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  • Journal of Neurosurgery: Spine x
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David S. Ditor, Sunil John, Jason Cakiroglu, Colin Kittmer, Paula J. Foster and Lynne C. Weaver

efficacy of neuroprotective or neuroregenerative strategies. Traditionally, many investigators have relied on histological techniques to estimate lesion size after experimental SCI, with the Cavalieri method being perhaps the most commonplace. 10–12 , 14 , 15 In brief, the Cavalieri method of lesion volume estimation involves serial sectioning of the injured spinal cord, either transversely or longitudinally, and then staining of the sections to differentiate the spared tissue from the lesion. The area of the lesion is then determined for each serial section, and the

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Da Liu, Jun Sheng, Hong-hua Wu, Xia Kang, Qing-yun Xie, Yang Luo, Jiang-jun Zhou and Wei Zheng

volume of PMMA used specifically in severely osteoporotic lumbar vertebrae. In a previous study, Liu et al. compared screw stability with several different volumes of PMMA in traditional augmentation of full-length screws in severely osteoporotic lumbar vertebrae. 19 The study showed a significant positive correlation between screw stability and volume of PMMA, and the authors suggested that 3.0 mL is the optimal volume of PMMA. That study was focused on only the relationship between PMMA volume and screw fixation strength, while no studies have focused on the

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Andrew J. Bishop, Randa Tao, B. Ashleigh Guadagnolo, Pamela K. Allen, Neal C. Rebueno, Xin A. Wang, Behrang Amini, Claudio E. Tatsui, Laurence D. Rhines, Jing Li, Eric L. Chang, Paul D. Brown and Amol J. Ghia

perhaps it is related to treatment delivery. There is an interesting philosophical and arguably incongruent difference in the therapeutic approach between highly conformal SSRS and the wide-margin, large-volume conventional fractions used for primary sarcomas. 9 , 15 , 27 Given the propensity of primary sarcomas to recur in the soft tissue when inadequate radiation field margins are used, it may be necessary to modify SSRS treatment fields for this histology in the metastatic setting. To better understand the efficacy of SSRS for metastatic sarcomas, we reviewed our

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Michael W. Chan, Isabelle Thibault, Eshetu G. Atenafu, Eugene Yu, B. C. John Cho, Daniel Letourneau, Young Lee, Albert Yee, Michael G. Fehlings and Arjun Sahgal

modest at best and represent an area for improvement. 5 , 8 In the limited literature on postoperative spine SBRT, the rates of local control are highly promising, as 1-year local control rates of approximately 80% to 90% have been reported. 1 , 6 , 7 Surgery for spinal metastases is often performed for decompression of the spinal cord and involves resection of epidural disease. However, a major area of uncertainty is related to the most appropriate clinical target volume (CTV) for postoperative spine SBRT. Specific to intact metastases, the International Spine

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Takahito Fujimori, Motoki Iwasaki, Yukitaka Nagamoto, Takahiro Ishii, Hironobu Sakaura, Masafumi Kashii, Hideki Yoshikawa and Kazuomi Sugamoto

. We developed a unique technique to evaluate growth three-dimensionally using multidetector CT scanning. We then conducted a study to determine the validity of our technique. Methods Data Source We evaluated thin-slice CT volume data, available at more than 2-year intervals, that had been obtained in 5 patients. All patients had a history of surgery for cervical OPLL; we had access to CT volume data for OPLL before and after surgery for all of them. For all patients, an open-door laminoplasty was performed, using 2 graft bones as spacers. The CT scans were

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Kazuhiro Hasegawa, Ko Kitahara, Haruka Shimoda and Toshiaki Hara

volume is evidence of spinal instability. Methods The IOM system comprises spinous process holders (Gi-5, Mizuhoikakikai), a motion generator (RC-RSW-L-50-S, IAI Corp.), and a personal computer. The 2 holders firmly grip adjacent spinous processes. A cyclic displacement in a single direction at a speed of 2.0 mm/second is generated to the tips of the holders with a maximum displacement of 15.0 mm from the neutral position. Neutral position is defined as the position in which no load is recorded between the tips of the holders. Load at the tip of the caudal

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Payam Mousavi, Sandra Roth, Joel Finkelstein, Gordon Cheung and Cari Whyne

, 8–10 To date, there has been little research conducted to investigate and quantify factors leading to the higher rate of complication seen clinically in the treatment of metastatic compared with osteoporotic disease along with percutaneous vertebroplasty. The objective of this study was to quantify volumetrically cement distribution in patients with osteoporotic and metastatic lesions undergoing percutaneous vertebroplasty and to establish whether differences exist in leakage and percentage of cement volume with regard to their potential clinical significance at

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Ashley R. Poynton, Fengyu Zheng, Emre Tomin, Joseph M. Lane and G. Bryan Cornwall

polylactide barrier on posterolateral fusion mass volume in a rabbit spinal fusion model. 3 We hypothesize that protected bone regeneration strategies can be used to enhance posterolateral fusion mass volume. Materials and Methods Animal Model Twenty adult New Zealand white rabbits (weight 4.5–5 kg) were obtained following Institutional Animal Care and Use Committee approval. Four study groups were used, each containing five animals. All animals underwent bilateral posterolateral L5–6 intertransverse fusion. 3 Surgical Technique General anesthesia was induced

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Peter C. Gerszten, Steven A. Burton, Cihat Ozhasoglu, William J. Vogel, William C. Welch, Joseph Baar and David F. Friedland

prior radiation exposure and those with lesions close to the spinal cord. The prescription dose was independent of the tumor volume. In each case, the spinal cord and/or cauda equina was outlined as a critical structure. At the level of the cauda equina, the spinal canal was outlined. Therefore, at the level of the cauda equina, the critical volume is the entire spinal canal and not actual neural tissue. The maximum dose was defined as that delivered to a single pixel. Several patients had previously undergone resection and placement of stabilizing hardware; thus

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Marina Boido, Diego Garbossa and Alessandro Vercelli

-μm-thick sections (total spinal cord segment 1700 μm in length) was drawn at the computer using the Neurolucida software program (MicroBright-Field, Inc.), and the volume obtained was analyzed with Neurolucida Explorer (MicroBrightField, Inc.). The lesion volume was then expressed as a percentage of the total volume of the segment analyzed. Western Blot Analysis An additional 8 mice were subjected to the same procedure and injection of NPs (4 mice) or vehicle alone (4 mice) as described above in Surgery and Cell Injection Procedures . All 8 of these mice