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Transcortical insular glioma resection: clinical outcome and predictors

N. U. Farrukh Hameed, Tianming Qiu, Dongxiao Zhuang, Junfeng Lu, Zhengda Yu, Shuai Wu, Bin Wu, Fengping Zhu, Yanyan Song, Hong Chen, and Jinsong Wu

T he insula is a pyramid-shaped lobe of the brain that forms part of the limbic and paralimbic systems, and brain functions ranging from cognitive to language and motor functions can be traced directly or indirectly to the insular region. 30 Insular gliomas are the most common intrinsic tumors of this region, however, due to their depth and impinging neural networks, insular gliomas are dangerous to resect and have always challenged neurosurgeons. Despite this, the standard management of insular gliomas continues to remain maximum resection followed by

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Metabolic approach for tumor delineation in glioma surgery: 3D MR spectroscopy image–guided resection

Jie Zhang, Dong-Xiao Zhuang, Cheng-Jun Yao, Ching-Po Lin, Tian-Liang Wang, Zhi-Yong Qin, and Jin-Song Wu

G liomas are the most common primary brain tumors, accounting for 80% of malignant central nervous system tumors, and can be categorized into 4 grades according to their biological behavior. Patients with low-grade gliomas (LGGs) typically survive more than 5 years. 21 Those with high-grade gliomas (HGGs) have a survival time of approximately 1–3 years. An epidemiology study using primary brain tumor data collected from 1985 to 2005 showed that the 1-year survival rate of patients with malignant glioma is 53.9%, while that of patients with glioblastoma is

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Familial gliomas

Report of four cases

Howard H. Kaufman and Ronald Brisman

posterior fossa, one with malignant histological characteristics and the other relatively benign and cystic. Discussion Although many cases of familial gliomas have been reported, 1, 11, 17 the question remains as to whether the familial occurrence is due to chance alone or to genetic factors. Hauge and Harvald 8 reviewed almost 4000 relatives of over 300 families in which gliomas occurred, together with 2000 relatives in about 250 normal families; they concluded that “… familial occurrence of gliomata and meningiomata seems to be a rare phenomenon

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Association between small heat shock protein B11 and the prognostic value of MGMT promoter methylation in patients with high-grade glioma

Wen Cheng, Mingyang Li, Yang Jiang, Chuanbao Zhang, Jinquan Cai, Kuanyu Wang, and Anhua Wu

G lioma is the most common type of tumor in the CNS. The WHO classifies glioma on a scale of Grades I-IV, according to histopathologic features. 28 Grades in and IV are progressive, resistant to treatment, and grouped together as high-grade glioma (HGG) for the purposes of clinical management. Glioblastoma and anaplastic glioma comprise the majority of HGG cases. Since the incorporation of alkylating agents such as temozolomide (TMZ) into routine chemotherapy, the prognosis for patients with HGG has significantly improved. The epigenetic silencing of O 6

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Meningeal invasion by gliomas

Gerald D. Silverberg and John W. Hanbery

I t is well established that many tumors of the central nervous system other than meningiomas may present as a meningeal mass. 13 That these tumors might manifest a clinical history, radiographic picture, gross surgical appearance, and even a microscopic appearance similar to a primary tumor of the meninges, probably needs periodic reemphasis. In 1931 Cairns and Russell 2 carefully studied and reported eight of 22 gliomas that had invaded the meninges and proliferated to a variable extent in the subarachnoid space. They noted that there is often a

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Coincidental meningioma and glioma

Report of two cases

Anthony J. Strong, Lindsay Symon, Beth J. L. MacGregor, and Brian P. O'Neill

T he occurrence of multiple meningiomas or gliomas is a well recognized feature of the central form of neurofibromatosis, 15, 16, 18 and either multiple meningiomas 10, 12 or multiple gliomas 4, 9 have also been recorded in patients without this predisposition. However, the occurrence in a single patient of a meningioma and glioma, each solitary, is observed less frequently. 1, 3, 5–8, 11, 14, 17 We wish to report two cases in both of which a single meningioma and glioma were present. The anatomical and clinical presentations, which differed in each

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Chemotherapy for malignant gliomas

Paul L. Kornblith and Michael Walker

I n the past decade, there has been increased interest in the role of chemotherapy in the treatment of malignant tumors of the brain and spinal cord. The major focus of the effort to develop chemotherapy programs has been on the malignant gliomas. Although some series of cases have been reported involving other types of central nervous system neoplasia, the series are too small and the data not subjected to careful controls. Thus, the emphasis in this review will be on the role of chemotherapy as an adjunct in the treatment of malignant gliomas of the brain

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Contribution of combined intraoperative electrophysiological investigation with 3-T intraoperative MRI for awake cerebral glioma surgery: comprehensive review of the clinical implications and radiological outcomes

Diana Ghinda, Nan Zhang, Junfeng Lu, Cheng-Jun Yao, Shiwen Yuan, and Jin-Song Wu

T he natural history of brain gliomas has been extensively studied. Multiple studies have demonstrated the benefits of radical surgery in terms of overall outcome and recurrence-free survival. 2 , 4 , 13–15 , 22 , 28–30 , 32 , 34 Although there is currently a lack of Class I evidence, these studies suggest a survival benefit derived from maximal resection for both low-grade gliomas (LGGs) and high-grade gliomas (HGGs). Current technological improvements, such as 5-aminolevulinic acid fluorescence and intraoperative MRI (iMRI), circumvent the brain shift

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Solitary primary intracranial extracerebral glioma

Case report

Samruay Shuangshoti, Vira Kasantikul, Nitaya Suwanwela, and Charas Suwanwela

T o our knowledge, 17 gliomas arising primarily within the leptomeninges have been reported. Eleven of these were intracranial 1, 2, 5, 7, 8, 10, 21 and six were intraspinal. 3, 9, 16 Of the 11 intracranial leptomeningeal gliomas, two astrocytomas 7, 21 and one oligodendroglioma 10 spread diffusely over the brain surface creating the leptomeningeal gliomatosis; the remaining eight gliomas were solitary. 1, 2, 5, 8 All six intraspinal leptomeningeal gliomas (three astrocytomas, 3, 9 two ependymomas, 3 and one mixed astrocytoma and ependymoma, 16 ) were

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Enolase isoenzymes in human gliomas

Ernst M. H. van den Doel, Gert Rijksen, Paul J. M. Roholl, Cees W. M. van Veelen, and Gerard E. J. Staal

-cell carcinomas of the pancreas, and carcinomas of the gut. 9, 10, 21–24, 35, 42 Studies, mainly immunohistochemical, of human gliomas have given conflicting results regarding the presence of γ-enolase in the tumor tissue. 21, 27, 36, 39 Taking histopathological structure and the varying biological behavior of human gliomas into consideration, γ-enolase could be expected in at least some of these tumors. In addition, cultured glioma cells have been found to contain γ-enolase. 40 To clarify these various findings, we studied human gliomas with a combination of