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Stefan G. Scheib, Stefano Gianolini, Dieter Haller, Georgios N. Wellis and Jean Siegfried

A fter GKS, most patient follow-up studies include clinical status determined by a physician and CT and MR imaging studies. Radiological examinations during follow up are used to quantify the visible lesion volume, which permits early recognition of growth of the lesion and aids decisions concerning further therapeutic intervention. 10 It also permits definition of therapeutic success and the observation of certain complications that follow GKS. Usually, the diameters of the lesion are measured in a more or less arbitrary fashion or the extent along the

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Xavier Vasques, Laura Cif, Olivier Hess, Sophie Gavarini, Gerard Mennessier and Philippe Coubes

D eep brain stimulation of the GPi is now a commonly used and effective treatment for primary DDSs. 5–7 , 12 , 14 A wide range of factors can influence the outcome of DBS including clinical, anatomical, surgical, and electrical variables. To give prominence to one of these factors, we decided to compare the actual GPi volumes as well as stimulated GPi volumes between highly and less improved patients with primary DDS. The stimulated GPi volume is quantified by calculating each electric field value generated by the DBS lead. The stereotactic protocol

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Kristin J. Weaver, Matthew McCord, Dan Neal, Frank Bova, Didier Rajon, Alfredo Quinones-Hinojosa and Maryam Rahman

associated with the need for a VPS in patients with colloid cysts. The VPS rates in colloid cyst patients vary significantly between studies in the literature, and risk factors for the need for permanent CSF diversion are not well described. Increased ventricular size or intraventricular hemorrhage may be associated with an increased need for permanent CSF diversion, although this hypothesis has not been rigorously studied. The objective in the present study was to determine if patient factors such as preoperative ventricular volume or colloid cyst size influenced the

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Ping Zhu, Xianglin L. Du, Angel I. Blanco, Leomar Y. Ballester, Nitin Tandon, Mitchel S. Berger, Jay-Jiguang Zhu and Yoshua Esquenazi

(codeletion of 1p19q and IDH1/2 mutation), and extent of resection (EOR). 24 , 41 Recent studies have reported more favorable survival outcomes in patients with various cancer types treated at academic centers (ACs), and an increasing number of studies have shown volume-outcome relationships in surgical neurooncology, 4 , 9 , 16 , 29 , 39 including glioblastoma. 54 However, little is known about the impact of facility type on LGG outcomes. Several studies have demonstrated an association between EOR and survival, and current data strongly argue in favor of achieving a

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Kenneth Shapiro, Arno Fried, Futoshi Takei and Ira Kohn

between formation and absorption of CSF will occur at a higher CSF pressure resulting in stabilization of ventricular volume. 16, 18 However, many investigations have shown only modest elevations of CSF pressure in hydrocephalic patients who continue to exhibit progressive ventricular dilatation. 3, 5, 11, 20 From these empiric observations, many authors have concluded that this mechanism of compensation does not adequately describe the mechanical events in hydrocephalus. 15–18 Noting that the ventricular enlargement in hydrocephalic infants usually exceeds that

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Ranjodh Singh, Zhiping Zhou, Jamie Tisnado, Sofia Haque, Kyung K. Peck, Robert J. Young, Apostolos John Tsiouris, Sunitha B. Thakur and Mark M. Souweidane

D iffuse intrinsic pontine gliomas (DIPGs) are inoperable and lethal brainstem gliomas that are found in children, with a median age of diagnosis of 6–7 years. 6 DIPGs account for approximately 80% of pediatric brainstem tumors. Despite numerous efforts to improve treatment, the median survival of patients with these tumors is less than 1 year. 6 , 10 Accurately determining DIPG tumor volume is important for therapeutic planning, monitoring disease progression, and measuring tumor response to therapy. 5 , 18 Previous studies using MRI and semiautomated

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Marie-Noëlle Hébert-Blouin, Bahram Mokri, Alexander Y. Shin, Allen T. Bishop and Robert J. Spinner

I n recent years, the syndrome of intracranial hypotension has become well defined and accepted. Patients with intracranial hypotension typically present with postural headaches due to reduced CSF volume. A wide variety of spontaneous, traumatic, and iatrogenic causes affecting the brain and spinal cord leading to CSF hypovolemia have been identified. Surprisingly, only 2 patients with BPI resulting in CSF hypovolemia and intracranial hypotension have been reported, 12 , 14 despite the relatively common pattern of injury and its potential overt source of

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Kenneth Shapiro and Anthony Marmarou

often fatal, rises in pressure represents a critical shortcoming. To circumvent this deficiency, techniques using bolus manipulation of fluid 10 and, more recently, pulse wave analysis 1 have been developed. These techniques can be used to assess neural axis compliance in order to identify patients at risk of sudden increases of ICP. One of these techniques, the pressure-volume index (PVI), which utilizes bolus manipulation of cerebrospinal fluid (CSF), has been developed in this laboratory. The application of PVI testing to the care of head-injured children will be

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Ghaleb A. Ghani, Yung Fong Sung, Michael S. Weinstein, George T. Tindall and Alan S. Fleischer

intracranial pressure (ICP) with boluses of NTG in cats, and stated that this may be a limiting factor in its clinical use. More recently, Dohi, et al. , 4 reported an increase in the lumbar cerebrospinal fluid (CSF) pressure with intravenous boluses of NTG in humans with no neurological disorder. The volume-pressure response (VPR) concept was introduced by Miller, et al. , 9 to evaluate the intracranial compliance. The technique consists of injecting 1 ml of fluid into the lateral ventricle over 1 second and measuring the immediate change in ventricular fluid pressure

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Richard P. Menger, Piyush Kalakoti, Andrew J. Pugely, Anil Nanda and Anthony Sin

initial hospitalization is critical to the delivery of pediatric spinal care. To our knowledge, a comprehensive analysis has not previously been performed of the modifiable and nonmodifiable risk factors associated with the outcomes of initial hospitalization in adolescent patients undergoing deformity correction for idiopathic scoliosis using a large administrative cohort. Further, a thorough assessment of the effect of hospital surgical volume on outcomes is needed for AIS surgery. In the present study, we seek to evaluate hospital and patient factors related to