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Robert J. Spinner, Bernd W. Scheithauer, Kimberly K. Amrami, Doris E. Wenger and Marie-Noëlle Hébert-Blouin

hybrid tumor. Dashed line approximates the interface between the 2 components. Printed with permission from Mayo, Copyright 2010. F = fibular head. F ig . 14. Case 13. Lipomatosis of nerve and mild nerve territory overgrowth with contiguous massive extraneural lipoma. This 47-year-old woman has both right sciatica and mild sciatic neuropathy. Her right limb was 1.5 cm longer than the left and her right foot was 1 cm larger than the left. She had calf hypertrophy. Axial T1-weighted image (A) obtained at the level of the upper thigh, showing fat

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Shih-Shan Lang, Eric L. Zager, Thomas M. Coyne, Raj Nangunoori, J. Bruce Kneeland and Katherine L. Nathanson

). INI-1 is a protein encoded by the SMARCB1 gene in which mutations have been shown to cause schwannomatosis. INI-1 expression within the nucleus is totally or partially lost in schwannomatosis. 23 F ig . 3. Immunohistochemical profile of the hybrid tumors. a–c: S100 staining of the neurofibroma (a), schwannoma tumorlet (b), and onion bulb formations (c). d: EMA staining is confined to the perineurium (arrow) . Note the negative EMA staining in the onion bulbs (asterisk) . e: CD34 staining highlighting stromal support cells and scattered vasculature