Search Results

You are looking at 1 - 10 of 350 items for :

  • "nonhuman primate" x
Clear All
Restricted access

Dali Yin, R. Mark Richardson, Massimo S. Fiandaca, John Bringas, John Forsayeth, Mitchel S. Berger and Krystof S. Bankiewicz

C onvection-enhanced delivery is a powerful methodology used for targeted gene therapy in the CNS. This technology has been investigated in canines, 3 nonhuman primates, 11 , 14 , 15 and humans. 4 , 6 , 12 , 16 We have used real-time MR imaging to monitor CED with the aid of gadoteridol, which codistributes with the therapeutic being delivered in the putamen of nonhuman primates. 9 , 15 Magnetic resonance imaging of gadoteridol is highly predictive in the determination of liposomal tissue distribution, confirmed by histological comparison following

Restricted access

Jichao Ye, Yi Qin, Yong Tang, Mengjun Ma, Peng Wang, Lin Huang, Rui Yang, Keng Chen, Chaopeng Chai, Yanfeng Wu and Huiyong Shen

in stem cell transplantation therapy due to their self-replicating ability and multidirectional differentiation potential. 18 Many studies have reported that NSC transplantation promoted the recovery of nerve function after spinal cord injury (SCI) in both rodent and nonhuman primate SCI models. For example, McDonald et al. transplanted neural differentiated mouse ESCs into rat spinal cords 9 days after traumatic injury. The authors observed that transplanted ESCs differentiated into astrocytes, oligodendrocytes, and neurons, thus promoting recovery in the injured

Restricted access

Davis P. Argersinger, Stuart Walbridge, Nicholas M. Wetjen, Alexander O. Vortmeyer, Tianxia Wu, John A. Butman and John D. Heiss

has been used in earlier animal studies to examine the effects of neurotoxin infusion on epileptic activity. 21 This technique has been studied extensively in rodents, nonhuman primates (NHPs), and humans using muscimol, a GABA-A receptor agonist. 17 , 28 , 29 BoNT/A has not been studied to the same extent. At low concentrations, BoNT/A selectively binds to the presynaptic terminals of cholinergic neurons and cleaves the synaptosomal nerve-associated protein 25 (SNAP-25) receptor. 10 The blockade of cholinergic transmission peripherally at the neuromuscular

Restricted access

Russell R. Lonser, Stuart Walbridge, Alexander O. Vortmeyer, Svetlana D. Pack, Tung T. Nguyen, Nitin Gogate, Jeffery J. Olson, Aytac Akbasak, R. Hunt Bobo, Thomas Goffman, Zhengping Zhuang and Edward H. Oldfield

-Brain Radiation Therapy ). Previous work in our laboratory had demonstrated that pentobarbital is radioprotective against the early acute and early delayed reactions of WBRT in a rat model. 37, 39, 40 Nonetheless, the effect of barbiturate medication on late delayed reactions, which cause severe late radiation syndromes, was unknown. It is this late delayed toxicity that limits the cumulative dose of radiation and therefore tumor control. To determine the potential radio-protective effects of barbiturate agents in nonhuman primates, the animals were divided into two groups

Restricted access

David I. Sandberg, M. Melissa Peet, Mark D. Johnson, Phaedra Cole, Tulay Koru-Sengul and Ali W. Luqman

peak lumbar CSF drug levels by 5- to 10-fold, and these differences were statistically significant, suggesting a potential pharmacokinetic advantage of direct-delivery chemotherapy at the site of disease origin. The primary objective of the current experiments was to assess the safety and pharmacokinetics of methotrexate infusions into the fourth ventricle in nonhuman primates. Because a much more detailed neurological examination is possible in primates than in piglets, the authors proposed that the safety of this treatment approach should be tested in primates

Restricted access

Philip A. Starr, Thyagarajan Subramanian, Roy A. E. Bakay and Thomas Wichmann

portion of the SNr—SNc complex is located immediately ventral to the STN. The physiological characteristics of both the SNr 30 and the STN 4 have been characterized in nonhuman primates in both normal and parkinsonian states, and are therefore potentially useful in guiding localization of the SNc. Other landmarks that may be of help in electrophysiological localization are the RN, thalamus, pallidal complex, striatum, and the corticobulbar and corticospinal tracts. In the experiments described here, fetal SNc allograft tissue was placed in the SNr—SNc complex in three

Full access

Yui Mano, Ryuta Saito, Yoichi Haga, Tadao Matsunaga, Rong Zhang, Masashi Chonan, Shinya Haryu, Takuhiro Shoji, Aya Sato, Yukihiko Sonoda, Noriko Tsuruoka, Keisuke Nishiyachi, Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima and Teiji Tominaga

properties of the newly developed UFD device and its efficacy by comparing the Vd after delivery using it or conventional CED in rats and nonhuman primates. Methods Assembling the UFD System Ring-shaped (outer diameter 20 mm, inner diameter 2 mm, thickness 2 mm) piezoelectric material (lead zirconate titanate [PZT]) was used ( Fig. 1 ). A metal rod was placed through the hole of the PZT ring. Conducting wires were soldered at the PZT rims. A brass horn was bonded to the ring-shaped PZT using solder. A hole was drilled at the tip of the brass horn 5 mm in depth

Restricted access

Ben Z. Roitberg, Erwin Mangubat, Er-Yun Chen, Kiminobu Sugaya, Keith R. Thulborn, Jeffrey H. Kordower, Ambarish Pawar, Todd Konecny and Marina E. Emborg

abundant, stable, and safe source of cells in order to attempt successful neurorepair. Brannen and Sugaya 4 were able to culture and differentiate fetal origin HNSCs. When implanted into older rats, these cells survived, migrated, and improved the behavioral capabilities of the animals. 21 Translation of first-in-class therapies to the clinic, especially those involving invasive surgical procedures, require assessment of feasibility, efficacy, and safety in nonhuman primate models. 1 Our group has developed a stable chronic stroke model in macaque monkeys by open

Restricted access

J Mocco, William J. Mack, Andrew F. Ducruet, Ryan G. King, Michael E. Sughrue, Alexander L. Coon, Sergei A. Sosunov, Robert R. Sciacca, Yuan Zhang, Henry C. Marsh Jr., David J. Pinsky and E. Sander Connolly Jr.

viable neuroprotective option among antiinflammatory strategies, but efforts to translate other promising antiinflammatory strategies from the laboratory to the clinical arena have failed. 7 These shortcomings highlight the difficulty of ushering therapeutic advances from rodent studies to human stroke trials. 8 , 16 This difficulty may be at least partly explained by the extensive physiological and anatomical differences between humans and rodents. As a result, nonhuman primate models of disease have become an important tool in translational stroke research

Restricted access

Jason P. Sheehan, Jonas M. Sheehan, Howard Seeherman, Mark Quigg and Gregory A. Helm

-sized defect that cannot be spontaneously bridged by bone in large, nonhuman primate species such as rhesus monkeys and baboons. 20, 21 The bone from these circular defects was discarded; the underlying dura was left intact. Then, a 3.3-cm circular absorbable collagen sponge implant that was partially (30%) loaded with 0.92 ml of 1.5 mg/ml rhBMP-2 solution (1.4 mg total dose) was placed over one of the defects. On the contralateral defect, a saline-loaded absorbable collagen sponge implant was placed. For each animal, treated and control sides were chosen at random before