Letter to the Editor: Syringomyelia

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To The Editor: Syringomyelia is a disorder characterized by fluid accumulation in the spinal cord. Despite almost a century of research and numerous theories, its pathophysiology remains elusive. In the Journal of Neurosurgery: Spine, Hemley et al.3 published an article (Hemley SJ, Bilston LE, Cheng S, et al: Aquaporin-4 expression and blood–spinal cord barrier permeability in canalicular syringomyelia. Laboratory investigation. J Neurosurg Spine 17:602–612, December 2012). Blood–spinal cord barrier (BSCB) disruption was demonstrated by means of intravenously injected horseradish peroxidase leakage in the perivascular space. Aquaporin-4 (AQP4) and

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Please include this information when citing this paper: published online March 29, 2013; DOI: 10.3171/2012.12.SPINE121095.

© AANS, except where prohibited by US copyright law.

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References

1

Aghayev KBal ERahimli TMut MBalcı SVrionis F: Expression of water channel aquaporin-4 during experimental syringomyelia. Laboratory investigation. J Neurosurg Spine 15:4284322011

2

Heiss JDSnyder KPeterson MMPatronas NJButman JASmith RK: Pathophysiology of primary spinal syringomyelia. Clinical article. J Neurosurg Spine 17:3673802012

3

Hemley SJBilston LECheng SStoodley MA: Aquaporin-4 expression and blood–spinal cord barrier permeability in canalicular syringomyelia. Laboratory investigation. J Neurosurg Spine 17:6026122012

4

Milhorat THNobandegani FMiller JIRao C: Noncommunicating syringomyelia following occlusion of central canal in rats. Experimental model and histological findings. J Neurosurg 78:2742791993

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