearney GJ, , Bouma BE, , Boppart SA, , Hee MR, & Swanson EA, et al: Imaging of coronary artery microstructure (in vitro) with optical coherence tomography. Am J Cardiol 77:9293, 1996 Brezinski ME, Tearney GJ, Bouma BE, Boppart SA, Hee MR, Swanson EA, et al: Imaging of coronary artery microstructure (in vitro) with optical coherence tomography. Am J Cardiol 77:92–93, 1996

    • Search Google Scholar
    • Export Citation
  • 6.

    Connor SE, , West RJ, & Yates DA: The ability of plain radiography to predict intracranial aneurysm occlusion instability during follow-up of endosaccular treatment with Gugliemi detachable coils. Neuroradiology 43:680686, 2001 Connor SE, West RJ, Yates DA: The ability of plain radiography to predict intracranial aneurysm occlusion instability during follow-up of endosaccular treatment with Gugliemi detachable coils. Neuroradiology 43:680–686, 2001

    • Search Google Scholar
    • Export Citation
  • 7.

    Derdeyn CP, , Graves VB, , Turski PA, , Masaryk AM, & Strother CM: MR angiography of saccular aneurysms after treatment with Guglielmi detachable coils: preliminary experience. AJNR 18:279286, 1997 Derdeyn CP, Graves VB, Turski PA, Masaryk AM, Strother CM: MR angiography of saccular aneurysms after treatment with Guglielmi detachable coils: preliminary experience. AJNR 18:279–286, 1997

    • Search Google Scholar
    • Export Citation
  • 8.

    Fujimoto JG, , Boppart SA, , Tearney GJ, , Bouma BE, , Pitris C, & Brezinski ME: High resolution in vivo intra-arterial imaging with optical coherence tomography. Heart 82:128133, 1999 Fujimoto JG, Boppart SA, Tearney GJ, Bouma BE, Pitris C, Brezinski ME: High resolution in vivo intra-arterial imaging with optical coherence tomography. Heart 82:128–133, 1999

    • Search Google Scholar
    • Export Citation
  • 9.

    Graves VB, , Ahuja A, , Strother CM, & Rappe AH: Canine model of terminal arterial aneurysm. AJNR 14:801803, 1993 Graves VB, Ahuja A, Strother CM, Rappe AH: Canine model of terminal arterial aneurysm. AJNR 14:801–803, 1993

    • Search Google Scholar
    • Export Citation
  • 10.

    Graves VB, , Partington CR, , Rufenacht DA, , Rappe AH, & Strother CM: Treatment of carotid artery aneurysms with platinum coils: an experimental study in dogs. AJNR 11:249252, 1990 Graves VB, Partington CR, Rufenacht DA, Rappe AH, Strother CM: Treatment of carotid artery aneurysms with platinum coils: an experimental study in dogs. AJNR 11:249–252, 1990

    • Search Google Scholar
    • Export Citation
  • 11.

    Graves VB, , Strother CM, & Rappe AH: Treatment of experimental canine carotid aneurysms with platinum coils. AJNR 14:787793, 1993 Graves VB, Strother CM, Rappe AH: Treatment of experimental canine carotid aneurysms with platinum coils. AJNR 14:787–793, 1993

    • Search Google Scholar
    • Export Citation
  • 12.

    Groden C, , Hagel C, , Delling G, & Zeumer H: Histological findings in ruptured aneurysms treated with GDCs: six examples at varying times after treatment. AJNR 24:579584, 2003 Groden C, Hagel C, Delling G, Zeumer H: Histological findings in ruptured aneurysms treated with GDCs: six examples at varying times after treatment. AJNR 24:579–584, 2003

    • Search Google Scholar
    • Export Citation
  • 13.

    Guglielmi G, , Viñuela F, , Dion J, & Duckwiler G: Electrothrombosis of saccular aneurysms via endovascular approach. Part 2: Preliminary clinical experience. J Neurosurg 75:814, 1991 Guglielmi G, Viñuela F, Dion J, Duckwiler G: Electrothrombosis of saccular aneurysms via endovascular approach. Part 2: Preliminary clinical experience. J Neurosurg 75:8–14, 1991

    • Search Google Scholar
    • Export Citation
  • 14.

    Guglielmi G, , Viñuela F, , Sepetka I, & Macellari V: Electrothrombosis of saccular aneurysms via endovascular approach. Part 1: Electrochemical basis, technique, and experimental results. J Neurosurg 75:17, 1991 Guglielmi G, Viñuela F, Sepetka I, Macellari V: Electrothrombosis of saccular aneurysms via endovascular approach. Part 1: Electrochemical basis, technique, and experimental results. J Neurosurg 75:1–7, 1991

    • Search Google Scholar
    • Export Citation
  • 15.

    Huang D, , Swanson EA, , Lin CP, , Schuman JS, , Stinson WG, & Chang W, et al: Optical coherence tomography. Science 254:11781181, 1991 Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, et al: Optical coherence tomography. Science 254:1178–1181, 1991

    • Search Google Scholar
    • Export Citation
  • 16.

