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Ulrich Batzdorf and Nathan Malamud

neoplastic cells being predominantly fibrillary astrocytes that produced a network of glial fibers. The over-all diagnosis was considered to be astrocytoma, showing varying degrees of anaplasia. Fig. 4c. Case 4 . Structure of anaplastic astrocytoma of left temporal region. Hematoxylin and eosin, ×128. Fig. 4d. Case 4 . Fibrillary astrocytoma of left thalamic region. Phosphotungstic acid hematoxylin, ×128. Despite the occasional local infiltration of the leptomeninges, there was no evidence of connection between the several tumors. Case

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Labe C. Scheinberg, Kunihiko Suzuki, Fredric Edelman and Leo M. Davidoff

worth some consideration as an adjunct to current methods of treatment. Summary A series of experiments with an inbred strain of mice has demonstrated that intradermal immunization with emulsions of glioma and adjuvant before intracerebral implantation of the tumor inhibits growth of tumor. References 1. Battista , A. F. , Bloom , W. , Loffman , M. , and Feigin , I. Autotransplantation of anaplastic astrocytoma into the subcutaneous tissue of man. Neurology , 1961 , 11 : 977 – 981

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W. Bryan Jennett, D. Gordon McDowall and J. Barker

-old woman was admitted to the hospital after 5 weeks of headache and vomiting. She had had a major epileptic fit during the puerperium 4 years earlier, and for 2 years had been slowing down mentally. She had marked papilledema; the only neurological sign was facial weakness. Angiography revealed a large frontal tumor. At operation this proved to be an extensive infiltrating glioma, reported histologically to be an anaplastic astrocytoma. Method Each case was premedicated with 0.6 mg atropine. Anesthesia was induced with a sleep dose of thiopentone and, after the

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L. J. Rubinstein

vertebral marrow. H. & E., × 63. The pelvic and pancreatic lymph nodes and the large retroperitoneal mass were largely replaced by secondary malignant astrocytoma which displayed the same anaplastic features as the primary site and included a number of large multinucleated giant cells ( Fig. 7 ). In the retroperitoneal mass and pancreatic lymph node, several veins were permeated by tumor ( Fig. 8 ). Fig. 7. Metastatic anaplastic astrocytoma in paravertebral retroperitoneal mass. Note similarity to Fig. 5.H. &E., × 200. Fig. 8. Metastasis in

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Edgar A. Bering Jr., Charles B. Wilson and Horace A. Norrell Jr.

. Surg. , 1963, 157: 394–399. 2. Bakay , L. Morphological and chemical studies in cerebral edema: triethyl tin-induced edema. J. neurol. Sci. , 1965 , 2 : 52 – 67 . Bakay , L. Morphological and chemical studies in cerebral edema: triethyl tin-induced edema. J. neurol. Sci. , 1965, 2: 52–67. 3. Battista , A. F. , Bloom , W. , Loffman , M. , and Feigin , I. Autotransplantation of anaplastic astrocytoma into the subcutaneous tissue of man. Neurology, Minneap. , 1961 , 11 : 977 – 981

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M. El-Batata

the fluid removed from the fourth ventricle. The tumor cells have very scanty cytoplasm, and their nuclei are large with fine primitive chromatin. Ventricular CSF, ×1010. Case 7 (61732) A 63-year-old woman was admitted with a 1-year history of quadriparesis and progressive deterioration of intellect and memory. There was evidence of bilateral frontal lobe and basal ganglia disturbances thought likely due to a glioma involving the corpus callosum. Biopsy proved the presence of an anaplastic astrocytoma of the corpus callosum. Fluid obtained from the

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Donald R. Smith, John M. Hardman and Kenneth M. Earle

least 50 acceptable cases of primary neuroectodermal tumors of the central nervous system with extracranial metastases. These include all types of glial neoplasms and medulloblastomas. The case reported by Rubinstein 30 is most remarkable, as this patient is the only reported case of a glioma which metastasized outside the neuraxis prior to surgical intervention. His patient had an anaplastic astrocytoma with metastases to the vertebral bone marrow and abdominal lymph nodes. The primary tumor had invaded the sagittal sinus, and this was presumed to be the pathway

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Histochemistry of hydrolytic enzymes in cerebral tumors

The relationship between the different cytotypes and cell regression

Davide Schiffer

regressive or catabolic events, and cell differentiation. Acid phosphatase is confined to pericytial and scattered parenchymal cells in fibrillary astrocytoma, while it is more abundant in protoplasmatic and anaplastic astrocytoma, and reaches its highest intensity in glioblastoma. Perivascular and phagocytosing cells, perinecrotic palisadings, and most tumor cells from anisomorphic areas show strong positive reactions. Malignant cerebral tumors, such as medulloblastomas, and isomorphic areas of glioblastomas are poorly endowed with acid phosphatase, while very atypical

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Philippe Benda, Kuniyuki Someda, Janette Messer and William H. Sweet

-100, looked like epithelial cells, and, when injected into rats in the same dose of 10 6 cells, did not grow as a tumor. (Dr. Harvey Shein, who has maintained these cell cultures, has subsequently shown that Clone 3 cells in a large inoculum of 10–15 × 10 6 cells do give rise to rapidly growing tumors histologically similar to our Clone 2A. Hence, they are likely to be anaplastic astrocytomas even though we found no S-100 in them.) Although the presence of S-100 protein is sufficient to establish the neural character of a tumor cell, a low value in tumor cells

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Lawrence F. Marshall, Hume Adams, David Doyle and David I. Graham

. Meningioma. Left: Occasionally there are numerous cell whorls within the smear. Toluidine blue, X 300. Right: More frequently, there are sheets of cells with a distinctive arachnoidal appearance and only occasional cell whorls. Toluidine blue, X 300. Incorrect Diagnosis There were 11 cases in which the wrong diagnosis was made on the smears ( Table 2 ), but in seven of these, the error was no more than failure to classify a malignant tumor correctly. In five cases, anaplastic carcinoma was not correctly distinguished from anaplastic astrocytoma, the