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Chao-hu Wang, Song-Tao Qi, Jun Fan, Jun Pan, Jun-Xiang Peng, Jing Nie, Yun Bao, Ya-Wei Liu, Xi’an Zhang and Yi Liu

44− ACP cells did not form tumors (0/6 mice) at any of the injected dilutions. In contrast, the CSLCs generated small lesions (5/6 mice) when injected at a dilution of 1 × 10 5 cells, which was confirmed by MRI ( Fig. 6A and B ). After MRI confirmed that xenografts had been formed, the mouse brain was removed ( Fig. 6C ). FIG. 6. Craniopharyngioma stem cell–like cells (CSLCs) can induce tumor initiation in human–mouse xenografts. A and B: MRIs of brain xenografts ( red arrows ) derived from CSLCs in the NOD/SCID mice. C and D: Brain xenografts derived from the