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Lilyana Angelov, Alireza M. Mohammadi, Elizabeth E. Bennett, Mahmoud Abbassy, Paul Elson, Samuel T. Chao, Joshua S. Montgomery, Ghaith Habboub, Michael A. Vogelbaum, John H. Suh, Erin S. Murphy, Manmeet S. Ahluwalia, Sean J. Nagel and Gene H. Barnett

date, to our knowledge, only 3 other studies (from 2 centers in Japan) have been published describing the use of SSRS in the management of brain metastases. 24 , 74 , 75 In this article, we present the largest series in the literature (63 LBM) evaluating the impact of 2-staged SRS (2-SSRS) for brain metastases ≥ 2 cm. The purpose of this study was to perform a volumetric assessment of the response of LBM to this treatment strategy in terms of local control (LC) rates and treatment-related toxicity, as well as to determine the impact of 2-SSRS on overall survival (OS