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Eiichi Tani, Shogo Yamagata, Yukio Maeda and Yuko Ito

Pharmacol 36: 549–560, 1969 19. Goldberg ND : Cyclic nucleotides and cell function , in Weissman G , Claiborne R (eds): Cell Membranes: Biochemistry, Cell Biology, and Pathology. New York : HP Publishing , 1975 , pp 185 – 201 Goldberg ND: Cyclic nucleotides and cell function, in Weissman G, Claiborne R (eds): Cell Membranes: Biochemistry, Cell Biology, and Pathology. New York: HP Publishing, 1975, pp 185–201 20. Goldberg ND , O'Dea RF , Haddox MK : Cyclic GMP. Adv Cyclic

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Robert D. Harris, Edward L. Seljeskog, Kenneth J. Murray, Shelley N. Chou, William P. Cunningham and Steven D. Douglas

culture. Neurol Med Chir (Tokyo) 12 : 52 – 63 , 1972 Teraoka A: Morphological and functional properties of pituitary adenomas in culture. Neurol Med Chir (Tokyo) 12: 52–63, 1972 10. Vesely P , Boyde A : The significance of SEM evaluation of the cell surface for tumor cell biology , in Scanning Electron Microscopy/1973 Part III. Chicago : IIT Research Institute , 1973 , pp 689 – 696 Vesely P, Boyde A: The significance of SEM evaluation of the cell surface for tumor cell biology, in Scanning Electron

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the investigation of spinal cord injury , in Cowan WM (ed): Approaches to the Cell Biology of Neurons. Bethesda, Md : Society for Neuroscience , Vol 2 , 1977 , p 961 (Abstract) Boggan JE, de la Torre J, Mullan S: A rat model for the investigation of spinal cord injury, in Cowan WM (ed): Approaches to the Cell Biology of Neurons. Bethesda, Md: Society for Neuroscience, Vol 2, 1977, p 961 (Abstract) 2. Boggan JE , de la Torre J , Mullan S : Spinal cord injury in the rat: A new model. Presented at the

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problems. It is a bit staggering to realize that at least 80% of the cell biology taught in undergraduate school today was either unrecognized or merely theoretical 20 years ago. Within our own discipline of neurosurgery, major advances are occurring each decade that enhance our ability to understand diseases of the nervous system, to diagnose and localize disease processes, and to manage more effectively many of our elusive disease targets. Probably the most concise and comprehensive program in continuing medical education in neurosurgery, appropriate for practicing

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Traditions, Transition, and the Torch

The 1981 AANS presidential address

Robert B. King

quantitative methods in cellular and subcellular chemistry, anatomy, physiology, immunology, and other forms of cell biology. These we must harness. But the skills which are required to use these resources to unfold new knowledge and then to enfold it into medicine will be harnessed only if trained minds pursue disciplined careers dedicated to that purpose. A continuing supply of highly motivated, well trained investigators who teach, treat patients, and conduct research is essential to that end. More of those who conduct research must be physician-investigators, who can

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Jerald J. Bernstein and David Pagnanelli

, Mytilineoau C , Yahr MD , et al : Neurological aspects of neurofibromatosis , in Riccardi VM , Mulvihill JJ (eds): Neurofibromatosis (von Recklinghausen Disease). Genetics, Cell Biology, and Biochemistry. Advances in Neurology , Vol 29 . New York : Raven Press , 1981 , pp 11 – 21 Rubenstein AE, Mytilineoau C, Yahr MD, et al: Neurological aspects of neurofibromatosis, in Riccardi VM, Mulvihill JJ (eds): Neurofibromatosis (von Recklinghausen Disease). Genetics, Cell Biology, and Biochemistry. Advances in Neurology, Vol 29

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Harvey J. Sagar, Edward B. Ilgren and Christopher B. T. Adams

, 1966 (Ita) Volpi U: [Melanoblastoma of the choroid in Ota's syndrome.] Ann Ottal 92: 219–227, 1966 (Ita) 28. Weston JA : The regulation of normal and abnormal neural crest cell development , in Riccardi VM , Mulvihill JJ (eds): Neurofibromatosis (von Recklinghausen Disease). Genetics, Cell Biology, and Biochemistry. Advances in Neurology , Vol 29 . New York : Raven Press , 1981 , pp 77 – 95 (see Table 1) Weston JA: The regulation of normal and abnormal neural crest cell development, in Riccardi VM

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Barry J. Leaney, Peter W. Rowe and Geoffrey L. Klug

L : La mélanose neurocutanée diffuse hérédofamiliale. Bull Acad R Med Belg 13 : 397 – 427 , 1948 Van Bogaert L: La mélanose neurocutanée diffuse hérédofamiliale. Bull Acad R Med Belg 13: 397–427, 1948 27. Weston JA : The regulation of normal and abnormal neural crest cell development , in Riccardi VM , Mulvihill JJ (eds): Neurofibromatosis (Von Recklinghausen Disease). Genetics, Cell Biology, and Biochemistry. Advances in Neurology , Vol 29 . New York : Raven Press , 1981 , pp 77 – 96

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Erik-Olof Backlund, Per-Ola Granberg, Bertil Hamberger, Evert Knutsson, Anders Mårtensson, Göran Sedvall, Åke Seiger and Lars Olson

: Phenotypic plasticity of pheochromocytoma and normal adrenal medullary cells , in Eränkö O , Soinila S , Päivärinta H , et al (eds): Histochemistry and Cell Biology of Autonomic Neuron, SIF Cells, and Paraneurons. New York : Raven Press , 1980 , pp 61 – 68 Tischler AA, Greene LA: Phenotypic plasticity of pheochromocytoma and normal adrenal medullary cells, in Eränkö O, Soinila S, Päivärinta H, et al (eds): Histochemistry and Cell Biology of Autonomic Neuron, SIF Cells, and Paraneurons. New York: Raven Press, 1980, pp 61

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David W. Kimmel, Joan R. Shapiro and William R. Shapiro

LI is high. 41 They then enter a plateau phase as the cell layer reaches confluency. At this time, the cell layer is removed with trypsin and divided into two parts and replated. Each splitting is termed a passage. Monolayer culture can provide a large number of cells and allow isolation of small clones of cells from the larger cell population. 92 Cloning allows the investigator to separate tumor cells from any contaminating normal glial cells and to isolate subpopulations of tumor cells. This technique can be applied to quantitative studies on cell biology