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Joseph G. Chusid, Lenore M. Kopeloff and Nicholas Kopeloff

A pplication of alumina cream by disc or injection into a cerebral hemisphere is an effective method for the production of chronic experimental epilepsy in monkeys. 7 The present study was undertaken to determine the comparative effectiveness of alumina cream injected into the cerebrospinal fluid of the cisterna magna. METHOD Alumina cream prepared in the laboratory was centrifuged and the sediment was injected into the cisterna magna of 5 young healthy Macaca mulatto , (3.4–4.4 kg.). Approximately 0.2 to 0.5 ml. of cisternal cerebrospinal fluid was

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John L. Fox

experiments demonstrated the comparative effectiveness of THAM, mannitol and urea on intracranial hypertension in dogs undergoing apneic diffusion of oxgenation as described above. 163–165 These drugs were given at a rate of 1 cc./kg./min. THAM, 0.3 molar (isomolar with blood), allowed no change in cerebrospinal-fluid pressure. Manitol, 0.6 molar, urea, 5.8 molar (usual hypertonic 30 per cent solution in invert sugar), and THAM, 0.6 molar, titrated to a pH of 7.4 with hydrochloric acid, allowed a rise of cerebrospinal-fluid pressure to about half that of the controls. Urea

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Mitchell R. Smigiel Jr. and Thoralf M. Sundt Jr.

✓The comparative effectiveness of isoproterenol (Isuprel), phentolamine (Regitine), and phenoxybenzamine (Dibenzyline) in modifying basilar arterial spasm induced by the topical application of arterial blood was studied in cats. None of these agents was effective in inhibiting initial peak constriction. Each reduced the duration of the vasospasm. The results indicate that both alpha-blockade and beta-stimulation can alter the course of blood-induced cerebral vasospasm.

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prostaglandin F 2 in human cerebral vasospasm Emanuele La Torre Carlo Patrono Aldo Fortuna Daniela Grossi-Belloni September 1974 41 3 293 299 10.3171/jns.1974.41.3.0293 Comparative effectiveness of alpha-blockade and beta-stimulation in modifying experimental basilar arterial spasm Mitchell R. Smigiel Jr. Thoralf M. Sundt Jr. September 1974 41 3 300 305 10.3171/jns.1974.41.3.0300 Anterior interosseous nerve syndrome Peter A. Lake September 1974 41 3 306 309 10.3171/jns.1974.41.3.0306 Cerebral blood flow

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Thoralf M. Sundt Jr.

, in Hitchcock E, Laitinen L, Vaernet K (eds): Psychosurgery. Springfield, Ill, Charles C Thomas, 1972, pp 5–21 6. Smigiel MR Jr , Sundt TM Jr : The comparative effectiveness of alpha-blockade and beta-stimulation in modifying experimental basilar arterial spasm. J Neurosurg 41 : 300 – 305 , 1974 Smigiel MR Jr, Sundt TM Jr: The comparative effectiveness of alpha-blockade and beta-stimulation in modifying experimental basilar arterial spasm. J Neurosurg 41: 300–305, 1974 7. Sundt TM

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Edward J. Kosnik and William E. Hunt

. Am J Med 23: 197–204, 1957 22. Smigiel MR Jr , Sundt TM Jr : Comparative effectiveness of alpha-blockade and betastimulation in modifying experimental basilar arterial spasm. J Neurosurg 41 : 300 – 305 , 1974 Smigiel MR Jr, Sundt TM Jr: Comparative effectiveness of alpha-blockade and betastimulation in modifying experimental basilar arterial spasm. J Neurosurg 41: 300–305, 1974 23. Symon L : Personal communication , October 11 , 1975 Symon L: Personal communication, October 11, 1975

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Jack M. Fein

prolonged hypoxia and ischemia. Arch Neurol 29 : 400 – 407 , 1973 Siesjö BK, Ljunggren B: Cerebral energy reserves after prolonged hypoxia and ischemia. Arch Neurol 29: 400–407, 1973 47. Smiegiel MR Jr , Sundt TM Jr : Comparative effectiveness of alpha-blockade and betastimulation in modifying experimental basilar arterial spasm. J Neurosurg 41 : 300 – 305 , 1974 Smiegiel MR Jr, Sundt TM Jr: Comparative effectiveness of alpha-blockade and betastimulation in modifying experimental basilar arterial spasm. J

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Richard P. White, Shang-Po Huang, A. Ainsworth Hagen and James T. Robertson

89 : 124 – 126 , 1975 Peterson EW, Leblanc R, Searle R, et al: Some considerations on cerebral vasospasm. Am Heart J 89: 124–126, 1975 21. Saito I , Ueda Y , Sano K : Significance of vasospasm in the treatment of ruptured intracranial aneurysms. J Neurosurg 47 : 412 – 429 , 1977 Saito I, Ueda Y, Sano K: Significance of vasospasm in the treatment of ruptured intracranial aneurysms. J Neurosurg 47: 412–429, 1977 22. Smigiel MR Jr , Sundt TM Jr : Comparative effectiveness of alpha

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Anna Levati, Maria L. Farina, Giuseppe Vecchi, Marina Rossanda and Marialuisa B. Marrubini

I n common with other researchers, 1, 2, 4, 8 we attribute great importance to determining the prognosis of severely head-injured patients. Several prognostic factors have been identified previously, and their comparative effectiveness in predicting outcome has been evaluated. In the series of patients presented here, the factors of greater prognostic significance have been studied as a contribution to the common goal of identifying methods for the stratification of cases into homogeneous classes of injury severity. We believe that this classification should

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Elizabeth A. M. Frost

, pp 660 – 663 Sklar FH, Beyer CW Jr, Ramanathan M, et al: The effects of furosemide on CSF dynamics in patients with pseudotumor cerebri, in Shulman K, Marmarou A, Miller JD, et al (eds): Intracranial Pressure IV. Berlin/Heidelberg/New York: Springer-Verlag, 1980, pp 660–663 93. Smigiel MR Jr , Sundt TM Jr : Comparative effectiveness of alpha-blockade and beta-stimulation in modifying experimental basilar arterial spasm. J Neurosurg 41 : 300 – 305 , 1974 Smigiel MR Jr, Sundt TM Jr: Comparative effectiveness of