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Epidemiology of craniosynostosis in Norway

Elin Tønne, Bernt J. Due-Tønnessen, Ulrikke Wiig, Barbro F. Stadheim, Torstein R. Meling, Eirik Helseth, and Ketil R. Heimdal

, 11 , 15 , 16 of all cases. The sagittal suture is the most commonly affected suture, the proportion varying between 41% and 68%. 10 , 17–19 The male/female ratio ranges from 1.8:1 to 4.7:1, 13 , 15 , 20–22 and the proportion of familial craniosynostosis is reported to be between 5.6% and 14.7%. 14 , 22 , 23 The epidemiology of craniosynostosis in the literature varies significantly between countries, regions, and medical centers. To our knowledge, the epidemiology of craniosynostosis has not previously been reported from any Scandinavian country. The objective

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The molecular epidemiology of gliomas in adults

Margaret Wrensch, James L. Fisher, Judith A. Schwartzbaum, Melissa Bondy, Mitchel Berger, and Kenneth D. Aldape

In this paper the authors highlight recent findings from molecular epidemiology studies of glioma origin and prognosis and suggest promising paths for future research. The reasons for variation in glioma incidence according to time period of diagnosis, sex, age, ancestry and ethnicity, and geography are poorly understood, as are factors that affect prognosis. High-dose therapeutic ionizing irradiation and rare mutations in highly penetrant genes associated with certain rare syndromes—the only two established causes of glioma—can be called upon to explain few cases. Both familial aggregation of gliomas and the inverse association of allergies and immune-related conditions with gliomas have been shown consistently, but the explanations for these associations are inadequately developed or unknown. Several bio-markers do predict prognosis, but only evaluation of loss of 1p and 19q in oligodendroglial tumors are incorporated in clinical practice. Ongoing research focuses on classifying homogeneous groups of tumors on the basis of molecular markers and identifying inherited polymorphisms that may influence survival or risk. Because most cases of glioma have yet to furnish either an environmental or a genetic explanation, the greatest potential for discovery may lie in genomic studies in conjunction with continued evaluation of environmental and developmental factors. Large sample sizes and multidisciplinary teams with expertise in neuropathology, genetics, epidemiology, functional genomics, bioinformatics, biostatistics, immunology, and neurooncology are required for these studies to permit exploration of potentially relevant pathways and modifying effects of other genes or exposures, and to avoid false-positive findings. Improving survival rates for patients harboring astrocytic tumors will probably require many randomized clinical trials of novel treatment strategies.

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The role for adjuvant radiotherapy in the treatment of hemangiopericytoma: a Surveillance, Epidemiology, and End Results analysis

Clinical article

Adam M. Sonabend, Brad E. Zacharia, Hannah Goldstein, Samuel S. Bruce, Dawn Hershman, Alfred I. Neugut, and Jeffrey N. Bruce

are based on single-center experiences. We used the Surveillance, Epidemiology and End Results (SEER) database of the National Cancer Institute to analyze the incidence, treatment, and survival of patients with CNS hemangiopericytomas. Methods Patient Identification We identified patients with a diagnosis of hemangiopericytoma registered in the SEER Program of the National Cancer Institute. The SEER database is a population-based tumor registry containing data covering approximately 26% of the US population. Information concerning primary tumor type

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Epidemiology of adult-onset hydrocephalus: institutional experience with 2001 patients

Shyamal C. Bir, Devi Prasad Patra, Tanmoy K. Maiti, Hai Sun, Bharat Guthikonda, Christina Notarianni, and Anil Nanda

-3680(18)30032-9 8 Dubrow R , Darefsky AS : Demographic variation in incidence of adult glioma by subtype, United States, 1992–2007 . BMC Cancer 11 : 325 , 2011 10.1186/1471-2407-11-325 9 Elder JB , Chen TC : Surgical interventions for primary central nervous system lymphoma . Neurosurg Focus 21 : 5 E13 , 2006 10 Fisher JL , Schwartzbaum JA , Wrensch M , Wiemels JL : Epidemiology of brain tumors . Neurol Clin 25 : 867 – 890 , 2007 10.1016/j.ncl.2007.07.002 11 Ghods AJ , Munoz L , Byrne R : Surgical treatment of cerebellar

