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Intramedullary spinal cord metastasis

A clinicopathological study of 13 cases

Donal A. Costigan and Marc D. Winkelman

R ecent publications attest to a growing interest in the clinical and pathological aspects of metastasis from systemic cancer to the central nervous system (CNS). 9, 14, 19 The increased survival times of patients with certain cancers, as a result of improved treatment, has been accompanied by a greater frequency of cerebral metastases. 7, 13 Although most authorities are in agreement on the frequency of cerebral metastases 14 and on the routes of spread by which they reach the brain, 23 these aspects of intramedullary spinal cord metastasis (ISM) remain a

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Yoshihide Nagamine, Jiro Suzuki, Ryuich Katakura, Takashi Yoshimoto, Naoya Matoba, and Kiyoshi Takaya

B one metastasis from thyroid carcinoma is not uncommon, but there have been few reports of skull metastasis. Over the past 33 years, we have examined 12 patients with skull metastasis from thyroid carcinoma. Eleven of these tumors were hemispheric in shape and arose on the convexity of the skull. These skull tumors presented characteristic pathological findings. Summary of Cases During the 33 years from 1950 to 1982, 473 cases of thyroid cancer were seen at the Second Department of Surgery of Tohoku University and the Division of Neurosurgery, Institute

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Seijiro Taniura, Kyoko Tatebayashi, Kenji Watanabe, and Takashi Watanabe

I ntramedullary spinal cord metastasis is very rare, 1–8 but since the advent of MR imaging it has been found with increasing frequency. 1 There are no reports of ISCM from gastric cancer in the literature. We report our experience of a rare case, and the clinical characteristics of ICSM are discussed. Case Report History This 51-year-old woman presented to our division with a 2-month history of progressive quadriparesis. Her symptoms began as numbness in the right upper extremity that progressed over several weeks, followed by progressive weakness

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Resection for solitary brain metastasis

Role of adjuvant radiation and prognostic variables in 229 patients

Stephen R. Smalley, Edward R. Laws Jr., Judith R. O'Fallon, Edward G. Shaw, and Mark F. Schray

I ntracerebral metastatic disease is an extremely common and devastating problem. Parenchymal brain metastases are reported in approximately 10% to 15% of cancer patients both in autopsy series 32, 34 and in clinical reports. 49 This results in 100,000 to 150,000 new cases of intracerebral metastatic disease occurring each year in the United States. Furthermore, the incidence of brain metastasis appears to be increasing as a result of improved systemic chemotherapy, improved locoregional treatment modalities, and the increasing incidence of lung cancer and

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Satoshi Utsuki, Satoshi Tanaka, Hidehiro Oka, Kazuhisa Iwamoto, Takao Sagiuchi, and Kiyotaka Fujii

E xtracranial metastasis of GBM is rare, with a reported frequency of only 0.44%. 16 Usually, it occurs in regional lymph nodes (51%) and lungs and pleura (60%) and occasionally in the bone (31%) and liver (22%). 13 Bone metastasis, where the most common site is the vertebrae, is manifested as lytic or sclerotic lesions on neuroimaging. 10 Vertebral metastasis is generally seen as multiple extracranial spreading, and there has been only one reported case of isolated vertebral metastasis. 10, 11, 16, 19 We describe a case of GBM metastatic to the axis and

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Jesús Vaquero, Roberto Martínez, Santiago Coca, Santiago Oya, and Raúl Burgos

A ngiosarcomas are rare malignant tumors originating from the endothelial cells of arteries, veins, or lymphatic channels. 4 Cases of primary or secondary angiosarcoma in the central nervous system have previously been reported only exceptionally. 2, 7, 8, 10, 12 We describe a patient with a cerebral metastasis from angiosarcoma of the heart. He had previously undergone heart transplantation in attempted radical treatment of his primary tumor. Case Report This 30-year-old man underwent a thoracotomy at another hospital in February, 1989, for the

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Yoku Nakagawa, Kunio Tashiro, Toyohiko Isu, and Mitsuo Tsuru

previa. Thereafter, her menstruation was regular until the beginning of 1976, when occasional vaginal bleeding began. A chest film on February 10 showed an abnormal shadow, and the diagnosis of metastasis of chorioepithelioma was made. On April 5, 1977, lobectomy of the right upper lung and splenectomy were carried out, during which time the patient underwent chemotherapy. At laparotomy, there was no evidence of metastasis in the liver and the stomach on inspection and palpation, and the body of the uterus appeared normal. At night on June 16, 1978, the patient

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Takumi Abe, Kinya Oshida, Kiyoshi Matsumoto, Masataka Iida, and Naoko Sanno

S omatostatinomas are rare endocrine tumors that were first described in 1977; 1, 4 few cases have been reported. 2, 3 Somatostatinomas are located mainly in the pancreas, but they can also present in extrapancreatic organs such as the duodenum. 2 Metastases or local invasion are seen most frequently in the liver and lymph nodes. 2, 3 Other sites of metastasis include the peritoneum, skin, bone, kidney, ovary, adrenal gland, and thyroid gland. 3 To our knowledge, metastasis from a pancreatic somatostatinoma to the brain has not been previously described

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William T. Couldwell, Parakrama T. Chandrasoma, and Martin H. Weiss

I ntracranial metastasis from adenocarcinoma of the prostate is uncommon. Carcinoma of the prostate is the third leading cause of malignancy-related death in North American men. This malignancy has been found at autopsy in 70% of men over the age of 80 years, 8 and skeletal and pulmonary metastases predominate; intraparenchymal central nervous system metastases occur in only 0.6% to 4.4% of cases. 5, 6 A case of prostate adenocarcinoma metastasis to the pituitary gland is presented. To our knowledge this is the first reported case of symptomatic pituitary

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Dong Ah Shin, Ryoong Huh, Sang Sup Chung, Jack Rock, and Samuel Ryu

I ntradural and intramedullary metastasis consists of leptomeningeal and intramedullary metastasis. Whereas metastatic involvement is most common among the tumors arising from the spine, leptomeningeal metastasis is relatively unusual; it is observed in 4% of all spinal metastases. 18 Intramedullary metastasis is even rarer, and affects only 0.1–0.4% of all cancer patients. 3 Once the disease is diagnosed, the treatment with conventional radiation and surgery is limited and these patients have a poor prognosis. 3 , 18 Despite their rarity and poor