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Familial gliomas

Report of four cases

Howard H. Kaufman and Ronald Brisman

posterior fossa, one with malignant histological characteristics and the other relatively benign and cystic. Discussion Although many cases of familial gliomas have been reported, 1, 11, 17 the question remains as to whether the familial occurrence is due to chance alone or to genetic factors. Hauge and Harvald 8 reviewed almost 4000 relatives of over 300 families in which gliomas occurred, together with 2000 relatives in about 250 normal families; they concluded that “… familial occurrence of gliomata and meningiomata seems to be a rare phenomenon

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Gerald D. Silverberg and John W. Hanbery

I t is well established that many tumors of the central nervous system other than meningiomas may present as a meningeal mass. 13 That these tumors might manifest a clinical history, radiographic picture, gross surgical appearance, and even a microscopic appearance similar to a primary tumor of the meninges, probably needs periodic reemphasis. In 1931 Cairns and Russell 2 carefully studied and reported eight of 22 gliomas that had invaded the meninges and proliferated to a variable extent in the subarachnoid space. They noted that there is often a

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Anthony J. Strong, Lindsay Symon, Beth J. L. MacGregor, and Brian P. O'Neill

T he occurrence of multiple meningiomas or gliomas is a well recognized feature of the central form of neurofibromatosis, 15, 16, 18 and either multiple meningiomas 10, 12 or multiple gliomas 4, 9 have also been recorded in patients without this predisposition. However, the occurrence in a single patient of a meningioma and glioma, each solitary, is observed less frequently. 1, 3, 5–8, 11, 14, 17 We wish to report two cases in both of which a single meningioma and glioma were present. The anatomical and clinical presentations, which differed in each

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Paul L. Kornblith and Michael Walker

I n the past decade, there has been increased interest in the role of chemotherapy in the treatment of malignant tumors of the brain and spinal cord. The major focus of the effort to develop chemotherapy programs has been on the malignant gliomas. Although some series of cases have been reported involving other types of central nervous system neoplasia, the series are too small and the data not subjected to careful controls. Thus, the emphasis in this review will be on the role of chemotherapy as an adjunct in the treatment of malignant gliomas of the brain

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Samruay Shuangshoti, Vira Kasantikul, Nitaya Suwanwela, and Charas Suwanwela

T o our knowledge, 17 gliomas arising primarily within the leptomeninges have been reported. Eleven of these were intracranial 1, 2, 5, 7, 8, 10, 21 and six were intraspinal. 3, 9, 16 Of the 11 intracranial leptomeningeal gliomas, two astrocytomas 7, 21 and one oligodendroglioma 10 spread diffusely over the brain surface creating the leptomeningeal gliomatosis; the remaining eight gliomas were solitary. 1, 2, 5, 8 All six intraspinal leptomeningeal gliomas (three astrocytomas, 3, 9 two ependymomas, 3 and one mixed astrocytoma and ependymoma, 16 ) were

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Ernst M. H. van den Doel, Gert Rijksen, Paul J. M. Roholl, Cees W. M. van Veelen, and Gerard E. J. Staal

-cell carcinomas of the pancreas, and carcinomas of the gut. 9, 10, 21–24, 35, 42 Studies, mainly immunohistochemical, of human gliomas have given conflicting results regarding the presence of γ-enolase in the tumor tissue. 21, 27, 36, 39 Taking histopathological structure and the varying biological behavior of human gliomas into consideration, γ-enolase could be expected in at least some of these tumors. In addition, cultured glioma cells have been found to contain γ-enolase. 40 To clarify these various findings, we studied human gliomas with a combination of

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Andrew G. Lee

O ptic pathway gliomas are slow-growing neoplasms that may cause visual or neurological complications and death. They are typically described by location as involving the optic nerve or optic chiasm, and may affect the hypothalamus or third ventricle, producing hydrocephalus. Posterior visual pathway involvement may also occur in patients with OPGs. Dutton 30 reviewed the literature concerning OPGs through 1994 and summarized the clinical characteristics ( Table 1 ). Lee and Dutton 51 updated this literature review in 1999. The present study includes

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Tsuyoshi Matsumoto, Eiichi Tani, Keizo Kaba, Hideki Shindo, and Katsuya Miyaji

multidrug resistance by several agents, including verapamil; 38, 42 4) an increased amount of P-glycoprotein, a product of multidrug resistance 1 (mdr1) gene; 22, 32, 40 and 5) amplification or overexpression of the mdr1 gene. 12, 14, 26–28, 31, 33, 41 In our previous studies, 20, 24 a multidrug-resistant human glioma cell line showed a decreased intracellular accumulation of agents mediated by an increased drug efflux, a reversal of multidrug resistance by calcium channel blockers, and a good correlation between the level of mdr1 gene transcript and the extent

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Vidar Bosnes and Henry Hirschberg

L ymphokine-activated killer (LAK) cells are generated when peripheral blood mononuclear cells (PBMC) from normal subjects or cancer patients are stimulated with interleukin-2 (IL-2) for 2 days or more. 8 These cells show strong cytotoxicity against a wide range of target cells, notably against malignant cells. It has been demonstrated that LAK cells can be generated from the PBMC of glioma patients, 1, 13 and clinical trials of immunotherapy using LAK cells in the treatment of malignant glioma have also been started. 11, 12, 14 The fact that LAK cells can

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Vincent C. Ye, Alexander P. Landry, Teresa Purzner, Aristotelis Kalyvas, Nilesh Mohan, Philip J. O’Halloran, Andrew Gao, and Gelareh Zadeh

Although brainstem gliomas have received considerable attention in the pediatric population, they represent only 1%–2% of gliomas in the adult population 1 and thus remain poorly understood. It is also becoming increasingly clear that the biological landscape of gliomas depends largely on patient age group (pediatric versus adolescent versus adult), 2 and thus each must be studied independently. Notably, brainstem gliomas portend a better prognosis (median survival 30–40 months) in the adult population than that of their supratentorial