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Treatment and survival of patients with nonmalignant intracranial meningioma: results from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute

Clinical article

Kevin S. Cahill and Elizabeth B. Claus

-control study assessing morbidity and mortality . Acta Neurochir (Wien) 140 : 1013 – 1017 , 1998 3 Bondy M , Ligon BL : Epidemiology and etiology of intracranial meningiomas: a review . J Neurooncol 29 : 197 – 205 , 1996 4 Central Brain Tumor Registry of the United States (CBTRUS) : CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2004–2007 . ( ). [Accessed March 29, 2011] 5 Caroli M , Locatelli M , Prada F , Beretta F

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The descriptive epidemiology of craniopharyngioma

Greta R. Bunin, Tanya S. Surawicz, Philip A. Witman, Susan Preston-Martin, Faith Davis, and Janet M. Bruner

T he demographic patterns of craniopharyngioma are not well described because the tumor is rare. In addition, most cancer registries collect data only on malignant conditions and, therefore, they are not useful in the study of craniopharyngioma, considered to be of borderline histological malignancy. The objective of this report is to describe the epidemiology of craniopharyngioma. Incidence rates by gender, age, and race were calculated from three population-based cancer registries that include data on brain tumors of benign and borderline malignancy

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Epidemiology of traumatic spinal fractures: experience from medical university–affiliated hospitals in Chongqing, China, 2001–2010

Clinical article

Hongwei Wang, Yuan Zhang, Qiang Xiang, Xuke Wang, Changqing Li, Hongyan Xiong, and Yue Zhou

.1097/00005373-199603000-00004 4 Hu R , Mustard CA , Burns C : Epidemiology of incident spinal fracture in a complete population . Spine (Phila Pa 1976) 21 : 492 – 499 , 1996 10.1097/00007632-199602150-00016 5 Jansson KA , Blomqvist P , Svedmark P , Granath F , Buskens E , Larsson M , : Thoracolumbar vertebral fractures in Sweden: an analysis of 13,496 patients admitted to hospital . Eur J Epidemiol 25 : 431 – 437 , 2010 10.1007/s10654-010-9461-5 6 Lane PL , McClafferty KJ , Nowak ES : Pedestrians in real world collisions . J Trauma 36 : 231

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Scoliosis in myelomeningocele: epidemiology, management, and functional outcome

Nishit Mummareddy, Michael C. Dewan, Michael R. Mercier, Robert P. Naftel, John C. Wellons III, and Christopher M. Bonfield

-to-date systematic review examining the most important clinical questions surrounding MMC patients suffering from scoliosis. We have sought to address the epidemiology and management outcomes in these patients in a concise and straightforward report. From our literature search and analysis, several significant patterns were identified and we elaborate on them below. More female MMC patients had scoliosis than male MMC patients. 1 , 43 Whether this increased female predilection is due to an underlying pathophysiological process or whether it is simply due to higher rates of

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Editorial: Epidemiology

John H. Sampson, James E. Herndon II, Allan H. Friedman, and Amy P. Abernethy

In the following article, Cahill and Claus, 1 neurosurgeons and experienced epidemiologists, mine the Surveillance, Epidemiology, and End Results (SEER) database, a population-based tumor registry sponsored by the National Cancer Institute (NCI), to identify predictors for undergoing resection and to investigate prognoses among patients with nonmalignant intracranial meningiomas. In this database the authors had access to information on an extraordinary 12,284 patients. Using this population-based database, they conclusively demonstrated that patients

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Pediatric spinal injury in the US: epidemiology and disparities

Joseph H. Piatt Jr.

black patients and among patients with Medicaid or no insurance. Patients in these categories had startling rates of firearm-related injury, 23.9% and 10.3%, respectively. Black patients also had the highest rates of SCI. Like other traumatic conditions, the epidemiology of pediatric spinal injury in the US cannot be understood apart from considerations of race and economic status. Having demonstrated that patients of different racial and economic categories sustain qualitatively and quantitatively different injuries, a second goal of this investigation was to