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The Chemotherapy of Intracranial Infections

IV. The Treatment of Pneumococcal Meningitis by Intrathecal Administration of Penicillin

Cobb Pilcher and William F. Meacham

. Rammelkamp , C. H., and Keefer , C. S. The absorption, excretion and toxicity of penicillin administered by intrathecal injection. Amer. J. med. Sci. , 1943, 205: 342–350. * The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the Vanderbilt University. The penicillin was furnished by E. R. Squibb and Sons and by Charles Pfizer, Inc., New York, on recommendation of the Committee on Chemotherapeutic and Other Agents of the National

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The Lucite Calvarium—A Method for Direct Observation of the Brain

I. The Surgical and Lucite Processing Techniques

C. Hunter Shelden, Robert H. Pudenz, Joseph S. Restarski and Winchell McK. Craig

INTRODUCTION O bservations of the living brain through a cranial window have been periodically reported since Ravina described his original procedure in 1811. 5 With the passage of time improvements in the design of these windows have been instituted according to the nature and duration of the proposed experiments. In the earlier investigations windows were usually devised for temporary emplacement into skull openings. More recently, workers have directed their efforts toward the development of more permanent windows. In this communication a technique is

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Gilbert Horrax

victims who survived the hemorrhage were destined to various states of spastic paraplegia, usually with seriously impaired mentality, blindness and other evidences of cerebral damage. Cushing was able to report four operative cases with two recoveries from serious subdural hemorrhage in infants from three to eight days old. Subsequently (1910) 15 he reported 12 further cases with recoveries in about half the patients and without the development of spastic paraplegia. In this second article he likewise stated that one of the infants upon whom he had operated in 1905

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The Use of Products Prepared from Human Fibrinogen and Human Thrombin in Neurosurgery

Fibrin Foams as Hemostatic Agents; Fibrin Films in Repair of Dural Defects and in Prevention of Meningocerebral Adhesions

Franc D. Ingraham and Orville T. Bailey

INTRODUCTION D uring the past forty years neurosurgical operations have developed from hazardous and rarely successful tours de force to well standardized and relatively safe procedures. Many of the major contributions to this rapid development are due to the investigations and teaching of Harvey Cushing. By adapting techniques of general surgery to the particular requirements of the neurosurgeon and by the development of new techniques to meet problems not encountered in other fields of surgery his work was a definitive influence in modern }neurosurgery

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task throughout—involving the construction of 93 separate units of permanent masonry work, constituting the largest unit under one roof in Massachusetts. The newest practical developments of medical science and engineering skill have been incorporated into the design and construction of this medical center. It has afforded Colonel Gillette and me great satisfaction to know that this task has been commended by the Surgeon General and the Chief of Engineers and has been suggested as a model for others to follow. This hospital is to be named for Doctor Harvey Cushing

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Claude C. Coleman

later direct suture more difficult and sometimes impossible. In median and ulnar lesions, delayed nerve repair allows for the development of advanced atrophy of the intrinsic hand muscles, periarticular fibrosis and other crippling effects which permanently mar the results of later suture. We are more concerned at the present time with nerve lesions produced by gunshot wounds of the extremities. The diagnosis of nerve lesions in such conditions must take into consideration certain concussional effects of missiles of high velocity which may cause a temporary

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A. Earl Walker, Jerry J. Kollros and Theodore J. Case

content after experimental concussion. Ann. Surg. , 1943, 118: 619–634. 25. Williams , D. , and Denny-Brown , D. Cerebral electrical changes in experimental concussion. Brain , 1941 , 64 : 223 – 238 . Williams , D., and Denny-Brown , D. Cerebral electrical changes in experimental concussion. Brain , 1941, 64: 223–238. * The work described in this paper was done under a contract recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the University of

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Burton M. Shinners and Wallace B. Hamby

all stages of the development of our knowledge of this lesion. There were 140 patients explored, and 160 operations were performed, 20 patients having two operations. There have been no fatalities and one mild wound infection. In 116 patients protruded discs were found at the first operation. In 8 patients recurrences were subsequently found at the same level. In 3 patients second disc protrusions were found at a new level. These total 127 examples of disc protrusion. Twenty-four of the 140 patients (17 per cent) were explored without discovery of disc protrusions

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Andrew J. Akelaitis

possibility that interhemispheral fibers occurring in commissural pathways other than the anterior commissure and corpus callosum play a prominent part in the connections between the dominant and subordinate hemispheres. There is little doubt regarding the dominance of the left hemisphere for language in this patient because of the previous history of a transient aphasia with the development of a brain abscess in the left frontal lobe. Case 2 is unique for three reasons. First, in view of the fact that the operation was performed under local anesthesia, it was possible to

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Murray A. Falconer and Dorothy S. Russell

disturbance. Their intimate association with herniation of the brain at the same site suggested that the mechanism might be a venous obstruction arising through compression of the superficial cerebral veins against the margins of the bony opening. This might in particular operate in respect of the larger veins proceeding towards the superior longitudinal sinus, especially as the hernia invariably showed its greatest development along the medial border of the opening. To test this theory we made the following experiments: I. In 4 rabbits a small burr-hole, less than 5