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Alec W. Gibson, Abdullah H. Feroze, Madeline E. Greil, Margaret E. McGrath, Sananthan Sivakanthan, Gabrielle A. White-Dzuro, John R. Williams, Christopher C. Young, and Christoph P. Hofstetter

this study (ViviGen, Johnson & Johnson) is composed of cryopreserved viable osteogenic cells with a corticocancellous scaffold in a demineralized bone matrix, and it may help improve fusion rates in procedures with historically high failure rates. Frozen cellular allograft can be thawed in 5 minutes for rapid intraoperative use while maintaining a 96% cell viability. Furthermore, the product used for this study is enriched with osteoblasts and osteocytes as opposed to undifferentiated mesenchymal stem cells, thus minimizing the differentiation of undesirable cell

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Spencer C. Darveau, Owen P. Leary, Elijah M. Persad-Paisley, Elias A. Shaaya, Adetokunbo A. Oyelese, Jared S. Fridley, Prakash Sampath, Joaquin Q. Camara-Quintana, Ziya L. Gokaslan, and Tianyi Niu

(Osteocel) OR (ViviGen) OR (map3) OR (VIA Graft) OR (Trinity)) AND ((spinal fusion) OR ((spine) AND (fusion)) OR ((spine) AND (arthrodesis))). Identified articles were included if they were available in the English language and contributed new patients who had undergone spinal fusion using CBMs ( Fig. 1 ). Level of evidence (I–V) was assessed for each article according to the GRADE (Grading of Recommendations Assessment, Development and Evaluation) working group and the AHRQ (Agency for Healthcare Research and Quality). 18–20 The US National Library of Medicine

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Ryan R. Diaz, Amey R. Savardekar, Jared R. Brougham, Danielle Terrell, and Anthony Sin

CBM Product Associated Companies Components Cell Count Cell Viability * ViviGen DePuy Synthes, LifeNet Health, Johnson & Johnson Lineage committed bone cells (MSCs removed), corticocancellous chips, & demineralized bone Not available 96% Trinity Evolution Orthofix, MTF Biologics Cancellous bone w/ viable OPCs & MSCs w/in the matrix & demineralized cortical bone component ≥250,000 cells/cm 3 (≥50,000 cells/cm 3 are MSCs &/or OPCs) Not available Trinity ELITE Orthofix, MTF Biologics Cancellous bone, demineralized