right, and use of the logarithmic transformation produced histograms with the appearance of normal distributions here. Significant differences for each of these 10 variables between the two groups (laminectomy, injury, and no treatment or laminectomy, injury, and steroid treatment) were tested by separate Student's t-ratios. Correlation coefficients were computed in order to compare the recovery index with the morphometric parameters: %volume, %area, TMAS, and LMAS. Results Clinical Recovery Figure 1 plots the recovery index of both control and injured
Eugene D. Means, Douglas K. Anderson, Thomas R. Waters and Leila Kalaf
Robert S. Bourke, John B. Waldman, Harold K. Kimelberg, Kevin D. Barron, Bruce D. San Filippo, A. John Popp and Louis R. Nelson
matter edema. It is now established that, following impact spinal cord injury, 26 ischemic/hypoxic insult, 21, 25, 28, 36, 49, 50 or acceleration/deceleration injury to brain, 2, 40 there occurs early focal and scattered astroglial swelling with increases in extracellular levels of K + and increased levels of cerebral adenosine. 44 Astroglial processes normally invest more than 80% of the surface area of cerebral microvasculature. 38 Thus, swelling of astroglial processes dramatically alters intercapillary morphometrical relationships; 1 such microdistortions of
Douglas K. Anderson, Eugene D. Means, Thomas R. Waters and Evangelyn S. Green
-energy phosphate reserves and a shift in carbohydrate metabolism toward anaerobiosis. At one study time (8 hours postinjury), microvascular perfusion in injured HDMP-treated spinal cords, although subnormal, was substantially higher than similarly injured but untreated controls. In a separate study, 21 we used morphometric techniques on injured feline spinal cord and showed increased numbers of vessels in the 4 to 10 µ range for a period of 24 hours following treatment with methylprednisolone. This increase occurred at the periphery of but not in the lesioned area. In addition
Eugen J. Dolan and Charles H. Tator
-butyrolactone upon the energy metabolism of the normoxic and hypoxic rat brain. Brain Res 146: 177–187, 1978 18. Nordborg C , Johansson BB : Morphometric study on cerebral vessels in spontaneously hypertensive rats. Stroke 11 : 266 – 270 , 1980 Nordborg C, Johansson BB: Morphometric study on cerebral vessels in spontaneously hypertensive rats. Stroke 11: 266–270, 1980 19. Palleske H : Experimental investigations on the regulation of the spinal cord circulation. III. The regulation of the blood flow in the spinal
William J. Babler, John A. Persing, H. Richard Winn, John A. Jane and George T. Rodeheaver
✓ Premature closure of a cranial suture results in skull deformation characterized by inhibited skull growth in a direction perpendicular to the course of the affected suture. Early surgical release of the closed suture results in a “normal” skull morphology. The present experimental study measured alterations in growth at the transverse cranial sutures that occurred following induced premature closure of the coronal suture and its subsequent release in New Zealand White rabbits. Using roentgenocephalometric methods, growth and morphometric changes were monitored at the frontonasal, coronal, and anterior lambdoid sutures following premature closure of the coronal suture at 9 days of age. The results indicated that premature closure of the coronal suture did not result in compensatory (increased) growth at the other transverse sutures of the vault. In fact, growth at these sutures was significantly reduced. This reduced growth at adjacent transverse sutures was not ameliorated by early surgical release of the fused suture.
Comparison of percutaneous stereotaxic rhizotomy and posterior fossa exploration
Harry van Loveren, John M. Tew Jr., Jeffrey T. Keller and Mary A. Nurre
demonstrated that temperature-dependent selective destruction of A-delta and C fibers could be achieved. However, corroborating anatomical studies, including morphometric analysis of specific fiber types following radiofrequency neurolysis, have yet to be performed. Smith, et al. , 46 studied radiofrequency lesions in the peripheral nerves of the dog and found nonselective destruction of all fiber types even at low temperatures. Further investigation is warranted since these findings are not supported by the clinical observation of selective preservation of touch
Daniel L. Barrow, George T. Tindall, Kalman Kovacs, Michael O. Thorner, Eva Horvath and James C. Hoffman Jr.
transsphenoidal microsurgical approach to the sella turcica. Technical note. J. Neurosurg 49: 138–142, 1978 27. Tindall GT , Kovacs K , Horvath E , et al : Human prolactin-producing adenomas and bromocriptine: a histological, immunocytochemical, ultrastructural, and morphometric study. J Clin Endocrinol Metab 55 : 1178 – 1183 , 1982 Tindall GT, Kovacs K, Horvath E, et al: Human prolactin-producing adenomas and bromocriptine: a histological, immunocytochemical, ultrastructural, and morphometric study. J Clin Endocrinol Metab
Ronald W. J. Ford and David N. Malm
probe and Model 73A temperature controller manufactured by Yellow Springs Instrument Co., Yellow Springs, Ohio. ‖ Honeywell MFE/1000 chart recorder manufactured by Honeywell, Inc., 1100 Virginia Drive, Fort Washington, Pennsylvania. * Polar Bear Morphometric Program distributed by Computerland, Vancouver, British Columbia, Canada.
Ronald W. J. Ford and David N. Malm
manufactured by Apple Computer, Inc., Cupertino, California. ‡ Polar Bear Morphometric Program distributed by Computerland, Vancouver, British Columbia, Canada.
Masaru Inoue, Masaaki Fukushima, Kenji Tsutsumi, Shobu Shibata, Kazuo Mori and Takao Setoguchi
: [ Experimental cerebral infarction in the dog (Part 5). Four categories of infarction. ] Neurol Med Chir 22 : 262 – 266 , 1982 (Jpn) Shibata S, Tsutsumi K, Mori K, et al: [Experimental cerebral infarction in the dog (Part 5). Four categories of infarction.] Neurol Med Chir 22: 262–266, 1982 (Jpn) 27. Simionescu M , Simionescu N , Palade GE : Morphometric data on the endothelium of blood capillaries. J Cell Biol 60 : 128 – 152 , 1974 Simionescu M, Simionescu N, Palade GE: Morphometric data on the endothelium