    Inagawa T, & Hirano A: Autopsy study of unruptured incidental intracranial aneurysms. Surg Neurol 34:361365, 1990 Inagawa T, Hirano A: Autopsy study of unruptured incidental intracranial aneurysms. Surg Neurol 34:361–365, 1990

    • Search Google Scholar
    • Export Citation
  • 17.

    International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group: International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet 360:12671274, 2002 International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group: International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet 360:1267–1274, 2002

    • Search Google Scholar
    • Export Citation
  • 18.

    Jang IK, , Bouma BE, , Kang DH, , Park SJ, , Park SW, & Seung KB, et al: Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. J Am Coll Cardiol 39:604609, 2002 Jang IK, Bouma BE, Kang DH, Park SJ, Park SW, Seung KB, et al: Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. J Am Coll Cardiol 39:604–609, 2002

    • Search Google Scholar
    • Export Citation
  • 19.

    Jang IK, , Tearney G, & Bouma B: Visualization of tissue prolapse between coronary stent struts by optical coherence tomography: comparison with intravascular ultrasound. Circulation 104:2754, 2001 Jang IK, Tearney G, Bouma B: Visualization of tissue prolapse between coronary stent struts by optical coherence tomography: comparison with intravascular ultrasound. Circulation 104:2754, 2001

    • Search Google Scholar
    • Export Citation
  • 20.

    Kyle RA, & Shampo MA: Albert Michelson. JAMA 246:880, 1981 Kyle RA, Shampo MA: Albert Michelson. JAMA 246:880, 1981

  • 21.

    Masaryk AM, , Frayne R, , Unal O, , Rappe AH, & Strother CM: Utility of CT angiography and MR angiography for the follow-up of experimental aneurysms treated with stents or Guglielmi detachable coils. AJNR 21:15231531, 2000 Masaryk AM, Frayne R, Unal O, Rappe AH, Strother CM: Utility of CT angiography and MR angiography for the follow-up of experimental aneurysms treated with stents or Guglielmi detachable coils. AJNR 21:1523–1531, 2000

    • Search Google Scholar
    • Export Citation
  • 22.

    McCormick WF, & Acosta-Rua GJ: The size of intracranial saccular aneurysms. An autopsy study. J Neurosurg 33:422427, 1970 McCormick WF, Acosta-Rua GJ: The size of intracranial saccular aneurysms. An autopsy study. J Neurosurg 33:422–427, 1970

    • Search Google Scholar
    • Export Citation
  • 23.

    Mullan S: Experiences with surgical thrombosis of intracranial berry aneurysms and carotid cavernous fistulas. J Neurosurg 41:657670, 1974 Mullan S: Experiences with surgical thrombosis of intracranial berry aneurysms and carotid cavernous fistulas. J Neurosurg 41:657–670, 1974

    • Search Google Scholar
    • Export Citation
  • 24.

    Mullan S: Stereotactic thrombosis of intracranial aneurysms. Confin Neurol 31:94, 1969 Mullan S: Stereotactic thrombosis of intracranial aneurysms. Confin Neurol 31:94, 1969

    • Search Google Scholar
    • Export Citation
  • 25.

    Mullan S, , Raimondi AJ, , Dobben G, , Vailati G, & Hekmatpanah J: Electrically induced thrombosis in intracranial aneurysms. J Neurosurg 22:539547, 1965 Mullan S, Raimondi AJ, Dobben G, Vailati G, Hekmatpanah J: Electrically induced thrombosis in intracranial aneurysms. J Neurosurg 22:539–547, 1965

    • Search Google Scholar
    • Export Citation
  • 26.

    Murayama Y, , Viñuela F, , Tateshima S, , Song JK, , Gonzalez NR, & Wallace MP: Bioabsorbable polymeric material coils for embolization of intracranial aneurysms: a preliminary experimental study. J Neurosurg 94:454463, 2001 Murayama Y, Viñuela F, Tateshima S, Song JK, Gonzalez NR, Wallace MP: Bioabsorbable polymeric material coils for embolization of intracranial aneurysms: a preliminary experimental study. J Neurosurg 94:454–463, 2001

    • Search Google Scholar
    • Export Citation
  • 27.

    Romeike BF, , Niedermayer I, & Feiden W: Histopathologische Befunde in Hirnbasisarterienaneurysmen nach Embolisation mit Guglielmi detachable platinum coils (GDC). Zwei Fallberichte. Radiologe 39:900903, 1999 Romeike BF, Niedermayer I, Feiden W: Histopathologische Befunde in Hirnbasisarterienaneurysmen nach Embolisation mit Guglielmi detachable platinum coils (GDC). Zwei Fallberichte. Radiologe 39:900–903, 1999

    • Search Google Scholar
    • Export Citation
  • 28.

    Serbinenko FA: Balloon catheterization and occlusion of major cerebral vessels. J Neurosurg 41:125145, 1974 Serbinenko FA: Balloon catheterization and occlusion of major cerebral vessels. J Neurosurg 41:125–145, 1974

    • Search Google Scholar
    • Export Citation
  • 29.

