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Jessica A. Wilden, Kurt Y. Qing, Sheketha R. Hauser, William J. McBride, Pedro P. Irazoqui and Zachary A. Rodd

with health care expenses, law enforcement costs, property loss, and reduced productivity, contribute to the considerable economic burden of alcoholism, 58 which is estimated to be approximately 2% of the United States gross domestic product. 52 Traditional treatments for alcoholism suffer from high rates of noncompliance, variable effectiveness, and serious side effects. An estimated 45%–75% of treated alcoholics will relapse within 3 years, 1 , 3 , 10 indicating that alcoholism can be a chronic and recurring illness, and there is a need for better therapies

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John S. Meyer, Yasuhisa Kitagawa, Norio Tanahashi, Hisao Tachibana, Prasab Kandula, David A. Cech, Guy L. Clifton and James E. Rose

other risk factors for dementia were present (such as hypertension, chronic alcoholism, or early senile dementia of the Alzheimer type), the type of shunt placed, and any complications of shunting. In six cases the etiology of NPH was not apparent and these cases were classified as idiopathic, two cases were secondary to subarachnoid hemorrhage (SAH), one occurred subsequent to removal of a tentorial meningioma with treated ependymal and meningeal infection, and one was secondary to congenital aqueductal stenosis without increased intracranial pressure but with long

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Rabih Aboukais, Caroline Loiez, Xavier Leclerc, Philippe Bourgeois, Frederic Wallet, Tomas Menovsky and Jean-Paul Lejeune

treatment was 54 years (range 31–70 years). Ten patients had a ruptured aneurysm and 20 had an unruptured aneurysm. The mean diameter of all aneurysms was 8.5 mm (range 2.5–50 mm). Patients With a Ruptured Aneurysm In patients with a ruptured aneurysm (n = 10), hypertension was present in 7 patients and hyperlipidemia in 1. Seven patients were smokers. Chronic alcoholism was found in 2 patients. Multiple intracranial aneurysms were present in 5 patients. Polycystic kidney disease was present in 1 patient. The WFNS score was I in 3 patients, II in 3 patients, III in 1

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William C. Newman, Dan W. Neal and Brian L. Hoh

, alcoholism, perivascular disease, tobacco use, hypothyroidism, depression, and hypercholesterolemia (p < 0.05 for all). Predictive Model The statistically significant comorbidities were weighted based on their relative impact on patient outcomes to create a comorbidity index (see Table 3 for results). Individual scores ranged from −2 to 7, with positive scores denoting increased odds of poor outcome and negative scores denoting an inverse relationship with poor outcome. TABLE 3. Comorbidity scoring index Comorbidity Point Score p Value

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Po-Chou Liliang, Kuo-Sheng Hung, Ching-Hsiao Cheng, Han-Jung Chen, Ikuho Ohta and Chun-Chung Lui

This 66-year-old man with uncontrolled diabetes mellitus and alcoholism was transferred to our hospital because he was experiencing dizziness and right hemiplegia that had developed suddenly over a 3-day period. A computerized tomography (CT) scan of the brain obtained at another hospital revealed a multiloculated rim-enhancing space-occupying lesion, approximately 6 cm in diameter, in the left parietal region ( Fig. 1 left ). On the day of admission the patient's Glasgow Coma Scale (GCS) score deteriorated from 14 to 6. A repeated CT scan revealed a 6-cm

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reported. This 58-year-old man presented with a 1-year history of increasing weakness and numbness of the legs and gait impairment. On clinical examination, he showed marked weakness, mild spasticity, and decreasing superficial and deep sensation of the legs, with ataxospastic gait. He suffered from hepatic cirrhosis caused by alcoholism. At the time of his hospitalization in October, 1980, we could not carry out computerized tomography (CT) scanning of the spine. However, traditional neuroradiological investigations were able to clear up the diagnosis. Plain spine

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Kewal K. Jain

mm craniotomy, plastic coating of aneurysm, 1973 no relief of headaches TABLE 2 Results in three nontreated patients Case No. Age, Sex Clinical Features Aneurysm Location, Size Follow-up 13 50 F headaches, alcoholism grand mal seizures lt middle cerebral, 1.5 cm; diagnosed 1970 still alive, no change in clinical status 14 69 F sudden onset lt headache with lt pupil larger than rt, hypertension bil post communicating, lt 5 mm, rt 3 mm; diagnosed 1969 no recurrence of headache

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Craig J. McClain, Diana L. Twyman, Linda G. Ott, Robert P. Rapp, Phillip A. Tibbs, Jane A. Norton, Edward J. Kasarskis, Robert J. Dempsey and Byron Young

night blindness and hypogonadism. Alcoholism Clin Exp Res 3 : 135 – 141 , 1979 McClain CJ, Van Thiel DH, Parker S, et al: Alterations in zinc, vitamin A, and retinol-binding protein in chronic alcoholics: a possible mechanism for night blindness and hypogonadism. Alcoholism Clin Exp Res 3: 135–141, 1979 45. Miller SL : The metabolic response to head injury. S Afr Med J 65 : 90 – 91 , 1984 Miller SL: The metabolic response to head injury. S Afr Med J 65: 90–91, 1984 46. Pories WJ , Henzel JH

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Abdul Rasul Sadik, Masazumi Adachi and Joseph Ransohoff

hemiparesis cleared rapidly. Marked improvement in his organic mental changes was noted. Roentgenogram of the skull showed the clips in contact. An electroencephalogram on July 28, 1962 was reported as normal. Psychiatric evaluation was that of a mild organic mental syndrome secondary to chronic alcoholism and head trauma. He was discharged from the hospital on Aug. 8, 1962, ambulatory, and was fully rational with no focal neurological deficit. Discussion Clark and Gooddy 2 classified ruptured intracranial aneurysm as (1) rupture resulting in extensive

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Avital Fast, Malvina Alon, Shmuel Weiss and Freddy R. Zer-Aviv

changes in pharmacotherapy. Acta Orthop Scand 53: 853–856, 1982 9. Habermann ET , Cristofaro RL : Avascular necrosis of bone as a complication of renal transplantation. Semin Arthritis Rheum 6 : 189 – 206 , 1976 Habermann ET, Cristofaro RL: Avascular necrosis of bone as a complication of renal transplantation. Semin Arthritis Rheum 6: 189–206, 1976 10. Hungerford DS , Zizic TM : Alcoholism associated ischemic necrosis of the femoral head. Early diagnosis and treatment. Clin Orthop 130 : 144