Search Results

You are looking at 1 - 10 of 84 items for :

  • "leptomeningeal disease" x
Clear All
Restricted access

Dima Suki, Hiba Abouassi, Akash J. Patel, Raymond Sawaya, Jeffrey S. Weinberg and Morris D. Groves

%) than were those who underwent resection (76%; p = 0.002); these patients were also more likely to have lesions outside the cerebellum (35 and 9%, respectively; p < 0.001). Leptomeningeal disease occurred in 33 of the 379 patients. The median time to LMD among these 33 patients was 3.7 months (range < 1–13.1 months). The cumulative proportion of LMD in the overall group, adjusted for a competing death event, was 19% (95% CI 13–26%). All 33 patients with a diagnosis of LMD after the index procedure had neuroimaging and/or CSF evidence of the disease. No patient was

Full access

Dima Suki, Rami Khoury Abdulla, Minming Ding, Soumen Khatua and Raymond Sawaya

.D. Anderson). Patients with a solid brain metastasis or leptomeningeal disease (LMD) (referred to collectively as brain metastases) whose primary cancer was diagnosed during childhood were identified from a review of the 1990–2012 Tumor Registry records at M.D. Anderson. A retrospective review of the patients' hospital records was conducted. Included in our study were patients with parenchymal, epidural, and subdural metastases. Also included were patients with calvarial and supragaleal metastases invading the epidural space or beyond and patients with leptomeningeal

Restricted access

Roshan S. Prabhu, Katherine R. Miller, Anthony L. Asher, John H. Heinzerling, Benjamin J. Moeller, Scott P. Lankford, Robert J. McCammon, Carolina E. Fasola, Kirtesh R. Patel, Robert H. Press, Ashley L. Sumrall, Matthew C. Ward and Stuart H. Burri

reduce risk of cavity LR. 14 , 16 , 19 Two recently published Phase III trials have demonstrated postoperative SRS as a potential standard of care after resection of brain metastases based on improved cavity LR rates compared with surgery alone and reduced neurocognitive deterioration compared with postoperative WBRT. 7 , 16 There has also been increasing evidence that patients treated with postoperative SRS have an increased incidence of leptomeningeal disease (LMD) recurrence, with rates of up to 30%. 13 , 16 Our group has previously demonstrated the feasibility of

Restricted access

Renee M. Reynolds, Elizabeth Boswell, Christine M. Hulette, Thomas J. Cummings, Michael M. Haglund, Elizabeth Boswell, Christine M. Hulette, Thomas J. Cumm ings and Michael M. Haglund

were not documented. To our knowledge, the present case is the first in which sudden death occurred due to diffuse leptomeningeal oligodendrogliomatosis in a patient with relatively few symptoms and without a diagnosis definitively associated with the tumor. Given the lack of pathophysiological findings in any other organ system during our patient's workup, it is likely that her oligodendrogliomatosis was the culprit. It can be hypothesized that, despite a lack of symptoms from the intracranial leptomeningeal component, her leptomeningeal disease was causing a slowly

Restricted access

Christopher S. Rumana, Kenneth R. Hess, Wei Ming Shi and Raymond Sawaya

abutting the dura are much less common. Case reports and small series have contained descriptions of subdural hematomas, 14, 22, 28, 30 neurological deficits, 10, 17 and radiographic similarity to meningiomas 5, 9, 20, 24, 26, 30 in these tumors. We have had concerns that patients with metastatic tumors with dural extension (MTDEs) would have a poorer outcome as a result of their higher incidences of recurrent disease and leptomeningeal disease relative to patients having subcortical lesions. To evaluate the clinical behavior and outcome of patients with MTDE, we

Restricted access

Neal Luther, William R. Stetler Jr., Ira J. Dunkel, Paul J. Christos, John C. Wellons III and Mark M. Souweidane

pineoblastomas were treated with standard full-dose craniospinal radiation therapy with additional boost to the primary site and chemotherapy. The use of postoperative chemotherapy and radiation was governed by the extent of resection in cases of ependymoma, and 1 patient with trilateral retinoblastoma received intensive chemotherapy only. Results Of the 40 patients who underwent this procedure, 4 had leptomeningeal disease on presentation and 4 did not meet the criterion of at least 1 month of follow-up. Among the remaining 32 patients, a high risk for leptomeningeal

Free access

Benjamin Farnia, K. Ranh Voong, Paul D. Brown, Pamela K. Allen, Nandita Guha-Thakurta, Sujit S. Prabhu, Ganesh Rao, Qianghu Wang, Zhongxiang Zhao and Anita Mahajan

was detected within the brain parenchyma. Leptomeningeal disease was defined as either presence of a positive CSF sample or imaging findings diagnostic of leptomeningeal disease. Second intraventricular metastases were defined using the same criteria as for initial metastases. Disease dissemination through the CSF was defined as the development of a second intraventricular metastastic lesion or leptomeningeal disease. To evaluate acute clinical toxicity, we reviewed symptoms and KPS scores obtained weekly during treatment and 1 month after treatment completion

Restricted access

Stephen Rush, Robert E. Elliott, Amr Morsi, Nisha Mehta, Jeri Spriet, Ashwatha Narayana, Bernadine Donahue, Erik C. Parker and John G. Golfinos

salvage GKS without surgery or WBRT. Five patients underwent resection for local failure (3 patients), resection site recurrence (1 patient), and concomitant distant and local failure (1 patient). Pathology confirmed the presence of cancer in all 5 patients (D) . Indications for WBRT included development of numerous brain metastases (in 10 patients), leptomeningeal disease (in 2), onset of numerous metastases and local failure of lesion treated with GKS (in 2), and diffuse resection cavity recurrence and new metastases (in 2). Four patients in this group had one or

Restricted access

Ben A. Strickland, Ian E. McCutcheon, Indro Chakrabarti, Laurence D. Rhines and Jeffrey S. Weinberg

outcomes of patients with IM treated surgically at our institution. Methods We queried institutional databases as well as the database of the Department of Neurosurgery at the MD Anderson Cancer Center for patients with IM who underwent resection (n = 13) between June 1, 1993, and November 30, 2014. These cases represent 0.35% of all spine operations and 4% of all intradural spinal procedures performed during the period. Patients with known leptomeningeal disease (LMD) or multiple intramedullary tumors were excluded, as was 1 patient with primary intramedullary melanoma

Restricted access

Wael Hassaneen, Dima Suki, Abhijit L. Salaskar, David M. Wildrick, Frederick F. Lang, Gregory N. Fuller and Raymond Sawaya

(intraparenchymally) in 1 patient (3%); and both locally and distantly in 3 patients (10%). One patient (3%) underwent a second operation for treatment of recurrent cerebral disease, whereas 4 (14%) underwent SRS, and 1 (3%) was treated with WBRT. Leptomeningeal disease occurred in 2 patients (7%), and was treated with chemotherapy. Specifically, with respect to the 3 patients who had undergone subtotal resection, 1 showed no tumor recurrence, and 2 of them experienced local (intraventricular) recurrence, with one undergoing SRS and the other receiving no additional treatment