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Donald D. Matson and Francis D. L. Crofton

of cerebrospinal fluid and communicating hydrocephalus. There would seem to be no way to differentiate such a lesion from a papilloma except by pathological examination. Only a few cases have been reported in the literature. 9, 35, 38 Gangliogliomas occurring in the lateral ventricle have been seen at least 5 times in our experience in children. These usually have been associated with intracranial calcification and with an obstructive local hydrocephalus rather than the communicating variety. There usually have been other stigmata of tuberous sclerosis also in

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Jack E. Sinclair and Yong H. Yang

response was extensor on the right. The spasm of the right lower extremity had decreased markedly. There was a dermatomal distribution of sensory loss on the right of C2 and (subtotal) C3, and on the left of C3. COMMENT Synonyms for ganglioneuroma are gangliocytoma, ganglioglioma, true neuroma, glioneuroblastoma, neurastrocytoma, ganglioma, Pur kinjeoma, etc. By anatomical location three classes are distinguished: (1) of the cerebral hemispheres, brain stem and spinal cord; (2) of the cerebellum; and (3) of the sympathetic trunk. The age of greatest incidence

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Ulrich Batzdorf and Nathan Malamud

other figures in this table by including only gliomas, and only those cases verified at autopsy. † Courville's series of 492 cases included 269 “gliomas,” from which pinealomas, gangliogliomas and medulloblastomas have been eliminated in order to bring the figures into agreement with the other figures in this table. Following the monumental study by Bailey and Cushing, 2 our knowledge of the mode of growth and spread of gliomas became more precise. 11, 25, 26, 36, 44–46, 54, 55, 66–68 Although relatively little information about the general

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Mehdi Moghimi

The first reported case was in 1914 by Schmincke, 4 who used the term “ganglioneuroma amyelineum.” Later a few other authors, describing histologically identical tumors, used the terms of “ganglioglioma,” “ganglioglioneuroma,” “spongioblastoma,” “spongioneuroblastoma” and “retothelial sarcoma.” In 1956 Zülch 4 interpreted tumors of this type as arising from the cerebral blood vessels and called them “monstrocellular sarcoma.” Among 2,250 brain tumors, he classified 17 as “monstrocellular sarcoma,” with an incidence of 0.8 per cent. Three of these 17 growths

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Robert H. Wilkins and Guy L. Odom

Diagnosis and distribution of patients with intracranial neoplasm Diagnosis Number of Patients Average Age (yrs.) Sex CSF Specimens Male Female No. Average Amount of Sample (ml.) 1. Benign  a. Astrocytoma 9 28 5 4 40 16  b. Ependymoma 4 21 1 3 12 16  c. Oligodendroglioma 2 39 0 2 7 20  d. Spongioblastoma 1 11 1 0 4 21  e. Ganglioglioma 1 18 1 0 7 6  f. Mixed glioma 3 30 2 1 20 26  g

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Glial Origin of Monstrocellular Tumor

Case Report of Prolonged Survival

Donald P. Becker, Robert Benyo and Uros Roessmann

cells to be ganglion cells. However, some of the giant cells demonstrated glial foot processes attached to blood vessels. Basically the tumor had all the characteristics of a glioblastoma. Four further reports of “immature gangliogliomas” appeared. 4, 5, 9, 13 Foerster and Gagel 5 noted glial fibrils and astrocytes in their case report and would have called the tumor a glioblastoma were it not for the “ganglion cells.” However, in 1936, Scherer 11 clearly demonstrated in his report of two cases that the giant cells were of glial and not neuronal origin. Foot and

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F. A. Durity, C. L. Dolman and P. D. Moyes

, D. H. The urinary excretion of vanilmandelic acid (VMA) and homovanillac acid (HVA) in children with retinoblastoma. Am. J. Ophthal. , 1966, 61: 239–243. 4. Christian , H. J. So-called “gangliocytoma” of the cerebellum. Report of a case. J. Neurosurg. , 1961 , 18 : 125 – 128 . Christian , H. J. So-called “gangliocytoma” of the cerebellum. Report of a case. J. Neurosurg. , 1961, 18: 125–128. 5. Courville , C. B. Ganglioglioma. Tumor of the central nervous system; review of the literature and report of

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Larry K. Page, Cesare T. Lombroso and Donald D. Matson

Name Sex Age at: Tumor Location Tumor Type Result Length of Follow-Up Onset of Seizures Diagnosis of Tumor J.M. M 3 Mos. 5 Yrs. Lt. Frontal Ganglioglioma Dead 1 Mo. T.F. M 10 Mos. 10 Yrs. Lt. Intraventricular Ganglioglioma Dead 1 Mo. A.N. M 1 Yr. 2 Mos. 7 Yrs. 6 Mos. Third Ventricalar Ganglioglioma Dead 2 Mos. B.S. M 1 Yr. 4 Mos. 14 Yrs. 2 Mos. Lt. Parietal Astrocytoma Grade II Alive 3 Yrs. 6 Mos. P.B. M 2 Yrs. 7 Yrs. 6 Mos. Rt. Parietal Astrocytoma

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Mary L. Voorhess and E. Sidney Watkins

reaction. J. Neuropath. exp. Neurol. , 1966 , 25 : 328 – 340 . Miller , A. A., and Ramsden , F. A cerebral neuroblastoma with unusual fibrous tissue reaction. J. Neuropath. exp. Neurol. , 1966, 25: 328–340. 5. Russell , D. S. , and Rubinstein , L. J. Ganglioglioma: A case with long history and malignant evolution. J. Neuropath. exp. Neurol. , 1962 , 21 : 185 – 193 . Russell , D. S., and Rubinstein , L. J. Ganglioglioma: A case with long history and malignant evolution. J. Neuropath. exp. Neurol. , 1962, 21

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Jack R. Cooper

. References 1. Albrecht E : Ueber Hamartome. Verh Deutsch Ges Path 7 : 153 – 157 , 1904 Albrecht E: Ueber Hamartome. Verh Deutsch Ges Path 7: 153–157, 1904 2. Anderson FM , Adelstein LJ : Ganglion cell tumor (ganglioglioma) in the third ventricle: operative removal with clinical recovery. Arch Surg 45 : 129 – 139 , 1942 Anderson FM, Adelstein LJ: Ganglion cell tumor (ganglioglioma) in the third ventricle: operative removal with clinical recovery. Arch Surg 45: 129–139, 1942 3