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Skull base amyloidoma

Case report

Faruk Ünal, Kemal Hepgül, Çiçek Bayindir, Turgay Bilge, Murat İmer, and İnan Turantan

A myloidosis , the extracellular deposition of abnormal protein material, is a well-known entity exhibiting a variety of clinical manifestations. Amyloid may be deposited at local sites or systemically and can affect any tissue; 22 however, a mass lesion of amyloid involving the central nervous system (CNS) is a rare finding. In this report, we present the case of a patient with a large amyloidoma at the skull base causing CNS compression, and we review the literature. Case Report This 64-year-old woman was admitted to our institution with a 12-month

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Skull base tumor model

Laboratory investigation

Cristian Gragnaniello, Remi Nader, Tristan van Doormaal, Mahmoud Kamel, Eduard H. J. Voormolen, Giovanni Lasio, Emad Aboud, Luca Regli, Cornelius A. F. Tulleken, and Ossama Al-Mefty

pathological anatomy becomes more essential in the face of complex deep-seated skull base lesions. This is due to the relative infrequency of these tumors and the complexity of the regional anatomy. In an attempt to advance surgical training, we have elaborated a tumor model that has very similar property characteristics of certain common brain tumors, in terms of dissection from neural and vascular structures and consistency. We describe the technique to prepare the tumor, as well as the proposed model. Methods This study was performed at the Dianne and Mahmut Gazi

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Clemens M. Schirmer and Carl B. Heilman

features identical with meningeal HPCs ultimately led to the latter's more accurate classification as “mesenchymal nonmeningothelial tumors,” which can arise from multiple organ systems. 15 , 17 , 28 Moreover, the long-term biological and/or clinical behavior of an HPC differs from that of a meningioma, with its local recurrence rates as high as 91% and a 15-year risk of distant metastasis approaching 70% after surgery alone. 8 We describe 3 patients with HPCs of the skull base. Neurosurgeons have treated these lesions as meningioma variants for a long time, and

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Brown tumors of the skull base

Case report and review of the literature

Mubarak Al-Gahtany, Michael Cusimano, William Singer, Juan Bilbao, Kalman Kovacs, and Thomas Marotta

S everal types of primary tumors are found in the skull base; in addition, secondary tumors, originating from hematogenous sources or direct invasion from adjacent structures, are also known to occur. 25 In rare cases, the skull base is involved through reparative processes such as giant-cell granuloma and osteitis fibrosa cystica (brown tumor), which lead to the formation of lesions that can simulate tumors on neuroimaging as well as clinically, and even pathologically. We present the case of a woman who harbored a brown tumor of the ethmoidofrontal skull

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Ossama Al-Mefty and Vinod K. Anand

A variety of tumors, such as angiofibromas, schwannomas, and carcinomas, occupy the infratemporal fossa and may involve the adjacent area: the skull base, intracranial cavity, cavernous sinus, orbit, and sphenopalatine fossa. Several approaches to the skull base have been developed to reach lesions in this location. Some of these approaches are hindered by the need for an extensive skull-base exposure and reconstruction, 4, 8, 9, 13, 15 or by a need to transgress the contaminated flora of the maxillary sinus. 2, 10 Fisch, et al. , 7 have developed and

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Douglas Kondziolka, John C. Flickinger, and L. Dade Lunsford

M ost patients who undergo SRS at the skull base have a benign tumor such as a schwannoma, meningioma, or pituitary adenoma. Such patients are expected to live for an extended period. Thus, practitioners must strive for long-term tumor control after radiosurgery, and the morbidity profile must be low. Effective radiosurgery is based on the principles of specificity and selectivity. 11 Precision and conformal dose planning allow specific target irradiation with a steep falloff into other surrounding structures. Selectivity refers to the biological

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Ossama Al-Mefty and Luis A. B. Borba

C hordomas are rare, aggressive, and locally destructive tumors that presumably originate from remnants of the primitive notochord. 27, 34, 56 Although these remnants may persist anywhere along the axial skeleton, the sacrococcygeal region and the clivus are the sites of predilection. 39 Surgical treatment has a definitive role in the management of skull base chordomas. Longer survival rates have been associated with more extensive tumor removal. 6, 11, 25, 51, 55 Aggressive surgical treatment, however, has been associated with higher morbidity and

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Naoya Hashimoto, Carter S. Rabo, Yoshiko Okita, Manabu Kinoshita, Naoki Kagawa, Yasunori Fujimoto, Eiichi Morii, Haruhiko Kishima, Motohiko Maruno, Amami Kato, and Toshiki Yoshimine

time, and that they do not always grow exponentially but rather exhibit complex patterns of growth. 6 In addition, the presentation of calcification on CT or MR imaging has a negative impact on its growth. We further surveyed other factors predictive of IDM growth, and we identified tumor location, that is, non–skull base versus skull base, as a potentially useful clinicoradiological predictor of the growth behavior of IDMs. Here, we report our results and discuss biological evidence to support these findings through expansion of the theory involving symptomatic

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Alireza Mansouri, George Klironomos, Shervin Taslimi, Alex Kilian, Fred Gentili, Osaama H. Khan, Kenneth Aldape, and Gelareh Zadeh

structures, typically in the skull base. Also, it has been suggested that even upon achieving an apparent gross-total resection (GTR), microscopic remnants may remain adherent to neurovascular structures, resulting in recurrence. 2 , 6 , 21 Studies assessing the long-term outcomes of surgically resected meningiomas suggest that the recurrence rate is a clinically relevant concern, despite the benign nature of the majority of meningiomas, particularly for subtotally resected lesions, and follow-up beyond 10–20 years is required. 19 , 30 The majority of surgical series

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Fadi Hanbali, Peyman Tabrizi, Frederick F. Lang, and Franco DeMonte

A lthough tumors of the skull base are rare in children and adolescents, they represent a considerable management problem for oncologists. Of the tumors that do occur in this age group, many are chemosensitive and these cases are consequently not referred to neurosurgeons. Conversely, resection is an important component of the management of many pediatric neoplasms, especially those that are benign or, although not frankly malignant, are locally invasive. 8 Despite the critical role of surgery in these tumors, the majority of investigators have focused on the