    Sorteberg A, , Sorteberg W, , Rappe A, & Strother CM: Effect of Guglielmi detachable coils on intraaneurysmal flow: experimental study in canines. AJNR 23:288294, 2002 Sorteberg A, Sorteberg W, Rappe A, Strother CM: Effect of Guglielmi detachable coils on intraaneurysmal flow: experimental study in canines. AJNR 23:288–294, 2002

    • Search Google Scholar
    • Export Citation
  • 30.

    Sorteberg A, , Sorteberg W, , Turk AS, , Rappe A, , Nakstad PH, & Strother CM: Effect of Guglielmi detachable coil placement on intraaneurysmal pressure: experimental study in canines. AJNR 22:17501756, 2001 Sorteberg A, Sorteberg W, Turk AS, Rappe A, Nakstad PH, Strother CM: Effect of Guglielmi detachable coil placement on intraaneurysmal pressure: experimental study in canines. AJNR 22:1750–1756, 2001

    • Search Google Scholar
    • Export Citation
  • 31.

    Strother CM: Understanding the natural history of saccular aneurysms. AJNR 19:11831184, 1998 Strother CM: Understanding the natural history of saccular aneurysms. AJNR 19:1183–1184, 1998

    • Search Google Scholar
    • Export Citation
  • 32.

    Strother CM, , Graves VB, & Rappe A: Aneurysm hemodynamics: an experimental study. AJNR 13:10891095, 1992 Strother CM, Graves VB, Rappe A: Aneurysm hemodynamics: an experimental study. AJNR 13:1089–1095, 1992

    • Search Google Scholar
    • Export Citation
  • 33.

    Tearney GJ, , Brezinski ME, , Boppart SA, , Bouma BE, , Weissman N, & Southern JF, et al: Images in cardiovascular medicine. Catheter-based optical imaging of a human coronary artery. Circulation 94:3013, 1996 Tearney GJ, Brezinski ME, Boppart SA, Bouma BE, Weissman N, Southern JF, et al: Images in cardiovascular medicine. Catheter-based optical imaging of a human coronary artery. Circulation 94:3013, 1996

    • Search Google Scholar
    • Export Citation
  • 34.

    Tearney G, , Brezinski ME, , Southern JF, , Bouma BE, , Hee MR, & Fujimoto JG: Determination of the refractive index of highly scattering human tissue by optical coherence tomography. Optics Letters 20:2258, 1995 Tearney G, Brezinski ME, Southern JF, Bouma BE, Hee MR, Fujimoto JG: Determination of the refractive index of highly scattering human tissue by optical coherence tomography. Optics Letters 20:2258, 1995

    • Search Google Scholar
    • Export Citation
  • 35.

    Turk AS, , Strother CM, , Crouthamel DI, & Zagzebski JA: Definition of the ostium (neck) of an aneurysm revealed by intravascular sonography: an experimental study in canines. AJNR 20:13011308, 1999 Turk AS, Strother CM, Crouthamel DI, Zagzebski JA: Definition of the ostium (neck) of an aneurysm revealed by intravascular sonography: an experimental study in canines. AJNR 20:1301–1308, 1999

    • Search Google Scholar
    • Export Citation
  • 36.

    Vallee B: Le syndrome d'hemorragie meningee et l'etiologie anevrismale. De Morgagni a Moniz, Dott et Dandy: un apercu historique. Neurochirurgie 44:105110, 1998 Vallee B: Le syndrome d'hemorragie meningee et l'etiologie anevrismale. De Morgagni a Moniz, Dott et Dandy: un apercu historique. Neurochirurgie 44:105–110, 1998

    • Search Google Scholar
    • Export Citation
  • 37.

    Werner SC, , Blakemore AH, & King BG: Aneurysm of the internal carotid artery within the skull. Wiring and electrothermic coagulation. JAMA 116:578582, 1941 Werner SC, Blakemore AH, King BG: Aneurysm of the internal carotid artery within the skull. Wiring and electrothermic coagulation. JAMA 116:578–582, 1941

    • Search Google Scholar
    • Export Citation
  • 38.

    Wiebers DO, & Whisnant JP: Rupture of an intracranial aneurysm. Surg Neurol 33:157158, 1990 Wiebers DO, Whisnant JP: Rupture of an intracranial aneurysm. Surg Neurol 33:157–158, 1990

    • Search Google Scholar
    • Export Citation
  • 39.

    Yabushita H, , Bouma BE, , Houser SL, , Aretz HT, , Jang IK, & Schlendorf KH, et al: Characterization of human atherosclerosis by optical coherence tomography. Circulation 106:16401645, 2002 Yabushita H, Bouma BE, Houser SL, Aretz HT, Jang IK, Schlendorf KH, et al: Characterization of human atherosclerosis by optical coherence tomography. Circulation 106:1640–1645, 2002

    • Search Google Scholar
    • Export Citation

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