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Chiman Jeon, Kyung Rae Cho, Jung Won Choi, Doo-Sik Kong, Ho Jun Seol, Do-Hyun Nam, and Jung-Il Lee

-term radiation-related complications have also been reported following RT. 11 , 15–17 As an alternative to RT, stereotactic radiosurgery (SRS) has emerged as a minimally invasive adjuvant or primary treatment for CNs. The effectiveness of Gamma Knife radiosurgery (GKRS) for CNs has been reported, with a high rate of tumor control and a low complication rate. 12 , 18–23 To our knowledge, a limited number of studies have evaluated the usefulness of SRS as a primary treatment for CNs. 8 , 12 , 24 , 25 The goal of this study was to report a single-center experience

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Mark D. Meadowcroft, Timothy K. Cooper, Sebastian Rupprecht, Thaddeus C. Wright, Elizabeth E. Neely, Michele Ferenci, Weimin Kang, Qing X. Yang, Robert E. Harbaugh, James R. Connor, and James McInerney

which are invasive treatments with varying degrees of risk and effectiveness. Given these risks, asymptomatic aneurysms may not be appropriately treated prophylactically, and as a result, patients are not typically screened for intracranial aneurysms. Presently, there are no noninvasive treatment options for cerebral aneurysms. Current minimally invasive treatment for other cerebral vascular abnormalities, such as arteriovenous malformations (AVMs), include the use of Gamma Knife radiosurgery (GKRS), resulting in hemodynamic and histopathological alterations, with

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Robert M. Starke, Colin J. Przybylowski, Mukherjee Sugoto, Francis Fezeu, Ahmed J. Awad, Dale Ding, James H. Nguyen, and Jason P. Sheehan

neuromas, and brain metastases as well. 12 , 18 , 26 In the present study, we retrospectively reviewed data of patients harboring large WHO Grade I skull base meningiomas (volume > 8 cm 3 ) who were treated with single-session Gamma Knife radiosurgery (GKRS) to identify prognostic factors associated with successful and adverse radiological and clinical outcomes. Methods Patient Population This is a retrospective analysis of a prospectively maintained database approved by the University of Virginia institutional review board. The database was assessed from 1989

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Alex M. Landolt and Nicoletta Lomax

levels. It is thought that no other therapeutic option can be offered that will not diminish fertility. Clinical Material and Methods Gamma knife radiosurgery was performed in 20 patients (five men and 15 women, ranging in age from 24–74 years) harboring prolactinomas in whom hyperprolactinemia persisted after surgery and/or treatment with dopaminergic drugs. All the patients but one experienced disturbances of sexual function: amenorrhea, infertility, and loss of potency. The exception was a 74-year-old woman who suffered from trigeminal neuralgia caused by an

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Wen-Yuh Chung, David Hung-Chi Pan, Cheng-Ying Shiau, Wan-Yuo Guo, and Ling-Wei Wang

in coronal T 1 -weighted MR images (A and B). Before GKS, hydrocephalus and poor consciousness was corrected by placement of a ventriculoperitoneal shunt, followed by stereotactic aspiration of the large cyst (arrow) and Ommaya reservoir implantation. C and D: Images revealing that the tumor volume has decreased to 6 cm 3 , which is suitable for GKS. E and F: Images revealing the tumor response to a 12-Gy margin dose. The tumor volume shrank to 0.7 cm 3 6 months after GKS. Gamma Knife Radiosurgery Gamma knife radiosurgery was used as the initial

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Maria Luisa Gandía-González, M. Elena Kusak, Nuria Martínez Moreno, Jorge Gutiérrez Sárraga, Germán Rey, and Roberto Martínez Álvarez

acknowledged that, according to recent publications, surgery carries a mortality rate of about 4%. 22 , 26 To avoid the significant morbidity associated with excision, conventional radiotherapy has been used increasingly in the treatment of JTPs. 2 , 28 However, this treatment has side effects. 23 Because of its efficacy and precision, Gamma Knife radiosurgery (GKRS) has been used successfully to treat JTPs in many centers, 4 , 5 , 7–9 , 15 , 19 , 20 , 24 , 26 , 29 minimizing the radiation adverse effects. Gamma Knife radiosurgery was performed in 75 patients with

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Atsushi Shimizu, Koji Yamaguchi, Yoshikazu Okada, Takayuki Funatsu, Tatsuya Ishikawa, Motohiro Hayashi, Noriko Tamura, Ayako Horiba, and Takakazu Kawamata

Gamma Knife radiosurgery (GKRS) is a safe and effective treatment modality for cerebral arteriovenous malformations (AVMs) that reduces the risk of bleeding, seizure, and some neurological deficits caused by stroke. 1–10 However, there is a risk of bleeding and radiation-induced perifocal edema and seizure before complete resolution of the nidus can be obtained with GKRS. 1 , 9 , 11–18 Bleeding secondary to GKRS is usually caused by a residual AVM or recanalization of the organized intraluminal thrombus and hemodynamic changes (e.g., thrombosis or narrowing

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Zjiwar H. A. Sadik, Suan Te Lie, Sieger Leenstra, and Patrick E. J. Hanssens

Gamma Knife radiosurgery (GKRS) has been increasingly used as a primary treatment for PCMs during the past decade, 20 , 24 , 26 , 27 , 36 , 44 , 51 , 60 especially for patients with small tumors (< 3 cm) or elderly patients who may not be able to tolerate surgery due to medical comorbidities. Based on our own experience, GKRS can achieve significant volumetric tumor decrease, resulting in decreased pressure on CNs and symptom improvement. In the present study, we present qualitative volumetric changes after primary GKRS for PCM and relate these to clinical symptoms

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Youlin Ge, Dong Liu, Zhiyuan Zhang, Yanhe Li, Yiguang Lin, Guokai Wang, Yongqing Zong, and Enhu Liu

radiation beyond the planning target volume reduces long-term radiation-related complications. Gamma Knife radiosurgery (GKRS) is now increasingly used for the treatment of intracranial meningiomas due to its precise positioning of intracranial lesions. This is a single-center outcome study of the midterm efficacy of GKRS in the treatment of benign intracranial meningiomas. Methods Patient Population This cohort was composed of 130 patients with intracranial WHO grade I meningiomas who underwent GKRS at the Second Hospital of Tianjin Medical University between May 2012

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Mihir Gupta, Varun Sagi, Aditya Mittal, Anudeep Yekula, Devan Hawkins, Justin Shimizu, Pate J. Duddleston, Kathleen Thomas, Steven J. Goetsch, John F. Alksne, David W. Hodgens, Kenneth Ott, Kenneth T. Shimizu, Christopher Duma, and Sharona Ben-Haim

T rigeminal neuralgia (TN) is a rare neuropathic facial pain disorder characterized by recurrent episodes of pain in the distribution of one or more trigeminal nerve divisions. 1 Pain associated with TN is considered among the most severe pain of neurological origin and has devastating impacts on daily life. 2 Although a variety of medical and surgical treatments for TN have been developed, maintaining long-term relief remains extremely challenging because of continued or recurrent pain after treatment in many patients. Gamma Knife radiosurgery (GKRS