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Athanasios Smokovitis and Tage Astrup

produce complete lysis of the fibrin layer in 120 minutes in the absence of a tissue section. Unlysed fibrin remaining after 120 minutes or longer of incubation is indicative of the presence of inhibitors of plasmin at the corresponding areas of the tissue section. In total, 100 to 120 sections from each specimen were examined by the “sandwich” slide technique concurrent with the evaluation of plasminogen activator activity by the regular fibrin slide technique in order to secure identical experimental conditions and a more accurate comparison. In some control

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Raymond Sawaya, Thaddeus Mandybur, Illona Ormsby and John M. Tew Jr.

26. Tovi D , Pandolfi M , Åstedt B : Local haemostasis in brain tumours. Experientia 31 : 977 – 978 , 1975 Tovi D, Pandolfi M, Åstedt B: Local haemostasis in brain tumours. Experientia 31: 977–978, 1975 27. Tucker WS , Kirsch WM , Martinez-Hernandez A , et al : In vitro plasminogen activator activity in human brain tumors. Cancer Res 38 : 297 – 302 , 1978 Tucker WS, Kirsch WM, Martinez-Hernandez A, et al: In vitro plasminogen activator activity in human brain tumors

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Eugene A. Quindlen and Anita P. Bucher

the amount of edema seen in these types of tumors since it is often difficult with infiltrating tumors to distinguish between low density representing tumor infiltrating the parenchyma and low density representing peritumoral edema. Fig. 1. Level of tumor plasminogen activator (TPA) activity correlated with tumor type for all samples tested. The reactive gliosis sample (GLI) represents baseline tissue plasminogen activator activity. MET = metastatic tumor; AST = astrocytoma; MEN = meningioma; MED = medulloblastoma. The volume of peritumoral cerebral

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Raymond Sawaya, Mario Zuccarello and Robert Highsmith

) were positive for anti- α 1 -antitrypsin ( α 1 -AT) and Group II tumors (24 cases) were negative for anti- α 1 -AT. Values are means ± standard error of the means. PT = prothrombin time; PTT = partial thromboplastin time; ESR = electrolyte sedimentation rate; PAA = plasminogen activator activity; NS = not significant. † Edema score: 0 = no edema; 5+ = marked edema. Statistically significant differences were noted in the extent of the peritumoral edema on CT scans and the preoperative serum fibrinogen level in patients belonging in the positive α 1

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. Tibbs A. Byron Young January 1988 68 1 62 66 10.3171/jns.1988.68.1.0062 Neutron interstitial brachytherapy for malignant gliomas: a pilot study Roy A. Patchell Yosh Maruyama Phillip A. Tibbs J. Lawrence Beach Richard J. Kryscio A. Byron Young January 1988 68 1 67 72 10.3171/jns.1988.68.1.0067 Plasminogen activator activity and molecular weight patterns in human brain tumors Raymond Sawaya Robert Highsmith January 1988 68 1 73 79 10.3171/jns.1988.68.1.0073 Optic nerve decompression in

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Raymond Sawaya and Robert Highsmith

represent the total number of samples per group; molecular weight is expressed in daltons. Fig. 4. Plasminogen activator activity in extracts of human brain tumors. Bars represent the mean activity for each tumor type. Metastatic Group The metastatic group comprised 10 patients. The primary neoplasms originated from the lungs in seven patients, from an unidentified source in two, and from the kidneys in one. This group demonstrated the highest degree of PA activity, which was statistically significantly greater than the other groups with the

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Gregory R. Criscuolo, Marsha J. Merrill and Edward H. Oldfield

. Stroke 16 : 501 – 505 , 1985 Tósakí A, Koltai M, Joó F, et al: Actinomycin D suppresses the protective effect of dexamethasone in rats affected by global cerebral ischemia. Stroke 16: 501–505, 1985 31. Tucker WS , Kirsch WM , Martinez-Hernandez A , et al : In vitro plasminogen activator activity in human brain tumors. Cancer Res 38 : 297 – 302 , 1978 Tucker WS, Kirsch WM, Martinez-Hernandez A, et al: In vitro plasminogen activator activity in human brain tumors. Cancer Res 38: 297–302, 1978 32

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Kazunari Oka, Hiroko Tsuda, Kazufumi Kamikaseda, Ryuji Nakamura, Masashi Fukui, Youko Nouzuka and Katsuo Sueishi

activator activity in human brain tumors. Cancer Res 38 : 297 – 302 , 1978 Tucker WS, Kirsch WM, Martinez-Hernandez A, et al: In vitro plasminogen activator activity in human brain tumors. Cancer Res 38: 297–302, 1978 * Fibrin plates manufactured by Kowa Co., Tokyo, Japan.

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Mary E. Keohane, Scott W. Hall, Scott R. VandenBerg and Steven L. Gonias

–51, 1975 31. Rubinstein LJ , Herman MM , Foley VL : In vitro characteristics of human glioblastomas maintained in organ culture systems. Light microscopy observations. Am J Pathol 71 : 61 – 70 , 1973 Rubinstein LJ, Herman MM, Foley VL: In vitro characteristics of human glioblastomas maintained in organ culture systems. Light microscopy observations. Am J Pathol 71: 61–70, 1973 32. Sawaya R , Highsmith R : Plasminogen activator activity and molecular weight patterns in human brain tumors. J

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Raymond Sawaya, O. Juhani Rämö, Mei Lin Shi and George Mandybur

partial characterization of a plasminogen activator inhibitor from the human glioblastoma, U138. Biochem Cell Biol 66 : 1270 – 1277 , 1988 Rehemtulla A, Murphy P, Dobson M, et al: Purification and partial characterization of a plasminogen activator inhibitor from the human glioblastoma, U138. Biochem Cell Biol 66: 1270–1277, 1988 22. Sawaya R , Highsmith R : Plasminogen activator activity and molecular weight patterns in human brain tumors. J Neurosurg 68 : 73 – 79 , 1988 Sawaya R, Highsmith R: Plasminogen