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Mark D. Meadowcroft, Timothy K. Cooper, Sebastian Rupprecht, Thaddeus C. Wright, Elizabeth E. Neely, Michele Ferenci, Weimin Kang, Qing X. Yang, Robert E. Harbaugh, James R. Connor and James McInerney

which are invasive treatments with varying degrees of risk and effectiveness. Given these risks, asymptomatic aneurysms may not be appropriately treated prophylactically, and as a result, patients are not typically screened for intracranial aneurysms. Presently, there are no noninvasive treatment options for cerebral aneurysms. Current minimally invasive treatment for other cerebral vascular abnormalities, such as arteriovenous malformations (AVMs), include the use of Gamma Knife radiosurgery (GKRS), resulting in hemodynamic and histopathological alterations, with

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Robert M. Starke, Colin J. Przybylowski, Mukherjee Sugoto, Francis Fezeu, Ahmed J. Awad, Dale Ding, James H. Nguyen and Jason P. Sheehan

neuromas, and brain metastases as well. 12 , 18 , 26 In the present study, we retrospectively reviewed data of patients harboring large WHO Grade I skull base meningiomas (volume > 8 cm 3 ) who were treated with single-session Gamma Knife radiosurgery (GKRS) to identify prognostic factors associated with successful and adverse radiological and clinical outcomes. Methods Patient Population This is a retrospective analysis of a prospectively maintained database approved by the University of Virginia institutional review board. The database was assessed from 1989

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Alex M. Landolt and Nicoletta Lomax

levels. It is thought that no other therapeutic option can be offered that will not diminish fertility. Clinical Material and Methods Gamma knife radiosurgery was performed in 20 patients (five men and 15 women, ranging in age from 24–74 years) harboring prolactinomas in whom hyperprolactinemia persisted after surgery and/or treatment with dopaminergic drugs. All the patients but one experienced disturbances of sexual function: amenorrhea, infertility, and loss of potency. The exception was a 74-year-old woman who suffered from trigeminal neuralgia caused by an

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Wen-Yuh Chung, David Hung-Chi Pan, Cheng-Ying Shiau, Wan-Yuo Guo and Ling-Wei Wang

in coronal T 1 -weighted MR images (A and B). Before GKS, hydrocephalus and poor consciousness was corrected by placement of a ventriculoperitoneal shunt, followed by stereotactic aspiration of the large cyst (arrow) and Ommaya reservoir implantation. C and D: Images revealing that the tumor volume has decreased to 6 cm 3 , which is suitable for GKS. E and F: Images revealing the tumor response to a 12-Gy margin dose. The tumor volume shrank to 0.7 cm 3 6 months after GKS. Gamma Knife Radiosurgery Gamma knife radiosurgery was used as the initial

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Maria Luisa Gandía-González, M. Elena Kusak, Nuria Martínez Moreno, Jorge Gutiérrez Sárraga, Germán Rey and Roberto Martínez Álvarez

acknowledged that, according to recent publications, surgery carries a mortality rate of about 4%. 22 , 26 To avoid the significant morbidity associated with excision, conventional radiotherapy has been used increasingly in the treatment of JTPs. 2 , 28 However, this treatment has side effects. 23 Because of its efficacy and precision, Gamma Knife radiosurgery (GKRS) has been used successfully to treat JTPs in many centers, 4 , 5 , 7–9 , 15 , 19 , 20 , 24 , 26 , 29 minimizing the radiation adverse effects. Gamma Knife radiosurgery was performed in 75 patients with

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Zjiwar H. A. Sadik, Suan Te Lie, Sieger Leenstra and Patrick E. J. Hanssens

Gamma Knife radiosurgery (GKRS) has been increasingly used as a primary treatment for PCMs during the past decade, 20 , 24 , 26 , 27 , 36 , 44 , 51 , 60 especially for patients with small tumors (< 3 cm) or elderly patients who may not be able to tolerate surgery due to medical comorbidities. Based on our own experience, GKRS can achieve significant volumetric tumor decrease, resulting in decreased pressure on CNs and symptom improvement. In the present study, we present qualitative volumetric changes after primary GKRS for PCM and relate these to clinical symptoms

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Youlin Ge, Dong Liu, Zhiyuan Zhang, Yanhe Li, Yiguang Lin, Guokai Wang, Yongqing Zong and Enhu Liu

radiation beyond the planning target volume reduces long-term radiation-related complications. Gamma Knife radiosurgery (GKRS) is now increasingly used for the treatment of intracranial meningiomas due to its precise positioning of intracranial lesions. This is a single-center outcome study of the midterm efficacy of GKRS in the treatment of benign intracranial meningiomas. Methods Patient Population This cohort was composed of 130 patients with intracranial WHO grade I meningiomas who underwent GKRS at the Second Hospital of Tianjin Medical University between May 2012

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Diogo Cordeiro, Zhiyuan Xu, Chelsea E. Li, Christian Iorio-Morin, David Mathieu, Nathaniel D. Sisterson, Hideyuki Kano, Luca Attuati, Piero Picozzi, Kimball A. Sheehan, Cheng-chia Lee, Roman Liscak, Jana Jezkova, L. Dade Lunsford and Jason Sheehan

to 20 years after BA. 30 , 31 , 35 In 1958, Dr. Don Nelson made the first description of NS. He described a case of a woman who underwent BA for CD and 3 years later experienced a triad of high plasma level of ACTH, skin hyperpigmentation, and a pituitary tumor. 24 Given the ineffectiveness of medical management and relatively low cure rates of surgical intervention alone, ionizing radiation has been used in the management of NS. 8 Small series and largely single-center NS studies published indicate that Gamma Knife radiosurgery (GKRS) appears to be the most

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Hirotaka Hasegawa, Shunya Hanakita, Masahiro Shin, Mariko Kawashima, Taichi Kin, Wataru Takahashi, Yuichi Suzuki, Yuki Shinya, Hideaki Ono, Masaaki Shojima, Hirofumi Nakatomi and Nobuhito Saito

arteriovenous malformation radiosurgery . Neurosurgery 35 : 585 – 591 , 1994 7808600 10.1227/00006123-199410000-00002 22 Kwon Y , Jeon SR , Kim JH , Lee JK , Ra DS , Lee DJ , : Analysis of the causes of treatment failure in Gamma Knife radiosurgery for intracranial arteriovenous malformations . J Neurosurg 93 ( Suppl 3 ): 104 – 106 , 2000 11143225 10.3171/jns.2000.93.supplement_3.0104 23 Lee WR , Hanks GE , Hanlon AL , Schultheiss TE , Hunt MA : Lateral rectal shielding reduces late rectal morbidity following high dose three

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Nan Zhang, Li Pan, Bin Jiang Wang, En Min Wang, Jia Zhong Dai and Pei Wu Cai

cerebrovascular malformations and develop in approximately 0.4 to 0.8% of the population. 9 Gamma knife radiosurgery had already been used for cavernous hemangiomas before 1990. 12 Kondziolka, et al., 7 had suggested that GKS could reduce the annual rate of hemorrhage. A high incidence of adverse radiation effects after GKS for cavernous hemangiomas had also been reported, 4 and radiosurgery for cavernous hemangiomas remains controversial. 1, 2 A Leksell gamma knife unit was installed at our institution in 1993. By 1996, we had become concerned that the incidence of