Search Results

You are looking at 1 - 10 of 371 items for :

Clear All
Restricted access

Andrew J. Molyneux and Stuart C. Coley

U ntil recently the only liquid embolic agent available for the treatment of brain and spinal cord AVMs has been cyanoacrylate tissue adhesive. This material has never been licensed for intravascular use and is not officially available in the United States. The Onyx liquid embolic system (Micro Therapeutics, Inc., Irvine, CA) consists of an ethylene vinyl alcohol copolymer dissolved in DMSO. When it comes in contact with water or blood, the material precipitates due to rapid diffusion of the DMSO solvent. It is the first liquid agent to be evaluated in

Restricted access

in dimethyl sulfoxide (Onyx liquid embolic system) Andrew J. Molyneux Stuart C. Coley October 2000 93 2 304 308 10.3171/spi.2000.93.2.0304 Split cord malformation with partial eventration of the diaphragm Anupam Jindal Somil Kansal Ashok Kumar Mahapatra October 2000 93 2 309 311 10.3171/spi.2000.93.2.0309 Eosinophilic granuloma of the spine: early spontaneous disappearance of tumor detected on magnetic resonance imaging Mikio Kamimura Tetsuya Kinoshita Hidehiro Itoh Yohei Yuzawa Jun Takahashi

Restricted access

Michel E. Mawad, Saruhan Cekirge, Elisa Ciceri and Isil Saatci

procedure for the treatment of large, giant, or otherwise complex and wide-necked aneurysms. The method consists of combining placement of a balloon-expandable stent at the neck of the aneurysm and obliteration of the fundus with liquid polymer (Onyx; MicroTherapeutics Corp., Irvine, CA). The polymer consists of ethyl vinyl alcohol mixed with DMSO as a solvent. Clinical Material and Methods We treated 11 patients (10 female and one male), who ranged in age from 9 to 81 years. All 11 patients were symptomatic; the five with large or giant cavernous aneurysms

Restricted access

the use of the drug. In theory, because papaverine has not been approved for topical use, this regulation placed all neurosurgeons who regularly use topical papaverine during vascular surgery in a legally conflicted situation. Fortunately, because of the common sense of law enforcement officials, this has not yet caused any problems. The same legal issue presents an obstacle to the use of intratumor chemotherapy (for example, bleomycin use in craniopharyngioma and Onyx use in embolization) and those applications that are currently used with written patient consent

Restricted access

Jun-Ichiro Hamada, Yutaka Kai, Motohiro Morioka, Kiyoshi Kazekawa, Yasuji Ishimaru, Hiroo Iwata and Yukitaka Ushio

developed the original formulation of Onyx (Onyx Liquid Embolic System; Micro Therapeutics, Inc., Irvine, CA). It was used extensively in Japan to treat cerebral AVMs and for tumor embolization. More recently, Onyx has been used in Europe, and it is currently being investigated as an embolic material in the United States for treatment of both cerebral AVMs and large and giant intracranial aneurysms. 11, 28 Onyx is a liquid, opaque embolic material that is easily injected through a microcatheter; its nonadhesive nature allows for a more controlled and longer delivery

Restricted access

Jun-Ichiro Hamada, Yutaka Kai, Motohiro Morioka, Kiyoshi Kazekawa, Yasuji Ishimaru, Hiroo Iwata and Yukitaka Ushio

embolic agents such as PVA, acrylics, and ethanol. More recently, Chaloupka, et al., 3 reevaluated the microvascular angiotoxicity of superselective infusions of DMSO by using very slow infusion rates. They found that slow priming infusions of small quantities of DMSO (0.5 ml injected over 30–120 seconds) did not produce angiographically evident vasospasms or sequelae in swine. Because additional studies demonstrated satisfactory tolerance in the swine model described by Murayama, et al., 11 a reformation of EVAL dissolved in DMSO has been developed (Onyx, formerly

Restricted access

Alessandra Alfieri, Raffaele Schettino, Angelo Taborelli, Maurizio Pontiggia, Paolo Reganati, Valerio Ballarini and Luigi Monolo

materials are currently used. In general they are radiopaque liquid polymers with embolic properties. Among them the most used are the cyanoacrylates. 5 More recently a new liquid embolic agent consisting of ethylene-vinyl-alcohol copolymer, dimethyl sulfoxide, and tantalum (ONYX) has been introduced for endovascular embolization. This is a promising new nonadhesive agent, which is particularly suitable for preoperative embolization of arteriovenous malformations. 13 We sought out a solidifying material, something already used and consolidated in clinical practice

Restricted access

Eric D. Akin, Eddie Perkins and Ian B. Ross

Ethiodol not only allow for good nidal injections but also, from a surgical perspective, result in embolized vessels that are reasonably pliable and easy to cut through. Embolization with pure NBCA is rarely performed today because it results in brittle vessels that may be difficult to dissect and cut. Even with pure NBCA, however, there appear to be advantages to preoperative embolization. 6 Onyx, an ethylene vinyl alcohol copolymer that is suspended in DMSO, is available for the embolization of AVMs and aneurysms in several countries outside North America and is

Restricted access

Christopher L. Taylor, Kim Dutton, George Rappard, G. Lee Pride, Robert Replogle, Phillip D. Purdy, Jonathan White, Cole Giller, Thomas A. Kopitnik Jr. and Duke S. Samson

radiosurgery. Embolization was performed during 324 procedures (95.6%). In 15 procedures (4.4%) no embolization was performed because the patient failed selective amobarbital testing, appropriate selective catheterization was not achieved, or a complication occurred during catheterization and before embolization. Polyvinyl alcohol particles (Boston Scientific Target, Fremont, CA) were used in 260 procedures (80.2%), NBCA glue (Trufill; Cordis Neurovascular, Inc., Miami Lakes, FL) in 43 (13.3%), detachable coils in 30 (9.3%), and Onyx liquid polymer (Microtherapeutics

Restricted access

Stéphane Fuentes, Olivier Levrier, Philippe Metellus, Henry Dufour, Jean Marc Fuentes and François Grisoli

aneurysm sac. Fig. 2. Left: Three-dimensional right ICA angiogram (anterior projection) obtained after the aneurysm was embolized with coils and Onyx liquid material. Right: Postoperative axial MR image. The patient was discharged home 7 days later. On examination 6 months later, her visual acuity was 10/10 and her visual field was normal. An MR image confirmed complete decompression of the lesion ( Fig. 2 right ). Fusiform intracranial aneurysms in the region of the ACoA are rare. They represent a major neurosurgical and neurovascular challenge