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Chang-Chia Liu, Shayan Moosa, Mark Quigg, and W. Jeffrey Elias

whether direct stimulation of the anterior insula can alter cerebral pain processing in humans. The effects of anterior insula stimulation were evaluated by measuring heat pain thresholds, nociceptive-specific cutaneous laser-evoked potentials (LEPs), and continuous intracranial EEG recordings in a sample of patients with epilepsy who were undergoing intracranial monitoring for the localization of uncontrolled seizures. Methods Subjects and Intracerebral Electrode Implantation This was an early-phase, nonrandomized, serial accrual trial in which subject

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Benjamin Pommier, Charles Quesada, Camille Fauchon, Christophe Nuti, François Vassal, and Roland Peyron

hyperpathia, duration of symptoms), and 3) neurophysiological status (laser evoked potentials [LEPs] and somatosensory evoked potentials [SSEPs], classified as “normal,” “impaired,” or “abolished”). Patients with ongoing depression, mood disorders, opioid treatments, or personality disorders (as assessed in a multidisciplinary pain center including psychiatric examination) were not included in the study. Data had been prospectively collected without randomization according to a pre-established open-label therapeutic protocol. rTMS Procedure A 1 × 1 × 1–mm slice thickness 3D

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Hideki Oshima, Yoichi Katayama, Takashi Morishita, Koichiro Sumi, Toshiharu Otaka, Kazutaka Kobayashi, Yutaka Suzuki, Chikashi Fukaya, and Takamitsu Yamamoto

's disease: a study with CO2 laser evoked potentials . Pain 136 : 117 – 124 , 2008 33 Tinazzi M , Del Vesco C , Fincati E , Ottaviani S , Smania N , Moretto G , : Pain and motor complication in Parkinson's disease . J Neurol Neurosurg Psychiatry 77 : 822 – 825 , 2009 34 Witjas T , Kaphan E , Régis J , Jouve E , Chérif AA , Péragut JC , : Effects of chronic subthalamic stimulation on nonmotor fluctuations in Parkinson's disease . Mov Disord 22 : 1729 – 1734 , 2007