Search Results

You are looking at 1 - 10 of 1,569 items for :

  • tumor subtype x
  • Refine by Access: all x
Clear All
Restricted access

Robert G. Whitmore, Jaroslaw Krejza, Gurpreet S. Kapoor, Jason Huse, John H. Woo, Stephanie Bloom, Joanna Lopinto, Ronald L. Wolf, Kevin Judy, Myrna R. Rosenfeld, Jaclyn A. Biegel, Elias R. Melhem, and Donald M. O'rourke

. This novel finding not only emphasizes important biological differences between tumor cytogenetic subtypes, but also allows the development of models based on perfusion MR imaging measurements that can predict the histopathological grade or cytogenetic type of oligodendroglial neoplasms. In this study we demonstrate the use of advanced imaging modalities such as perfusion weighted MR imaging in noninvasive determination of molecular subtypes of human gliomas. The MR imaging surrogates may be used during patient treatment to more accurately predict response to

Restricted access

Avital Perry, Christopher S. Graffeo, Lucas P. Carlstrom, Aditya Raghunathan, Colin L. W. Driscoll, Brian A. Neff, Matthew L. Carlson, Ian F. Parney, Michael J. Link, and Jamie J. Van Gompel

mechanism for immunophenotype of VS populations and the association with PD-L1 and macrophage subtype in tumor recurrence and aggressiveness. Copyright Mayo Clinic. Published with permission. Figure is available in color online only. Of particular interest, Bi et al. recently reported, in a series of 90 VSs, significant increases in the expression of negative immune system regulators, such as PD-L1 and TIM3, as well as increased expression of T-cell exhaustion markers, such as LAG3. 7 Although their data were not reported with correlated clinical outcomes, these

Free access

Ichiro Nakano

, 34 , 37 Among these 3 subtypes, approximately half of HGGs with the PN signature are associated with CpG island methylator phenotype (CIMP + ), mutations in the metabolic enzyme IDH1, and the onco-metabolite 2-hydroxyglutarate. 24 Clinically, this group of HGGs, which tend to slowly progress from low-grade glioma to eventual GBM, was previously classified as secondary GBM. From the therapeutic standpoint, treatment plans for this subclass should be designed separately, given the significantly better prognosis compared with the rest of the HGG tumor subtypes. The

Restricted access

Hidehiro Takei, Yummy Nguyen, Vidya Mehta, Murali Chintagumpala, Robert C. Dauser, and Adekunle M. Adesina

A s a group, brain tumors are the second most common malignancies among children, leukemias being the most common. Medulloblastomas are the most common malignant brain tumors of childhood and account for ~ 15% of all pediatric primary CNS tumors. They have a characteristic propensity for early dissemination through the CSF and for forming microscopic or bulky metastases, and are thus associated with significant morbidity and mortality. Histologically, MBs are mainly subtyped as classic, nodular, large cell, or anaplastic according to the current WHO

Restricted access

Primary intracranial germ-cell tumors

A clinicopathological study of 14 cases

Ali Shokry, Robert C. Janzer, Arthur R. Von Hochstetter, Mahmut Gazi Yaşargil, and Christoph Hedinger

T he World Health Organization classification of intracranial germ-cell tumors 32 is based on the much more detailed classification of testicular tumors. 14 However, it has not been established if the subtypes described for the testicular location are found with the same relative incidence intracranially and if they show the same biological behavior. These questions can only be answered when a direct surgical approach is used. There is a controversy about management of these tumors between proponents of primary surgical excision 10, 15, 25 and supporters of

Restricted access

Zhiyu Zhang, Yingqi Hua, Guodong Li, Wei Sun, Shuo Hu, Jian Li, and Zhengdong Cai

most anterior protrusion point of the sacral tumor extending into the pelvic cavity and the front edge of the sacrum ( Fig. 1 ). The subtypes are determined according to the D-value: the D-value of Subtype a is less than 5 cm, and the D-value of Subtype b is greater than or equal to 5 cm. Thus, tumors are divided into Types I a, I b, II a, and II b. Type I higher sacral tumors are further divided according to the anatomical region, which is separated into 3 zones in the transverse section: Zone 1 is the presacral area, Zone 2 is the sacroiliac joint area, and Zone 3

Restricted access

Ranjith Babu, Jacob H. Bagley, Jong G. Park, Allan H. Friedman, and Cory Adamson

, 12 , 13 , 19 , 22 , 26 , 28 Recently, some of the different histological subtypes recognized in LGAs have been suggested to impact patient outcome. Fibrillary astrocytomas are the most common variant and are characterized by the presence of fibrillary astrocytes among a loose, microcystic tumor matrix. The gemistocytic subtype is characterized by the presence of gemistocytes with eosinophilic cytoplasm, plump cell processes, and cytoplasmic accumulation of GFAP. These tumors have been thought to have significantly lower survival compared with those with little or

Restricted access

Shozo Yamada, Kalman Kovacs, Eva Horvath, and Tadashi Aiba

ultrastructural features of unknown derivation or cells of one of the established adenohypophyseal types. 3, 5, 6, 12 Besides null-cell adenomas and oncocytomas, these tumors include silent subtype 3 adenomas of obscure origin as well as silent gonadotroph, corticotroph, thyrotroph, and somatotroph adenomas. 2, 3, 5, 6, 12, 16 In this paper, we present the morphology of 69 clinically nonsecreting pituitary adenomas removed surgically from patients under 40 years of age. For comparison, 253 randomly collected morphologically identified null-cell adenomas and oncocytomas

Restricted access

Naoki Shinojima, Hideo Nakamura, Masayoshi Tasaki, Kouki Kameno, Shigeo Anai, Ken-ichi Iyama, Yukio Ando, Hiroshi Seto, and Jun-ichi Kuratsu

synaptophysin ( Fig. 2B ) and negative for GFAP (data not shown). The MIB-1 labeling index, representing the percentage of positively stained tumor nuclei, was more than 20.0%. Interestingly, the tumor mainly stained for DKK1 ( Fig. 2C and D ) and NPR3 ( Fig. 2E and F ), which are representative of the WNT subtype and Group 3 subtype, respectively. Even more interestingly, individual regions of the tumor stained only for DKK1 or NPR3, but not both— that is, DKK1 and NPR3 expression were mutually exclusive ( Fig. 2C – F ). Few tumor cells were immunoreactive for SFRP1

Restricted access

Michael D. Partington, Bernd W. Scheithauer, and David G. Piepgras

subtype. The second was a recent report by Louis, et al. , 13 in which a secretory meningioma was found to be the source of circulating CEA. In the latter case, serum CEA levels returned to normal following tumor resection. The last and most recent case was that of Tsunoda, et al. , 21 in which serum CEA elevation and diminution accompanied a secretory meningioma and its resection, respectively. Our report documents the first case of serum CEA elevation associated with an atypical meningioma without secretory features, in which serial measurements of CEA reflected