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Thomas B. Crotty, Bernd W. Scheithauer, William F. Young Jr., Dudley H. Davis, Edward G. Shaw, Gary M. Miller and Peter C. Burger

C raniopharyngiomas are uncommon tumors with distinctive histological features and a pronounced tendency to invade locally and to recur following therapy. 5, 14, 16 Two variants of craniopharyngioma, with differing clinical and morphological features, have been described. The adamantinomatous craniopharyngioma is composed of a complex mixture of adamantinoma-like epithelium, “wet” keratin, microcalcifications, necrotic debris, fibrosis, and micro- or macrocysts. In contrast, papillary craniopharyngiomas form papillae composed of mature squamous epithelium and

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Marc S. Arginteanu, Karin Hague, Robert Zimmerman, Mark J. Kupersmith, John H. Shaiu, John Schaeffer and Kalmon D. Post

craniopharyngioma. Typical palisading of epithelial cells around loose stellate reticulum and nodules of “wet” keratin were identified ( Fig. 4 ). Fig. 4. Photomicrograph of a tumor specimen displaying the characteristic nodular “wet” keratin, palisading nuclei, and stellate reticulum of an adamantinomatous craniopharyngioma. H & E, original magnification × 200. Discussion Craniopharyngiomas are histologically benign tumors that exhibit a spectrum of cytological patterns. The well-differentiated papillary subtype of craniopharyngioma is an indolent lesion

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Kazumichi Yamada, Masaki Miura, Haruhiko Miyayama, Naohiko Furuyoshi, Jun Matsumoto and Yukitaka Ushio

, George DP , Fannin LA : Juvenile xanthogranuloma of the iris in an adult. Arch Ophthalmol 116 : 377 – 379 , 1998 Parmley VC, George DP, Fannin LA: Juvenile xanthogranuloma of the iris in an adult. Arch Ophthalmol 116: 377–379, 1998 23. Paulus W , Honegger J , Keyvani K , et al : Xanthogranuloma of the sellar region: a clinicopathological entity different from adamantinomatous craniopharyngioma. Acta Neuropathol 97 : 377 – 382 , 1999 Paulus W, Honegger J, Keyvani K, et al: Xanthogranuloma

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Dae Kyu Lee, Hee-Won Jung, Dong Gyu Kim, Sun Ha Paek, Ho-Shin Gwak and Gheeyoung Choe

ectopic recurrence in the cranial cavity have been reported. 1, 5, 6, 8, 10, 12, 14 The authors present a case of postoperative spinal seeding of a craniopharyngioma of the papillary histological type, which is usually encountered in adults as a solid noncalcified mass, often within the third ventricle, in contrast with the adamantinomatous type. 2 No spinal seeding of either papillary or adamantinomatous craniopharyngiomas has been reported previously. Case Report First Admission History This 26-year-old man was admitted with headache and decreased

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Florence Lefranc, Catherine Chevalier, Mathieu Vinchon, Patrick Dhellemmes, Max-Peter Schüring, Herbert Kaltner, Jacques Brotchi, Marie-Magdeleine Ruchoux, Hans-Joachim Gabius, Isabelle Salmon and Robert Kiss

palisading columnar cells that resemble the ameloblasts of fetal tooth buds, may be of embryonic origin. 35 This childhood type is referred to as the adamantinomatous variant and closely resembles adamantinomas of the jaw. 8 This is by far the most common histopathological type of craniopharyngioma. Misplaced odontogenic epithelium is thought to be a reasonable source of childhood-type (adamantinomatous) craniopharyngiomas; the adult type consists mainly of mature stratified squamous cells and may be of metaplastic origin. Histologically, this tumor displays papillary

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Shlomit Rienstein, Eric F. Adams, David Pilzer, Ayala Aviram Goldring, Boleslaw Goldman and Eitan Friedman

, 2002 Ramaswamy S, Golub TR: DNA microarrays in clinical oncology. J Clin Oncol 20: 1932–1941, 2002 11. Sarubi JC , Bei H , Adams EF , et al : Clonal composition of human adamantinomatous craniopharyngiomas and somatic mutation analyses of the patched (PTCH), Gsα and Gi2α genes. Neurosci Lett 310 : 5 – 8 , 2001 Sarubi JC, Bei H, Adams EF, et al: Clonal composition of human adamantinomatous craniopharyngiomas and somatic mutation analyses of the patched (PTCH), Gsα and Gi2α genes. Neurosci Lett 310: 5–8, 2001

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Oiwa Rosario Sanchez-Pernaute Judith Harvey-White Krys S. Bankiewicz January 2003 98 1 136 144 10.3171/jns.2003.98.1.0136 Characterization of the levels of expression of retinoic acid receptors, galectin-3, macrophage migration inhibiting factor, and p53 in 51 adamantinomatous craniopharyngiomas Florence Lefranc Catherine Chevalier Mathieu Vinchon Patrick Dhellemmes Max-Peter Schüring Herbert Kaltner Jacques Brotchi Marie-Magdeleine Ruchoux Hans-Joachim Gabius Isabelle Salmon

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Maisa Yoshimoto, Sílvia Regina Caminada de Toledo, Nasjla Saba da Silva, Jane Bayani, Ana Paula Antunes Pascalicchio Bertozzi, Joã Norberto Stavale, Sergio Cavalheiro, Joyce Anderson Duffles Andrade, Maria Zielenska and Jeremy A. Squire

yes yes yes SD, 5 normal 9 6, F AC partial no yes no DOI, 1 normal 10 † 4.7, F AC partial yes yes yes DP, 7 normal control 13.4, M normal hypophysial tissue NA NA NA NA NA normal * AC = adamantinomatous craniopharyngioma; DF = disease free; DOD = died of disease; DOI = died of infection; DP = disease progression; SD = stable disease. † Samples obtained at time of recurrence. Seven patients underwent partial tumor resection, two subtotal tumor resection, and

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preliminary report of a novel technique P. David Adelson Eugene A. Bonaroti Todd P. Thompson Minhduc Tran N. Ake Nystrom August 2004 101 2 78 84 10.3171/ped.2004.101.2.0078 Comparative genomic hybridization analysis of pediatric adamantinomatous craniopharyngiomas and a review of the literature Maisa Yoshimoto Sílvia Regina Caminada de Toledo Nasjla Saba da Silva Jane Bayani Ana Paula Antunes Pascalicchio Bertozzi Joã Norberto Stavale Sergio Cavalheiro Joyce Anderson Duffles Andrade Maria

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Adrian Caceres, Aaron J. Reitman and Tadanori Tomita

with adamantinomatous craniopharyngioma. One month later, the patient underwent resection of the mass. Intraoperatively, the tumor was located beneath the optic chiasm, infiltrating and involving the pituitary stalk. Calcifications were observed on the tumor capsule as well as a cyst containing dark, thick machine-oillike fluid. The right optic nerve was discolored with a yellow—green hue. Gross-total resection was achieved; however, the pituitary stalk had to be sectioned because it was blended into the tumor ( Fig. 2 ). Fig. 2. A: Enhanced axial