En bloc spondylectomy for treatment of tumor-induced osteomalacia

Case report

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  • 1 Departments of Neurosurgery and
  • 2 Pathology and Orthopaedics, Johns Hopkins University, Baltimore; and
  • 3 Department of Medicine, National Institutes of Health, Bethesda, Maryland
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En bloc spondylectomy represents a radical resection of a spinal segment most often reserved for patients presenting with a primary extradural spine tumor or a solitary metastasis in the setting of an indolent, well-controlled systemic malignancy. The authors report a case in which en bloc spondylectomy was conducted to control a metabolically active spine tumor. A 56-year-old woman, who suffered from severe tumor-induced osteomalacia, was found to have a fibroblast growth factor-23–secreting phosphaturic mesenchymal tumor in the T-8 vertebral body. En bloc resection was conducted, leading to resolution of her tumor-induced osteomalacia. This case suggests that radical spondylectomy may be beneficial in the management of metabolically or endocrinologically active tumors of the spine.

Abbreviations used in this paper: BMP = bone morphogenic protein; FGF-23 = fibroblast growth factor-23; PMT = phosphaturic mesenchymal tumor; PTH = parathyroid hormone.

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Contributor Notes

Address correspondence to: Daniel M. Sciubba, M.D., 600 North Wolfe Street, Meyer 8-161, Baltimore, Maryland 21287. email:dsciubb1@jhmi.edu.
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