, but, based on a recently published secondary endpoint analysis of pathology concordance from NRG Oncology RTOG 0539, the WHO 2000 and 2007 standards appear to have been broadly followed, at least among institutions enrolling patients in NRG Oncology RTOG cooperative group trials. 40 Several cooperative group meningioma protocols have been launched, but they either have met with disappointing results or have failed to reach accrual goals. 10 , 21 , 25 , 27 The Southwest Oncology Group (SWOG) completed a Phase III trial, with results published in 2015 by Ji and
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Leland Rogers, Peixin Zhang, Michael A. Vogelbaum, Arie Perry, Lynn S. Ashby, Jignesh M. Modi, Anthony M. Alleman, James Galvin, David Brachman, Joseph M. Jenrette, John De Groot, Joseph A. Bovi, Maria Werner-Wasik, Jonathan P. S. Knisely, and Minesh P. Mehta
Rosemary T. Behmer Hansen, Ryan A. Behmer Hansen, Justin L. Gold, Sai Batchu, Rebecca D. Lozada, Samantha D. Palma, Stephen J. Susman, William A. Blocher III, and Angela M. Richardson
G ender differences in oncology and neurosurgery are well described. While the percentage of women in oncology fellowships closely mirrors the gender distribution of medical students at 48%, only 30% of practicing oncologists are female. 1 In contrast, comparatively fewer women than men enter neurosurgical residencies (less than 10% in 2008). 2 – 4 Gender differences persist at the faculty level: in 2014 only 8.8% of practicing academic neurosurgeons in the United States were female, and female neurosurgeons had lower rates of board certification than
Adham M. Khalafallah, Adrian E. Jimenez, Carlos G. Romo, David Olayinka Kamson, Lawrence Kleinberg, Jon Weingart, Henry Brem, Stuart A. Grossman, and Debraj Mukherjee
M ultidisciplinary treatment is increasingly common in the management of oncological conditions as the care of cancer patients continues to become more complex, necessitating the coordinated efforts of a diverse team of medical specialists. 1–4 Multidisciplinary tumor boards (MDTBs), consisting of meetings in which experts from different fields discuss patient cases and offer treatment recommendations, is one way to achieve such care coordination. Previous research has examined the efficacy of MDTBs in specialties such as gynecological oncology
Eric J. Chalif, Jacob S. Young, Genaro R. Villa, Manish K. Aghi, Jacopo Lenzi, and Mitchel S. Berger
effective and efficient than facility volume in improving care centralization for a number of common cancer types, including lung, colorectal, and others. 14 , 15 However, the utility of RSMR as a performance indicator is currently unknown for tumors of the CNS. The goal of this study was to evaluate RSMR compared with facility volume as performance indicators in surgical neuro-oncology. The primary outcome of this study was modeling the number of patients who would need to be moved from a low-performing hospital to a high-performing hospital in order to save one life
Nikita Zaborovskii, Anton Denisov, John Shapton, Adam Schlauch, Dmitrii Ptashnikov, Sergei Masevnin, Oleg Smekalenkov, Vladislav Murakhovsky, Pavel Mytyga, and Dimitriy Kondrashov
, the most validated HRQOL questionnaire specific to the metastatic spine cancer population is the Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ), 8 , 10 which was recently updated to its second version (SOSGOQ2.0). 11 The SOSGOQ2.0 contains questions that assess physical function, neurological function, pain, mental health, social function, and perceived effects of therapy on a Likert scale of 1–5. 8 It has been well validated in the English language. 11 As the number of multinational and multicultural research projects involving the spinal
Rafael De la Garza-Ramos, Mario Benvenutti-Regato, and Enrique Caro-Osorio
I n the last decades, spinal oncology has emerged as a separate subspecialty, 114 reflecting years of research focused on innovative techniques for controlling spinal tumors and managing the pain and pathophysiology arising from these types of cancers. 84 Although management of some diseases may involve few specialists, patients with spinal tumors are usually treated by a multidisciplinary team, including neurosurgeons, orthopedic surgeons, oncologists, radiation oncologists, and neurologists. 84 Thus, the spinal oncology literature encompasses numerous
Miguel Marigil and Mark Bernstein
N eurosurgery has been exponentially evolving during the last 50 years. 1 , 25 Development of tools such as neuromonitoring and neuronavigation, along with the implementation of new neuroanesthesia protocols, have helped to shorten surgical times and enhance postoperative care, enabling more rapid recovery and early discharges. 30 , 44 , 52 All of these improvements have led to a redefinition of the primary goal of care in neuro-oncology, with the aim of preserving neurological function and ultimately offering the patient a better quality of life. 16 , 26 , 31
Howard Colman, Susan M. Chang, Michael Vogelbaum, and Priscilla Brastianos
INTRODUCTION T he field of neuro-oncology continues to evolve, with ongoing advances in technology and approaches aimed at improving the diagnosis and treatment of primary and metastatic brain and spine tumors. This progress is highlighted by the recent 2021 update of the World Health Organization Classification of Tumors of the Central Nervous System. This classification represents a significant step forward in how we classify and treat primary brain tumors, with the inclusion of molecular diagnostic criteria for many different tumor types representing a
M. Peter Heilbrun and John R. Adler Jr.
radiosurgery. The primary principles of radiation therapy are embodied in the “4 Rs.” Nevertheless, there have been numerous technical advances in the field of radiation oncology, especially in the past decade, that are starting to challenge some traditional radiotherapeutic concepts. Image-guided localization, as well as better planning algorithms and field shaping, enables better control of cancerous lesions while limiting side effects to surrounding tissue, regardless of the underlying radiobiology. Most radiation oncologists have come to embrace the concept of using
Howard Colman, Manfred Westphal, and John H. Sampson
N euro-oncology is a complex field that benefits from multidisciplinary expertise from many different clinical and other specialties. The complexities in neuro-oncology stem from many sources. One of the most important sources is the complexity of the brain itself and the central role it plays in life and well being. As a result, all modalities of tumor treatment have to balance the beneficial effects of the therapy against the potential negative effects on worsening neurological deficits and/or functional status. Another complexity arises from the wide variety
