Search Results

You are looking at 1 - 10 of 1,128 items for :

  • "Parkinson disease" x
  • Refine by Access: all x
Clear All
Full access

Georgia Xiromerisiou, Efthimios Dardiotis, Vaïa Tsimourtou, Persa Maria Kountra, Konstantinos N. Paterakis, Eftychia Z. Kapsalaki, Kostas N. Fountas, and Georgios M. Hadjigeorgiou

that they have a higher prevalence of psychiatric disturbances. 3 , 17 The third locus for autosomal recessive juvenile parkinsonism was mapped also to chromosome 1p36, and the gene was identified as the oncogene DJ-1 (PARK7) . 6 The function of the DJ-1 protein is not entirely clear. The main hypothesis is that it acts as a sensor for oxidative stress, providing neuroprotection in situations of increased demand. 7 , 93 Parkinson disease causing DJ-1 mutations is rare and accounts for only ~ 1–2% of early-onset autosomal recessive PD cases. The phenotype

Restricted access

Philip C. Su, Ham-Min Tseng, Hon-Man Liu, Ruoh-Fang Yen, and Horng-Huei Liou

2. Alvarez L , Macias R , Guridi J , et al : Dorsal subthalamotomy for Parkinson's disease. Mov Disord 16 : 72 – 78 , 2001 Alvarez L, Macias R, Guridi J, et al: Dorsal subthalamotomy for Parkinson's disease. Mov Disord 16: 72–78, 2001 3. Aziz TZ , Peggs D , Agarwal E , et al : Subthalamic nucleotomy alleviates parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed primate. Br J Neurosurg 6 : 575 – 582 , 1992 Aziz TZ, Peggs D, Agarwal E, et al

Restricted access

Neurosurgical Forum: Letters to the Editor To The Editor Paolo Ferroli , M.D. Angelo Franzini , M.D. Carlo Marras , M.D. Giovanni Broggi , M.D. Istituto Nazionale Neurologico C. Besta Milan, Italy 641 643 Abstract Object. A blinded evaluation of the effects of subthalamic nucleus (STN) stimulation was performed in levodopa-intolerant patients with Parkinson disease (PD). These patients (Group I, seven patients) were moderately or severely disabled (Hoehn and

Restricted access

Sergio Canavero, Riccardo Paolotti, Vincenzo Bonicalzi, Giancarlo Castellano, Stefania Greco-Crasto, Laura Rizzo, Ottavio Davini, Francesco Zenga, and Paola Ragazzi

. Brain Res 44: 357–369, 1972 2. Canavero S , Bonicalzi V : Therapeutic extradural cortical stimulation for central and neuropathic pain: a review. Clin J Pain 18 : 48 – 55 , 2002 Canavero S, Bonicalzi V: Therapeutic extradural cortical stimulation for central and neuropathic pain: a review. Clin J Pain 18: 48–55, 2002 3. Canavero S , Paolotti R : Extradural motor cortex stimulation for advanced Parkinson's disease: case report. Mov Disord 15 : 169 – 171 , 2000 Canavero S, Paolotti R

Restricted access

Peter M. Intemann, Donna Masterman, Indu Subramanian, Antonio DeSalles, Eric Behnke, Robert Frysinger, and Jeff M. Bronstein

the patients in this study as well as Henrietta Salazar and Cynthia Cabatan-Awang, R.N., M.N. References 1. Alterman RL , Kelly PJ : Pallidotomy technique and results: the New York University experience. Neurosurg Clin North Am 9 : 337 – 343 , 1998 Alterman RL, Kelly PJ: Pallidotomy technique and results: the New York University experience. Neurosurg Clin North Am 9: 337–343, 1998 2. Anonymous : Sinemet CR for Parkinson's disease. Med Lett Drug Ther 33 : 92 – 93 , 1991 Anonymous: Sinemet

Restricted access

Ahmed Alkhani and Andres M. Lozano

: Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study. Ann Neurol 40 : 355 – 366 , 1996 Baron MS, Vitek JL, Bakay RAE, et al: Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study. Ann Neurol 40: 355–366, 1996 7. Bennett KMB , O'Sullivan JD , Peppard RF , et al : The effect of unilateral posteroventral pallidotomy on the kinematics of the reach to grasp movement. J Neurol Neurosurg Psychiatry 65 : 479 – 487

Full access

Cheerag D. Upadhyaya, Philip A. Starr, and Praveen V. Mummaneni

to DBS (left) , and postoperative image obtained after DBS at 24-month follow-up (right) . Case 2: Bilateral GPi DBS This patient was a 59-year-old man with PD and severe camptocormia. Parkinson disease was diagnosed based on the initial presenting symptoms of a severe stooped posture, decreased fine finger movements, and bilateral hand tremor. The patient's camptocormia only minimally responded to dopaminergic medications, and he would fall several times a day. He had begun wearing kneepads to prevent further injury from his frequent falls. He underwent

Full access

Arnar Astradsson, Oliver Cooper, Angel Vinuela, and Ole Isacson

within 48 hours of harvest. Striatal fluorodopa uptake was significantly increased in both the 1- and 4-donor transplantation groups, and robust survival of DA neurons was found at postmortem examination of 4 patients. Nevertheless, the study failed to meet its primary endpoint. There was no significant improvement in the motor component of the Unified Parkinson's Disease Rating Scale, although a treatment effect was observed in patients with milder disease. In addition, off-medication dyskinesias were observed in as many as 56% of the patients who received transplants

Restricted access

Oluwakemi Y. Fagbami and Anthony A. Donato

United Parkinson's Disease Rating Scale scores by more than 50% and reduces measures of dyskinesia by 75%, 4 making this therapy an important adjunct for patients with refractory disease or an intolerance to high doses of antiparkinsonian medications. Implantations of DBSs have now been performed in an estimated 35,000 patients with PD worldwide. 4 Case Report History and Examination This 74-year-old man with refractory PD of 14 years' duration and good motor response to deep brain stimulator implantation into the STN 14 months earlier presented with an

Restricted access

10.3171/jns.2005.102.2.0401 Neurosurgical Forum: Letters to the Editor To The Editor John T. Slevin , M.D. Greg A. Gerhardt , Ph.D. Charles D. Smith , M.D. Don M. Gash , Ph.D. Richard Kryscio , Ph.D. Byron Young , M.D. Morris K. Udall Parkinson Disease Research Center of Excellence University of Kentucky Lexington, Kentucky Department of Veterans Affairs Medical Center Lexington, Kentucky 401 401 Abstract Object. Glial cell