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Pietro Paoletti

experimental biology of brain tumors has made important advances by the introduction of new techniques including electron microscopy, histochemistry, 7 immunology, 10 and tissue culture. 3 Experimental brain tumors 2 have been utilized, and the concepts of neurooncology have been advanced by studies of spontaneous tumors in animals. 4 Knowledge of the biochemistry of brain tumors has been expanded by the introduction of chromatography, electrophoresis, and radioactive isotopes. The subject of brain tumor metabolism has been discussed in neurosurgical meetings 6, 9 and

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Cysts in malignant gliomas

Identification by computerized tomography

Denes Afra, David Norman and Victor A. Levin

intracranial pressure and associated neurological symptoms. Clinical Material and Methods The clinical course and CT scans of 265 patients with malignant supratentorial gliomas treated on the Neuro-Oncology Service of the Brain Tumor Research Center, Department of Neurological Surgery, School of Medicine, University of California, San Francisco, were reviewed. These patients were treated between January 1, 1976, and March 1, 1978 (26 months). Diagnosis was confirmed at operation in 239 patients. All patients received both systemic chemotherapy and radiation therapy

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Richard H. Britt, Dieter R. Enzmann and Anne S. Yeager

: Corticosteroids and lymphoid cells. N Engl J Med 287: 388–397, 1972 12. Claveria LE , du Boulay GH , Moseley IF : Intracranial infections: investigation by computerized axial tomography. Neuroradiology 12 : 59 – 71 , 1976 Claveria LE, du Boulay GH, Moseley IF: Intracranial infections: investigation by computerized axial tomography. Neuroradiology 12: 59–71, 1976 13. De Armond SJ , Eng LF , Rubinstein LJ : The application of glial fibrillary acidic (GFA) protein immunohistochemistry in neurooncology

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Ronald G. Blasberg, Peter Molnar, Marc Horowitz, Paul Kornblith, Roger Pleasants and Joseph Fenstermacher

characteristics of intraparenchymal tumor growth of the RT-9 model are also observed in human neuro-oncology with the higher grade gliomas. The prominent subarachnoid spread of tumor observed in one of our animals probably reflects the reflux of tumor cells along the needle track and seeding of the subarachnoid space more than a specific characteristic of RT-9 tumor growth. Nevertheless, prominent subarachnoid expansion has been observed in some cases of human glioma. 40 Regional Blood Flow in Tumor Blood flow within the 18 RT-9 tumor foci was variable ( Figs. 4 to 6

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Immunobiology of primary intracranial tumors

Part 8: Serological responses to active immunization of patients with anaplastic gliomas

M. Stephen Mahaley Jr., G. Yancey Gillespie, Ritchie P. Gillespie, Pamela J. Watkins, Darell D. Bigner, Carol J. Wikstrand, J. Marilyn MacQueen and Fred Sanfilippo

general immune competence of brain-tumor patients. J Neurosurg 46: 467–476, 1977 17. Mahaley MS Jr , Gillespie GY : Immunologic considerations of patients with brain tumors, in Walker MD (ed): Neurooncology. Boston : Martinus-Nijihoff , 1983 Mahaley MS Jr, Gillespie GY: Immunologic considerations of patients with brain tumors, in Walker MD (ed): Neurooncology. Boston: Martinus-Nijihoff, 1983 18. March SC , Parikh I , Cuatrecasas P : A simplified method for cyanogen bromide activation of

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Philip H. Gutin, Theodore L. Phillips, William M. Wara, Steven A. Leibel, Yoshio Hosobuchi, Victor A. Levin, Keith A. Weaver and Sharon Lamb

decades, particularly in Europe, several groups have gained extensive experience with the stereotaxic implantation of radioisotopes, primarily to treat low-grade gliomas. 2, 25, 32–34 The integration of stereotaxic systems with computerized tomography (CT) scanners, with which tumor targets can be visualized and precisely implanted, 24, 26 the availability of possibly more effective radioisotopes, 16 and the development of neuro-oncology into a clinical science with emphasis on long-term follow-up review and rigid criteria of response to therapy 19 make the

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Supratentorial malignant gliomas of childhood

Results of treatment with radiation therapy and chemotherapy

Surasak Phuphanich, Michael S. B. Edwards, Victor A. Levin, Pamela S. Vestnys, William M. Wara, Richard L. Davis and Charles B. Wilson

brain tumors, 16 this therapeutic approach has been advocated for the treatment of supratentorial gliomas in children. 3, 8, 14 We report here the response to treatment of 27 children harboring supratentorial malignant gliomas who were treated on the Neuro-Oncology Service of the Brain Tumor Research Center between January, 1975, and June, 1982. Clinical Material and Methods Patient Population The patient group consisted of 10 males and 17 females younger than 18 years of age at the time of initial diagnosis (range 1.2 to 17.9 years). Histological

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Merrill J. Egorin, Edwin H. Bellis, Michael Salcman, Jerry M. Collins, James F. Spiegel and Nicholas R. Bachur

: Transplantable canine glioma model for use in experimental neurooncology. Neurosurgery 11 : 372 – 381 , 1982 Salcman M, Scott EW, Schepp RS, et al: Transplantable canine glioma model for use in experimental neurooncology. Neurosurgery 11: 372–381, 1982 43. Savaraj N , Lu K , Feun LG , et al : Intracerebral penetration and distribution of 2,5 diaziridinyl 3,6-bis(carboethoxyamino) 1,4-benzoquinone (AZQ, NSC 182986). J Neurooncol 1 : 15 – 19 , 1983 Savaraj N, Lu K, Feun LG, et al: Intracerebral penetration and

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Immunohistochemistry of central nervous system tumors

Its contributions to neurosurgical diagnosis

Jose M. Bonnin and Lucien J. Rubinstein

type that may serve as appropriate markers in the central nervous system (CNS) or elsewhere in the body, in either normal or abnormal conditions. Scope and Potential of Immunohistochemistry in Neuro-Oncology Among the nervous system markers that have been well characterized are: glial fibrillary acidic (GFA) protein; 4, 23, 25 the three subunits of neurofilaments (NF's); 84 14-3-2 protein or neuron-specific enolase (NSE); 59, 73 myelin basic protein (MBP); 9 and S-100 protein. 72 Other nervous system markers that could eventually be applied to diagnostic

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Michael Salcman, Ernesto Botero, Krishna C. V. Rao, Richard D. Broadwell and Eric Scott

microelectrodes. IEEE Trans Biomed Eng 20: 253–260, 1973 8. Salcman M , Rao KC , Scott EW , et al : CT characteristics of a transplantable canine glioma model: preliminary kinetic analysis. AJNR 4 : 786 – 788 , 1983 Salcman M, Rao KC, Scott EW, et al: CT characteristics of a transplantable canine glioma model: preliminary kinetic analysis. AJNR 4: 786–788, 1983 9. Salcman M , Scott EW , Schepp RS , et al : Transplantable canine glioma model for use in experimental neuro-oncology