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Raymond Sawaya, Mario Zuccarello and Robert Highsmith

assistance of Mrs. Pat Short. References 1. Ades EW , Hinson A , Chapuis-Cellier C , et al : Modulation of the immune response by plasma protease inhibitors. I. Alpha 2 -macroglobulin and alpha 1 -antitrypsin inhibit natural killing and antibody-dependent cell-mediated cytotoxicity. Scand J Immunol 15 : 109 – 113 , 1982 Ades EW, Hinson A, Chapuis-Cellier C, et al: Modulation of the immune response by plasma protease inhibitors. I. Alpha 2 -macroglobulin and alpha 1 -antitrypsin inhibit natural killing and antibody

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-hemorrhage” canine model. J Neurosurg 58: 11–17, 1983 9. Wellum GR , Irvine TW , Zervas NT : Dose responses of cerebral arteries of the dog, rabbit, and man to human hemoglobin in vitro . J Neurosurg 53 : 486 – 490 , 1980 Wellum GR, Irvine TW, Zervas NT: Dose responses of cerebral arteries of the dog, rabbit, and man to human hemoglobin in vitro . J Neurosurg 53: 486–490, 1980 10. White RP : Comparison of the inhibitory effects of antithrombin III, alpha 2-macroglobulin, and thrombin in human basilar arteries

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Geir Olav Hjortland, Solveig Suzanne Garman-Vik, Siri Juell, Øyvind Edon Olsen, Henry Hirschberg, Øystein Fodstad and Olav Engebraaten

: Pathology and Genetics of Tumours of the Nervous System. Lyon : IARC Press , 2000 Kleihues P, Cavenee WK: Pathology and Genetics of Tumours of the Nervous System. Lyon: IARC Press, 2000 20. Kounnas MZ , Morris RE , Thompson MR , et al : The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J Biol Chem 267 : 12420 – 12423 , 1992 Kounnas MZ, Morris RE, Thompson MR, et al: The alpha 2-macroglobulin receptor/low density lipoprotein

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Atlantoaxial instability in Dyggve-Melchior-Clausen syndrome

Case report and review of the literature

Frank Kandziora, Luitgard Neumann, Klaus John Schnake, Cyrus Khodadadyan-Klostermann, Stefan Rehart, Norbert P. Haas and Thomas Mittlmeier

. Pascual-Catroviejo I , Casas C , Rodriguez Costa T : [A case of Dyggve-Melchior-Clausen's syndrome.] An Esp Pediatr 9 : 91 – 96 , 1976 (Span) Pascual-Catroviejo I, Casas C, Rodriguez Costa T: [A case of Dyggve-Melchior-Clausen's syndrome.] An Esp Pediatr 9: 91–96, 1976 (Span) 35. Rastogi SC , Dyggve HV , Melchior JC , et al : Abnormal serum alpha 2-macroglobulin in Dyggve-Melchior-Clausen syndrome. J Clin Chem Clin Biochem 18 : 67 – 68 , 1980 Rastogi SC, Dyggve HV, Melchior JC, et

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Yushi Ueno, Masaaki Yamamoto, Israel Vlodavsky, Iris Pecker, Kohichi Ohshima and Takeo Fukushima

, Verheijen JH , de Bart AC , Weidle UH , Ruiter DJ , van Muijen GN : Decreased expression of both the low-density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor and its receptor-associated protein in late stages of cutaneous melanocytic tumor progression. Cancer Res 56 : 1432 – 1439 , 1996 de Vries TJ, Verheijen JH, de Bart AC, Weidle UH, Ruiter DJ, van Muijen GN: Decreased expression of both the low-density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor and its receptor

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A. Byron Young, Linda G. Ott, David Beard, Robert J. Dempsey, Phillip A. Tibbs and Craig J. McClain

protein concentrations after injury has been postulated by some investigators to be for the production of a protective or demarcating zone around areas of tissue destruction. For example, proteinases released from leukocytes and lysosomes released from destroyed cells are inhibited by proteinase inhibitors such as alpha-1-antitrypsin and alpha-2-macroglobulin. An increase in fibrinogen provides adequate substrate for formation of fibrin and blood coagulation at the wound site. Moreover, certain of these proteins may play a regulatory role in the acute-phase response

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Ichiro Yuki, Daniel Lee, Yuichi Murayama, Alexander Chiang, Harry V. Vinters, Ichiro Nishimura, Chiachien J. Wang, Akira Ishii, Benjamin M. Wu and Fernando Viñuela

2.02 0.027 X56677 Human MyoD mRNA LRP1 2.01 0.015 NM_002332 H. sapiens low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) (LRP1), mRNA SCGB3A1 2.01 0.038 NM_052863 H. sapiens secretoglobin, family 3A, member 1 (SCGB3A1), mRNA FLJ30277 2.00 0.041 NM_153008 H. sapiens hypothetical protein FLJ30277 (FLJ30277), mRNA RNPEP 2.00 0.007 NM_020216 H. sapiens arginyl aminopeptidase (aminopeptidase B) (RNPEP), mRNA SCRIB 1.99 0.037 NM_015356 H. sapiens scribble (SCRIB), transcript

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Oliver D. Mrowczynski, Russell A. Payne, Alexandre J. Bourcier, Christine Y. Mau, Becky Slagle-Webb, Ganesh Shenoy, Achuthamangalam B. Madhankumar, Stephan B. Abramson, Darren Wolfe, Kimberly S. Harbaugh, Elias B. Rizk and James R. Connor

.1093/neuonc/nos287 21 Kornmann M , Kleeff J , Debinski W , Korc M : Pancreatic cancer cells express interleukin-13 and -4 receptors, and their growth is inhibited by Pseudomonas exotoxin coupled to interleukin-13 and -4 . Anticancer Res 19 ( 1A ): 125 – 131 , 1999 10226533 22 Kounnas MZ , Morris RE , Thompson MR , FitzGerald DJ , Strickland DK , Saelinger CB : The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A . J Biol Chem 267 : 12420 – 12423 , 1992 1618748