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The Course of Severe Untreated Infantile Hydrocephalus

Prognostic Significance of the Cerebral Mantle

D. Yashon, J. A. Jane and O. Sugar

thickness the intellect and physical function may be practically intact. In the 15 untreated cases reported by Foltz and Shurtleff 2 no patient with a mantle under 3.0 cm. had an IQ of more than 50. They noted that the IQ may be inversely related to prolonged duration of increased intracranial pressure. They also observed that changes in the thickness of the cerebral mantle followed those in intraventricular pressure. The critical range was found to be between 120 and 140 mm. of cerebrospinal fluid. When the pressure was below the critical range the mantle was

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Hubert L. Rosomoff

cordotomy in 100 patients Complication Temporary Permanent Paresis 7 3 Ataxia 32 2 Bladder dysfunction 15 2 Sexual dysfunction 0 2 Dysesthesiae 0 0 Hypotension 4 0 Respiratory problems 2 2 The figures relating to sexual dysfunction are almost certainly inaccurate since it was most difficult to extract information on this subject from the patients. Many had lost this physical function or desire due to their disease prior to cordotomy; they were no different

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Don M. Long, David L. Filtzer, Mohammed BenDebba and Nelson H. Hendler

possible to identify when drugs were started, for how long, and in what quantities they were taken. The final area for investigation was the patient's physical function. A complete functional assessment was made by a physical therapist. All patients kept a diary of activities for 1 month prior to admission to the Pain Treatment Program. A vocational history was obtained so that it was possible to determine the nature of the event which brought on the pain-producing problem, when the patient became vocationally disabled, when the patient became functionally disabled

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Joseph Bampoe, Paul Ritvo and Mark Bernstein

Quality-of-life assessments in neurooncology are becoming more relevant with the proliferation of intensive research into brain tumors and their therapy. In this review, the authors examined several aspects and problems associated with the past, present, and future applications of quality-of-life assessments in neurooncology.

The inadequacy of the almost exclusive use of physical functioning assessments, image-documented tumor response to therapy, and patient survival time as endpoints when evaluating therapeutic regimens is becoming increasingly apparent. In therapies in which outcome using traditional endpoints are only marginally different, specific (neurological) toxicity and social and psychological outcomes must be evaluated as well to determine valid treatment options. Also becoming widely accepted is the consideration of patient values of specific health states in justifying treatment resources. There is ongoing research in brain tumor patients to address these issues.

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R. John Hurlbert, Nicholas Theodore, Janine B. Drabier, Andrea M. Magwood and Volker K. H. Sonntag

profile. The results of post hoc subsection analyses demonstrated trends toward improved scores in physical functioning, role functioning, bodily pain, general health, social functioning, vitality, emotional health, and mental health in paste-treated patients compared with placebo-treated patients. These trends were most prominent in the general health, bodily pain, and vitality categories. There was no statistically significant difference in ABPI scores between both groups (F = 1.074, df 3239; p = 0.361). The SF-36 (F = 51.675, df 3239; p < 0.001) and ABPI (F = 52

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Dorothy A. Lang, Glenn Neil-Dwyer and John Garfield

adverse events, were entered into a database. The patients were observed at 3, 6, and 12 months postoperatively, and annually thereafter. The patients completed a postoperative SF-36 questionnaire at 1 year postoperatively, and the questionnaires were analyzed by a research nurse. At this time patient GOS scores were recorded. 11 The SF-36 is a short questionnaire containing 36 items that measure eight multiitem variables covering: physical functioning, social functioning, role limitations due to physical problems, role limitations due to emotional problems, mental

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Susan R. Durham, Peter P. Sun and Leslie N. Sutton

questionnaires for a response rate of 85%. Outcome Scales The SF-36 was selected for use as a general measure of health and QOL. 35, 36 This 36-question survey measures eight health scales: physical functioning, social functioning, role limitations due to physical problems, role limitations due to emotional problems, mental health, vitality, bodily pain, and general health. In addition it has two summary scales: the PCS and the MCS. In each of these scales the scores range from 0 to 100, with higher numbers reflecting greater health. The reliability and validity of

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Robert J. Hacker

questionnaires, visual analog pain scale, and the SF-36, from which physical functioning and general mental health scores were computed. Postoperatively, all patients were evaluated at 1 and 6 weeks, and at 3, 6, 12, and 24 months, with 25 patients having extended data recorded from visits at 36 and 48 months. TABLE 1 Characteristics of 54 patients with one- or two-level cervical disease Characteristic CFC (37 patients) ACF (17 patients) p Value age 44.1 ± 7.2 44.2 ± 8.8 0.95 female 57% 59% 0.87 smoker 38

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Joseph Bampoe, Normand Laperriere, Melania Pintilie, Jennifer Glen, Johann Micallef and Mark Bernstein

in single-item analyses, the Spearman correlations between the subscale scores and KPS scores were low; ranging from −0.0056 for emotional functioning to 0.28 for cognitive functioning. Further analyses in which a repeated-measures analysis was used resulted in findings that were broadly concordant with those simpler analyses in which the Wilcoxon test was used ( Table 5 ). In addition to significant deterioration of cognitive functioning and physical experience, physical functioning was also shown to deteriorate significantly with time. Extending the period of

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Bernd O. Hütter, Ilonka Kreitschmann-Andermahr and Joachim M. Gilsbach

-related QOL, we used the ALQI, 34 which is derived from the German version of the SIP. 5, 38 The SIP is widely used in clinical outcome research and has proved to be applicable also in patients after SAH. 27 The ALQI focuses on illness-related restrictions in daily life and consists of the following 11 subscales encompassing 117 items: mobility, housework, ambulation, autonomy, and activation, which together can be aggregated into a physical function summary score; free-time activities, family relations, social contact, communication, and cognition, which can be added to