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Pieter Wesseling, Jeroen A. W. M. van der Laak, Henk de Leeuw, Dirk J. Ruiter and Peter C. Burger

production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 4 : 121 – 133 , 1993 Goldman CK, Kim J, Wong WL, et al: Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 4: 121–133, 1993 14. Haddad SF , Moore SA , Schelper RL , et al : Vascular smooth muscle hyperplasia underlies the formation of glomeruloid vascular structures of glioblastoma

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Amyn M. Rojiani and Katerina Dorovini-Zis

represent closely packed newly formed capillary buds, which are lined by hyperplastic endothelial cells that are partly invested by pericytes and devoid of astrocytic end-feet. Materials and Methods Biopsy or surgical resection specimens from 24 cases of adult supratentorial GBM treated at the Vancouver Hospital and Health Sciences Center between January 1988 and December 1989 were examined. Twelve cases showing marked vascular proliferation with formation of glomeruloid vascular structures and in which adequate tissue specimens embedded in paraffin and plastic were

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and in vivo induced by a neutralizing antibody against human basic fibroblast growth factor Nozomu Murai Tetsuya Ueba Jun A. Takahashi Hong-Qiong Yang Haruhiko Kikuchi Hiroshi Hiai Masakazu Hatanaka Manabu Fukumoto December 1996 85 6 1072 1077 10.3171/jns.1996.85.6.1072 Glomeruloid vascular structures in glioblastoma multiforme: an immunohistochemical and ultrastructural study Amyn M. Rojiani Katerina Dorovini-Zis December 1996 85 6 1078 1084 10.3171/jns.1996.85.6.1078 Transfection of IFN α

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Marsha J. Merrill and Edward H. Oldfield

glioblastoma multiforme. J Magn Reson Imaging 15 : 233 – 240 , 2002 Gossmann A, Helbich TH, Kuriyama N, Ostrowitzki S, Roberts TPL, Shames DM, et al: Dynamic contrast-enhanced magnetic resonance imaging as a surrogate marker of tumor response to antiangiogenic therapy in a xenograft model of glioblastoma multiforme. J Magn Reson Imaging 15: 233–240, 2002 54. Haddad SF , Moore SA , Schelper RL , Goeken JA : Vascular smooth muscle hyperplasia underlies the formation of glomeruloid vascular structures of glioblastoma

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Hiroaki Takeuchi, Norichika Hashimoto, Ryuhei Kitai, Toshihiko Kubota and Ken-ichiro Kikuta

, Schelper RL , Goeken JA : Vascular smooth muscle hyperplasia underlies the formation of glomeruloid vascular structures of glioblastoma multiforme . J Neuropathol Exp Neurol 51 : 488 – 492 , 1992 8 Hellström M , Kalén M , Lindahl P , Abramsson A , Betsholtz C : Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse . Development 126 : 3047 – 3055 , 1999 9 Hilberg F , Roth GJ , Krssak M , Kautschitsch S , Sommergruber W , Tontsch