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Michiharu Morino, Tsutomu Ichinose, Takehiro Uda, Kyoko Kondo, Satoko Ohfuji and Kenji Ohata

occurred in the left-sided TSA group. 4 On the other hand, some studies 14 , 17 have indicated that subtemporal selective amygdalohippocampectomy, even on the language-dominant side, does not cause a significant postoperative decline in verbal memory; however, sample sizes in these studies were relatively small. Gleissner and colleagues 3 , 4 have examined memory outcome following TSA based on unrelated hippocampal histological findings, although patients without hippocampal sclerosis are known to have a poorer memory outcome than those with such induration. 27

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Takehiro Uda, Michiharu Morino, Hirotaka Ito, Noriaki Minami, Atsushi Hosono, Taiki Nagai and Takahiro Matsumoto

less invasive modification of HT (transsylvian HT) for the treatment of MTLE without hippocampal sclerosis or atrophy, and we evaluate the seizure and memory outcomes in patients treated with this procedure. This is the largest case series dealing with HT and the first report evaluating seizure and memory outcomes by using statistical methods. Methods Patient Population Between January 2005 and December 2011, 201 surgeries for drug-resistant MTLE were performed in Osaka City University Hospital and Tokyo Metropolitan neurological hospital by a single

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Taner Tanriverdi, Roy William Roland Dudley, Alya Hasan, Ahmed Al Jishi, Qasim Al Hinai, Nicole Poulin, M.Ed., Sophie Colnat-Coulbois and André Olivier

performed by the same surgeon (A.O.) at MNI. The comparison of memory outcome at 1-year follow-up of these 2 surgical techniques is the subject of this report. Methods Patient Population A list of all patients who underwent SelAH or CAH between 1986 and 1999 was obtained from the epilepsy surgery database. The patients who were included in our previously published studies 55 , 56 are not included in this study. For this study the inclusion criteria were as follows: patients who 1) were at least 16 years old; 2) had complete clinical, neuroradiological

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Eliseu Paglioli, André Palmini, Mirna Portuguez, Eduardo Paglioli, Ney Azambuja, Jaderson Costa da Costa, Hélio Fernandes da Silva Filho, José Victor Martinez and João Rubião Hoeffel

.05). Thus, in patients who had undergone surgery on the left side, there was a significant association between an SA and significant improvement in the postoperative verbal memory scores. A similar situation was not observed in patients who had undergone surgery on the right side. Entering an improvement in postoperative verbal memory scores of more than one SD as the dependent variable, the model suggests a positive association between an SA and a favorable verbal memory outcome, irrespective of the duration of follow up and side of surgery (odds ratio 1.56, 95% CI 0

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Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin and Chun Kee Chung

temporal area is critical for specific memory subfunctions, 28 , 42 only a few studies have investigated the relationship between memory outcome and resection of specific temporal areas in a way that accounts for individual differences in the extent and locus of temporal resection. 20 , 24 , 33 These studies compared resected areas based on region-of-interest (ROI) analysis at the individual level. However, direct comparison between these studies is difficult, since the atlas or segmentation methods used by ROI-based analyses were different. We hypothesized that

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Aaron A. Cohen-Gadol, Michael Westerveld, Juan Alvarez-Carilles and Dennis D. Spencer

the left hemisphere memory was superior to that of the right hemisphere and a negative difference score if the right hemisphere memory score was superior to that of the left. A similar method was used to determine lateralization based on hippocampal volumetry. Verbal Memory Outcome A verbal memory assessment was performed preoperatively and 1 year after surgery by using the VSRT. On the initial trial of the VSRT, the patient was read 12 words and was immediately asked to recall them. During subsequent trials, the patient was reminded of the words he or she

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Nicholas M. Barbaro

In their article, Hu et al. 3 have provided interesting data on the results of the 2 most commonly used approaches for treating medial temporal lobe epilepsy. They performed a meta-analysis comparing the seizure-free and memory (IQ) outcomes after anterior temporal lobectomy (ATL) versus selective amygdalohippocampectomy (SelAH). They found that ATL was more likely to result in seizure freedom than SelAH, although the percentages were similar (71% vs 66%). Fewer studies were available to compare memory outcomes, and there was no difference between the

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Naoki Tani, Haruhiko Kishima, Hui Ming Khoo, Takufumi Yanagisawa, Satoru Oshino, Tomoyuki Maruo, Koichi Hosomi, Masayuki Hirata, Hiroaki Kazui, Keiko Tokumasu Nomura, Mohamed M. Aly, Amami Kato and Toshiki Yoshimine

hippocampal sclerosis, as assessed by left hippocampal volume loss, is considered one of the predictors of memory outcome, with mild or no hippocampal sclerosis posing an increased risk of postoperative memory decline. 15 Older age at the time of surgery, late onset of seizures, and male sex are also risk factors for memory decline after left anterior temporal lobectomy. 10 , 17 Patients at high risk for postoperative memory decline may undergo the intracarotid amytal procedure (Wada test). 19 , 25 This procedure provides a reasonable index of the risk for developing

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Woorim Jeong, Hyeongrae Lee, June Sic Kim and Chun Kee Chung

have reported that there is no further decline and even improvement in episodic memory function at 1–10 years after MTLR. 1 , 2 , 19 , 28 For the purpose of better understanding memory function in TLE patients, extensive studies have investigated the neural basis of episodic memory by using functional MRI (fMRI) techniques. 4 , 11 Most previous studies, however, were conducted only to understand the neural basis of preoperative memory function and/or to unveil the preoperative predictive factors for postoperative memory outcomes by using preoperative data. A

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Mario F. Dulay and Robyn M. Busch

risk of verbal memory decline following left ATR; this finding is hypothesized to reflect reduced compensatory reserve. 8 Table 1 summarizes the presurgical predictors of postsurgical memory decline. TABLE 1: Predictors of memory outcome after ATR Predictors of Verbal Memory Decline Predictors of Visual Memory Decline dominant, lt ATR nondominant, rt ATR greater pre-ATR lt temporal lobe fMRI activation greater pre-ATR rt temporal lobe fMRI activation absence of hippocampal sclerosis larger rt hippocampus good preop