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Gopal K. Dash, Chaturbhuj Rathore, Malcolm K. Jeyaraj, Pandurang Wattamwar, Sankara P. Sarma and Kurupath Radhakrishnan

cortical dysplasia (FCD) in 19 (27%) patients. 9 Similar to patients with other types of structural lesions, patients with drug-resistant epilepsy and focal gliosis on MRI may benefit from well-planned epilepsy surgery. However, there is a relative dearth of information about the potential problems faced during the presurgical evaluation of patients with focal gliosis, their postsurgical seizure outcome, and the predictors of postoperative outcome. As focal gliosis is a commonly encountered substrate for drug-resistant epilepsy at our center, we planned this study with

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Taner Tanriverdi, Andre Olivier, Nicole Poulin, Frederick Andermann and François Dubeau

especially in terms of seizure outcome have been found to be comparable to each other. 31 , 50 However, advancing imaging techniques and an evolving body of knowledge related to pathogenetic bases of HS have raised a debate about the relative merit of SelAH versus CorAH for the treatment of MTLE/HS. One key question is whether the epileptogenic zone involves both the lateral temporal cortex and mesial structures or if the latter alone is sufficient to generate seizure in MTLE. It is also still unclear whether more limited surgical approaches produce equal success rates

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Micol Babini, Marco Giulioni, Ercole Galassi, Gianluca Marucci, Matteo Martinoni, Guido Rubboli, Lilia Volpi, Mino Zucchelli, Francesca Nicolini, Anna Federica Marliani, Roberto Michelucci and Fabio Calbucci

seizure outcome in tumor-related epilepsy lump together a wide variety of tumors (such as pilocytic astrocytomas, oligodendrogliomas, diffuse astrocytomas, gangliogliomas, and DNETs) without distinguishing outcomes between the adult and pediatric populations. Only a few studies are focused on the seizure outcome of LGTs in the pediatric age group alone. 34 , 45 , 51 , 55 , 57 , 69 The purpose of this work is to report our experience with the surgical treatment of focal epilepsy associated with LGTs in children, focusing on the long-term seizure outcome in relation to

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Taner Tanriverdi, André Olivier, Nicole Poulin, Frederick Andermann and François Dubeau

aim of the present retrospective clinical report is to present the long-term seizure outcome following CC performed at the MNI. We report on a series of 95 patients with a variety of seizure patterns who underwent CC and have now been followed up for 5–25 years (mean 17.2 years). Methods Study Population Between 1981 and 2001, a total of 134 patients underwent CC at the MNI; the records of all patients were retrospectively reviewed. Selection criteria for CC as described previously for this procedure 1 , 3 were as follows: 1) the presence of medically

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Marco Giulioni, Guido Rubboli, Gianluca Marucci, Matteo Martinoni, Lilia Volpi, Roberto Michelucci, Anna Federica Marliani, Francesca Bisulli, Paolo Tinuper, Laura Castana, Ivana Sartori and Fabio Calbucci

migration abnormalities. 2 , 19 , 29 , 42 , 56 The optimal surgical treatment of epileptogenic glioneuronal tumors has not been fully established. Postsurgical seizure outcome of patients with glioneuronal tumors has been evaluated in nonhomogeneous groups, grouping glioneuronal tumors with other tumor types, considering glioneuronal tumors in different brain regions, or grouping together different surgical strategies. 2 , 10 , 11 , 29–31 , 34 , 42 Some investigators consider resection of the tumor alone sufficient for good seizure control, 10 , 11 , 24 , 28 , 30 , 40

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Marco Giulioni, Gianluca Marucci, Matteo Martinoni, Lilia Volpi, Patrizia Riguzzi, Anna Federica Marliani, Francesca Bisulli, Paolo Tinuper, Carlo Alberto Tassinari, Roberto Michelucci and Guido Rubboli

D rug-resistant MTLE is the most common type of epilepsy requiring surgical treatment, with a favorable seizure outcome being achieved in about 60%–75% of patients. 50 , 51 , 64 , 82 , 89 Clinically, MTLE is often regarded as a relatively homogeneous syndromic entity, with seizures characterized by typical ictal semiology 32 , 96 and EEG findings. 29 , 96 However, a variety of MTLE subtypes have been described according to the underlying etiology, with different surgical prognoses. 47 , 89 , 92 Recent neuropathological classifications of epileptogenic

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Chima O. Oluigbo, Jichuan Wang, Matthew T. Whitehead, Suresh Magge, John S. Myseros, Amanda Yaun, Dewi Depositario-Cabacar, William D. Gaillard and Robert Keating

F ocal cortical dysplasias (FCDs) are malformations of cortical development that result from abnormal neuronal migration and differentiation. They have been identified as one of the most common causes of intractable epilepsy leading to surgery in children. However, the predictors of freedom from seizures after surgical management for FCD are still being elucidated. Several clinical research groups have studied the impact of different radiological or clinicopathological factors on seizure outcome after extirpative surgery for FCD. 4–9 , 11–15 , 23 , 24 , 26

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H. Gregor Wieser, Marcos Ortega, Alon Friedman and Yasuhiro Yonekawa

physicians to refer their patients to surgery may be the small number of patients in many outcome studies, limited data regarding the complications of surgery, inconsistent seizure outcome classifications, and the short postoperative follow-up periods covered in most studies. Although short-term surgical results obtained worldwide are encouraging, the long-term outcomes of these patients are less clear, particularly regarding the individual recurrence rate and the “running-down phenomenon” of auras and seizures over time. 25 Because both of these affect the selection of

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Ching-Jen Chen, Srinivas Chivukula, Dale Ding, Robert M. Starke, Cheng-Chia Lee, Chun-Po Yen, Zhiyuan Xu and Jason P. Sheehan

associated with AVMs are not well defined, with relatively few studies investigating seizure outcomes following SRS. 5 , 69 To evaluate the efficacy of SRS for the treatment of AVM-related seizures and identify factors associated with improved post-SRS seizure control, we performed a systematic review of the available literature regarding AVM seizure outcomes following SRS. Methods Inclusion Criteria Inclusion criteria for the studies were defined in an attempt to ensure a balance between a relatively homogeneous and the largest possible patient population. The

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Chow Huat Chan, Richard G. Bittar, Gavin A. Davis, Renate M. Kalnins and Gavin C. A. Fabinyi

F irst described in 1988 by Daumas-Duport, et al., 11 DNETs are benign intracortical tumors with a mal-developmental origin, often occurring in association with early-onset complex partial epilepsy that progresses to medically intractable epilepsy. Surgical lesion removal, complete or incomplete, is reported to result in favorable seizure outcome with no evidence of radiological or clinical recurrence. Authors of many published studies have analyzed DNETs together with other epileptogenic lesions, such as hippocampal sclerosis, low-grade gliomas, or FCD