Search Results

You are looking at 1 - 10 of 95 items for :

  • "hyperthyroidism" x
Clear All
Restricted access

Stephen A. Hill, James M. Falko, Charles B. Wilson and William E. Hunt

spread was encountered. The management of this complex surgical problem is difficult due to aggressive tumor growth, invasion of contiguous structures, and the medical implications of thyrotoxicosis. Case Reports Case 1 This 43-year-old white woman was clinically diagnosed as acromegalic in 1960. She also had a goiter, increased radioactive iodine uptake, and an elevated protein-bound iodine test. The sella was enlarged. She was treated with irradiation, 5000 rads to the sella by linear accelerator. Because of continuing mild hyperthyroidism, she was begun on

Restricted access

Michelle J. Clarke, Dana Erickson, M. Regina Castro and John L. D. Atkinson

T hyroid-stimulating hormone pituitary adenomas are rare tumors (0.5% of all pituitary tumors 1 ) classically causing central hyperthyroidism. Central hyper-thyroidism results in thyroid gland hypertrophy and subsequent thyrotoxicosis, with elevated levels of circulating T4 and T3 and TSH levels that may be inappropriately normal or sometimes clearly elevated. Clinically silent TSH-secreting tumors can occur and are usually detected incidentally or present with mass effect, and pathological immunostaining reveals the adenoma subtype. 1 , 2 As TSH

Restricted access

Ian E. McCutcheon, Bruce D. Weintraub and Edward H. Oldfield

P ituitary adenomas that secrete thyrotropin (thyroid-stimulating hormone or TSH) are unusual endocrine lesions that comprise less than 1% of most published series of pituitary tumors. 32, 39, 44 Improvements in radiographic imaging of the sella and the development of increasingly sensitive radioimmunoassays (RIA's) for TSH and its subunits have allowed more frequent detection and diagnosis of these tumors than was possible before 1970. Their clinical manifestations are initially those of hyperthyroidism; many patients with TSH-secreting tumors are treated

Restricted access

So-Hyang Im, Chang Wan Oh, O-Ki Kwon, Jung Eun Kim and Dae Hee Han

continual stimulation of the gland without any negative feedback, thus producing hyperthyroidism. 3, 14 Concurrence of Graves disease and MMD is uncommon. In fact, to the best of our knowledge, seven cases of Graves disease coexisting with MMD have been reported in the literature since 1991. 7–10, 16 Although Graves disease often causes neuropsychiatric impairments such as dementia, depression, anxiety, irritability, and mania in the acute thyrotoxic phase, it is very rarely accompanied by cerebral ischemic accidents. 12, 13 We retrospectively reviewed four cases of

Restricted access

Shozo Yamada, Noriaki Fukuhara, Kentaro Horiguchi, Mitsuo Yamaguchi-Okada, Hiroshi Nishioka, Akira Takeshita, Yasuhiro Takeuchi, Junko Ito and Naoko Inoshita

significant. Results Patient Characteristics Demographic and clinical characteristics of our patients, including tumor characteristics, are summarized in Table 1 . The median age of our patients at the time of surgery was 42 years (range 11–74 years). Forty-seven patients (52%) were female. Signs and symptoms of hyperthyroidism were found in 83 patients ( Table 1 ). Six patients had been diagnosed with primary hyperthyroidism before being referred to our hospital. One of these patients had a previous history of radioactive iodine thyroid ablation, and 5 had

Restricted access

Joseph C. Maroon and John S. Kennerdell

✓ A surgical technique is described for radical decompression of the orbit for dysthyroid exophthalmopathy. The operation should be considered in a patient with proptosis greater than 30 mm bilaterally or one with unilateral proptosis of 10 mm or more greater than the opposite eye. Such exophthalmos is frequently associated with corneal exposure and ulceration, extreme cosmetic disfigurement, and optic neuropathy. The surgical procedure is performed through a 35-mm lateral skin incision and a lateral canthotomy with subconjunctival dissection. All four walls of the orbit are partially removed. This panorbital decompression procedure has been performed on five patients, with reduction of preoperative proptosis by as much as 17 mm. Complications were minimal. A review of the effectiveness of other orbital decompressive procedures is presented. It appears that the four-wall decompressive procedure offers the maximum degree of orbital reduction.

Restricted access

Naoko Sanno, Akira Teramoto and R. Yoshiyuki Osamura

T hyrotropin -secreting adenomas are rare, accounting for approximately 1 to 2 % of all pituitary adenomas. 2, 11, 18 The SITS by pituitary adenoma results in central hyperthyroidism, but the diagnosis may often be delayed. Such patients are often mistakenly treated for Graves disease and have long histories of thyroid dysfunction. Consequently, many thyrotropin-secreting adenomas are found when they are already large, invasive, and difficult to cure by surgery. 10, 11, 18 Most reports 10, 12, 16 describe a poor outcome from surgery, radiation therapy, or a

Restricted access

Thomas Mindermann and Charles B. Wilson

-producing pituitary adenoma was based on at least two of the following characteristics: elevated serum TSH, a history of hyperthyroidism, or immunostaining of the tumor for TSH. The follow-up period extended from the onset of symptoms until the last entry in the patient's chart. The proportion of pituitary adenomas that were TSH-producing was calculated by dividing the number of immunohistologically proven TSH-producing pituitary adenomas operated on at UCSF between 1989 and 1991 by the total number of pituitary adenomas operated on at UCSF during the same period. The statistical

Restricted access

Julio C. Antico, Luis Crovetto, Eduardo Tenca and Carlos Artes

respond to treatment with steroid agents. Moreover, all of them had previously been treated for thyrotoxicosis. The clinical and biochemical thyroid status before GKS was considered euthyroid in four patients (80%) and hyperthyroid in one patient (20%). Four patients (three women and one man) underwent unilateral treatment, whereas one underwent bilateral treatment. The average age was 56 years (range 36–70 years). Once the stereotactic frame was fixed, computerized tomography and magnetic resonance images were acquired both before and after the administration of

Restricted access

Adel M. Malek, Randall T. Higashida, Van V. Halbach, Christopher F. Dowd, Constantine C. Phatouros, Todd E. Lempert, Philip M. Meyers, Wade S. Smith and Ronald Stoney

dissections of the extracranial CA at the C2–3 level that were in different stages of healing. The clinical summary of cases is presented in Table 1 , and the clinical management is described in the following sections. TABLE 1 Demographic and clinical characteristics of three patients with strangulation-induced dissection of the cervical ICA * Characteristic Case 1 Case 2 Case 3 age (yrs), sex 37, F 43, F 24, F coexisting medical problems hypertension, hyperthyroidism hypertension, hyperthyroidism insulin-dependent diabetes mellitus,  hyperthyroidism presenting symptoms rt