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Kyung Sun Song, Ji Hoon Phi, Byung-Kyu Cho, Kyu-Chang Wang, Ji Yeoun Lee, Dong Gyu Kim, Il Han Kim, Hyo Seop Ahn, Sung-Hye Park and Seung-Ki Kim

G lioblastoma is one of the most lethal and most common primary brain tumors in adults. Most patients with glioblastoma experience a recurrence within several months, despite extensive surgery and radiation therapy. The median OS of patients with a newly diagnosed glioblastoma is 11.0–14.6 months, and the 2-year actuarial survival rate is only 16.0%–26.5%, despite the advances in multimodality treatments. 15 , 20 However, these figures stem from cohorts of adult patients. Non–brainstem glioblastoma is rare in the pediatric population compared with its

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Javier M. Figueroa and Bob S. Carter

B iofluid -based detection of glial tumors offers multiple approaches for improving quality of life in patients with glioblastoma (GBM). Many screening approaches take advantage of a slow initial phase of tumor growth for early detection, before a tumor has reached a greater degree of malignant potential. For example, in the more common malignancies such as breast and colon cancer, the early discovery of solid tumors with the development of mammography and colonoscopy screenings is a well-established clinical paradigm. In terms of malignant glial tumors (such as

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Brandyn A. Castro and Manish K. Aghi

D espite aggressive management with surgery, chemotherapy, and radiation at the time of diagnosis, and continued aggressive treatment with surgery and novel chemotherapy regimens at recurrence, the prognosis for glioblastoma, although improved compared with less than a decade earlier, 77 remains poor at just shy of 2 years. 21 Conventional DNA-damaging chemotherapies may exhibit limited duration of efficacy due to the emergence of mutations promoting drug resistance. 57 The highly vascular nature of glioblastomas makes them a prime target for treatment

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Guido Reifenberger, Jan Boström, Martin Bettag, Wolfgang J. Bock, Wolfgang Wechsler and John J. Kepes

. The tumor does not cross the interpeduncular fossa, and the right oculomotor nerve is completely normal. Masson's trichrome stain, original magnification × 35. g: Higher-magnification view of the tumor at autopsy corroborating the diagnosis of glioblastoma multiforme. Note areas of coagulation necrosis. H & E, original magnification × 120. h: Neuroglial islands (arrows) visible in the proximal portion of an oculomotor nerve obtained at autopsy from a neurologically normal adult brain. H & E, original magnification × 300. nec = necrosis; NIII = oculomotor nerve; tu

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Robert C. Rennert, Reid R. Hoshide, Jason W. Signorelli, Deirdre Amaro, Jayson A. Sack, Cameron W. Brennan and Clark C. Chen

report the case of an unfortunate patient who suffered from a widely metastatic glioblastoma. DNA copy number microarray (OncoScan, Affymetrix) profile of the resected specimen revealed chromothripsis of chromosome 6. Such a chromothripsis pattern was not found in 50 nonmetastatic glioblastomas treated at the senior author's institution. One comparable case of chromosome 6 chromothripsis was seen in 1000+ gliomas within The Cancer Genome Atlas (TCGA) data set, and the patient with this condition died within 6 months of undergoing tumor resection. Given previous reports

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Joseph F. Cusick, Senichiro Komacki and Hongyung Choi

early postoperative period. We are reporting a case of a left superficial temporal branch of the external carotid artery anastomosis to a temporal cortical branch of the middle cerebral artery. A glioblastoma multiforme tumor formed at the site of the fully functioning anastomosis 9 months postoperatively. Case Report This 59-year-old man had two episodes of transient ischemic attacks consisting of dysphasia and weakness of the right side of his face, right arm, and leg over a 2-year period. Two days before admission, he suffered a similar episode which

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Diane J. Aum, David H. Kim, Thomas L. Beaumont, Eric C. Leuthardt, Gavin P. Dunn and Albert H. Kim

G lioblastoma is the most common primary malignant brain tumor in adults and continues to portend poor prognosis despite decades of research. Even with aggressive resection followed by concomitant chemotherapy and radiation, there is a high recurrence rate with median survival of less than 15 months. 58 Indeed, fewer than 5% of patients survive 5 years. 45 Extensive investigation of the cellular and molecular biology of glioblastoma over the last decade has identified several histopathological and chromosomal hallmarks that have enhanced diagnosis and

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Bo Wu, Weidong Liu, Hong Zhu, Hailong Feng and Jinping Liu

G lioblastomas represent 15%–20% of all intracranial tumors and account for approximately 50% of all gliomas in adults. 10 These tumors are located most frequently in the cerebral hemispheres, basal ganglia, thalamus, and corpus callosum. 18 , 21 Only rarely do they grow primarily within the posterior fossa in adults, and they infrequently exhibit exophytic growth patterns but usually protrude dorsally. 7 , 8 Recently, Luetjens et al. 16 reported on a 40-year-old man who presented with a large exophytic giant cell glioblastoma of the medulla oblongata

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Panagiotis Mastorakos, Michael A. Hays, James P. Caruso, Ching-Jen Chen, Dale Ding, Davis G. Taylor, M. Beatriz Lopes and Mark E. Shaffrey

of less than 2 years. 35 , 37 These tumors are frequently misdiagnosed as inflammatory or nongliomatous neoplastic processes on initial presentation; thus, a biopsy is often required to confirm the diagnosis. 24 , 28 While malignant gliomas are considered a diffusely disseminated disease, tumor recurrence most frequently occurs locally, with reported rates ranging from 70% to 100%. 8 , 20 As reported by Sherriff et al., the majority of supratentorial glioblastomas with recurrence were observed in the ipsilateral hemisphere, and only 4% of the total recurrences

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Sameer Agnihotri, Kenneth D. Aldape and Gelareh Zadeh

, Hartmann C , von Deimling A : Analysis of the IDH1 codon 132 mutation in brain tumors . Acta Neuropathol 116 : 597 – 602 , 2008 3 Bettegowda C , Agrawal N , Jiao Y , Sausen M , Wood LD , Hruban RH , : Mutations in CIC and FUBP1 contribute to human oligodendroglioma . Science 333 : 1453 – 1455 , 2011 4 Bhat KP , Balasubramaniyan V , Vaillant B , Ezhilarasan R , Hummelink K , Hollingsworth F , : Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma . Cancer Cell 24 : 331 – 346