Intramedullary Ewing sarcoma of the spinal cord: consequences of molecular diagnostics

Case report

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  • 1 Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, and Laboratory of Pathology, Pediatric Oncology and Radiation Oncology Branches, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
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✓ Molecular biological techniques have begun to transform modern medicine. These techniques have shown promise in the pathological diagnosis of difficult or uncommon tumors. Accurate molecular diagnosis of the small round-cell tumors, for example, is especially important because divergent therapies may be required to eradicate such disparate lesions as neuroblastoma, lymphoma, rhabdomyosarcoma, central primitive neuroectodermal tumors/medulloblastoma, or Ewing sarcoma (ES). The authors present an unusual case of a primary, extraosseous ES arising from the intramedullary spinal cord, in which molecular studies were required for specific diagnosis and therapeutic guidance.

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