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Cheng-Bei Li, Lai-Rong Song, Da Li, Jian-Cong Weng, Li-Wei Zhang, Jun-Ting Zhang and Zhen Wu

with PIMMs, it is essential to investigate overall survival (OS) and relative risk factors that would provide meaningful reference values for clinical practice given the information asymmetry between patients and clinicians. We retrospectively reviewed our series in combination with prior cases from the literature to propose an optimal and individualized treatment paradigm for patients with PIMM. Methods Patient Population The overall cohort consisted of 2 subgroups. The first subgroup included 20 patients who were diagnosed with PIMM at the Beijing Tiantan Hospital

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Orin Bloch, Seunggu J. Han, Soonmee Cha, Matthew Z. Sun, Manish K. Aghi, Michael W. McDermott, Mitchel S. Berger and Andrew T. Parsa

G lioblastoma , the most common primary malignant brain tumor in adults, is associated with a uniformly poor prognosis. 3 , 19 Despite advances in adjuvant therapy over the past 2 decades there has been little improvement in outcomes, with the median duration of survival remaining at 12–15 months. 7 , 18 Standard therapy for newly diagnosed GBM involves resection when possible, and multiple studies over the past decade have shown that EOR is an important prognostic factor for overall survival. 6 , 8 , 12 Recently, an EOR threshold for the primary

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Debra A. Goldman, Koos Hovinga, Anne S. Reiner, Yoshua Esquenazi, Viviane Tabar and Katherine S. Panageas

treatment option at recurrence, with the goals of reducing neurological symptoms, meeting eligibility requirements for clinical trials, and extending overall survival (OS). The vast body of literature has demonstrated that repeat resection results in an OS benefit for patients with glioblastoma, 3 , 4 , 7 , 8 , 10 , 18 , 19 , 24 , 29 , 32 however, these studies only took into account repeat resection status, treating it as a standard baseline covariate, and failed to account for its timing. Both whether repeat resection occurred, and when it occurred, are required to

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Subhas K. Konar, Shyamal C. Bir, Tanmoy K. Maiti and Anil Nanda

A mong all pediatric tumors in the central nervous system, the incidence of intramedullary spinal cord tumors is less than one-third of 1%, and of these only 1%–3% are high-grade spinal tumors. 25 Pediatric glioblastoma multiforme (GBM) differs from adult GBM in tumor etiology. Pediatric infratentorial GBMs show a molecular karyotype that is more characteristic of pediatric embryonal tumors than adult GBM. 49 Overall survival (OS) and the management protocol in pediatric GBM also differ from those in adult GBM. Few studies have been published on the

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Michael C. Dewan, Gabrielle A. White-Dzuro, Philip R. Brinson, Reid C. Thompson and Lola B. Chambless

-term morbidity. 28 Perhaps most profoundly, seizures in brain tumor patients have been associated with increased disease progression and poorer overall survival. 4 , 47 These reports outline the influence of postoperative seizures on traditional provider-based measures such as neurological outcome and survival. However, the relationship between perioperative seizures and hospital quality metrics, including length of stay (LOS), hospital disposition, and readmissions has not been described. During a period of shrinking health care dollars and increased scrutiny of

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Aditya Juloori, Jacob A. Miller, Shireen Parsai, Rupesh Kotecha, Manmeet S. Ahluwalia, Alireza M. Mohammadi, Erin S. Murphy, John H. Suh, Gene H. Barnett, Jennifer S. Yu, Michael A. Vogelbaum, Brian Rini, Jorge Garcia, Glen H. Stevens, Lilyana Angelov and Samuel T. Chao

overall survival (OS). 16 , 30 , 47 Stereotactic radiosurgery (SRS) allows for the delivery of higher doses of radiation to BMs, with retrospective series reporting local control rates exceeding 80%. 8 Accordingly, SRS has become a common treatment option for select patients with RCC metastases to the brain. Radiation necrosis remains the primary dose-limiting toxicity of intracranial SRS, with prospective and retrospective studies demonstrating a 5%–10% cumulative incidence of radiation necrosis at 1 year following SRS. 9 , 33 Notably, patients with RCC appear to be

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Hannah E. Gilder, Ross C. Puffer, Mohamad Bydon and Robert J. Spinner

specifically, spinal tumors have been theorized to have a greater potential for brain metastases. Nonetheless, no published literature to date has shown a potential mechanism for these hypotheses, although CSF is the hypothesized route for malignant dissemination. 9 In this study, we sought to compare tumors with intradural extension to those remaining in the epidural or paraspinal space with the hypothesis that intradural extension may be a mechanism for seeding of the CSF with malignant cells, thereby resulting in higher rates of CNS metastases and shorter overall

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Tamara Ius, Miriam Isola, Riccardo Budai, Giada Pauletto, Barbara Tomasino, Luciano Fadiga and Miran Skrap

-weighted 3D MRI studies to plan the surgery more precisely. Patient Outcome Measurements Postoperative functional outcome was assessed using the same protocol as before surgery, during the immediate postoperative stage, and at 3 and 6 months after surgery. In addition to neurological morbidity, OS, PFS, and MPFS were assessed. Overall survival was defined as the time between initial surgery and death. Progression-free survival was defined as the time between the initial surgery and demonstration of unequivocal increase in tumor size as shown on follow-up images

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Jinho Kim, Sung-Hun Lee, Ji Hwan Jang, Mee-Seon Kim, Eun Hee Lee and Young Zoon Kim

demethylase that forms a complex with mixed lineage leukemia 4 (MLL4), an H3K4 methyltransferase, 11 and both are unique enzymes that are being fairly comprehensively studied in cancer. Therefore, we investigated the expression of these 2 enzymes and determined their clinical roles in patients with GBM. In this study, we immunohistochemically analyzed tumor samples obtained by resection to determine the prognostic value of expression of UTX (the H3K27 demethylase) and MLL4 (the H3K4 methyltransferase) for predicting progression-free survival (PFS) and overall survival (OS

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Mark B. Dekutoski, Michelle J. Clarke, Peter Rose, Alessandro Luzzati, Laurence D. Rhines, Peter P. Varga, Charles G. Fisher, Dean Chou, Michael G. Fehlings, Jeremy J. Reynolds, Richard Williams, Nasir A. Quraishi, Niccole M. Germscheid, Daniel M. Sciubba, Ziya L. Gokaslan, Stefano Boriani and The AOSpine Knowledge Forum Tumor

a mixed histology series of sarcomas, Groves et al. found that en bloc resection offered a significant survival advantage over intralesional resection. 29 Although studies remain scant and limited due to small sample sizes, by using a systematic review format and consensus recommendations Sciubba et al. strongly recommend en bloc resection for local control and possible overall survival despite very low evidence. 51 Specifically, they recommended that a multidisciplinary panel determine the feasibility of en bloc resection and that an experienced team perform