Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine

Case report

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  • 1 Neurosurgery and
  • 2 Pathology Departments, University of Milano-Bicocca, Monza, Italy
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Phosphaturic mesenchymal tumors that cause the paraneoplastic syndrome known as oncogenic osteomalacia are rare. The authors report on the case of a 57-year-old man with a history of osteomalacia and in whom was diagnosed a thoracic spine tumor at the T-4 level. Complete tumor resection was accomplished. The histological diagnosis was phosphaturic mesenchymal tumor (mixed connective tissue variant). After lesion removal, the paraneoplastic syndrome resolved. At the 24-month follow-up, no recurrence of the disease was observed. The clinical presentation, surgical technique, and follow-up in this case were reviewed in detail.

Abbreviations used in this paper: FGF-23 = fibroblast growth factor–23; OO = oncogenic osteomalacia; PMTMCT = phosphaturic mesenchymal tumor, mixed connective tissue variant.

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Contributor Notes

Address correspondence to: Elena Pirola, M.D., 106 Donizetti, S. Gerardo Hospital, 20052 Monza, Italy. email: oxosintesi@libero.it.
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