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Rolf Luft and Herbert Olivecrona

sella turcica). Our interpretation is that the removal of the uterus with its attending ligatures of pelvic veins activated the arteriovenous aneurysm by obliterating some of the draining channels. After hypophysectomy the reduction of blood volume and blood pressure probably reduced the tension in the aneurysm with some relief of pressure on the spinal cord. That chorionepitheliomatous tissue was present in the body at least up to April was shown quite conclusively by the excretion of chorionic gonadotrophic hormone, which after hypophysectomy gradually dropped and

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Rembrandt H. Dunsmore, William Beecher Scoville, Francis Reilly and Benjamin Bradford Whitcomb

. , Goldthwait , J. C. , and Adams , R. D. Changes in brain volume and blood content after experimental concussion. Ann. Surg. , 1943 , 118 : 619 – 633 . White , J. C., Brooks , J. R., Goldthwait , J. C., and Adams , R. D. Changes in brain volume and blood content after experimental concussion. Ann. Surg. , 1943, 118: 619–633. 14. White , J. C. , Verlot , M. , Selverstone , B. , and Beecher , H. K. Changes in brain volume during anesthesia: the effects of anoxia and hypercapnia. Arch

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Paul Lin, Frederick Murtagh, Henry Wycis and Michael Scott

Diodrast 35 per cent. However, the bi-plane stereoscopic unit was not developed when the Diodrast was used and multiple injections, using as high as 20–30 cc. of the contrast medium, were frequently necessary for each patient. This marked difference in dosage may be an important factor in the difference in complications. However, volume for volume Diodrast 35 per cent causes more facial grimacing, eye and head pain than Urokon and usually requires a general anesthetic for satisfactory sequence angiograms; with Urokon 30 per cent we were able to do 50 per cent of our

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Eldon L. Foltz, Fritz L. Jenkner and Arthur A. Ward Jr.

set of data deals with the effects of circulating acetylcholine so produced, and specifically with its possible relation to so-called cerebral swelling. White et al. 14 reported an increase in volume of the concussed cat brain associated with a moderate rise in cisternal pressure within 4 hours of concussion. Acetylcholine is a powerful vasodilator and may alter vascular permeability. It is conceivable that its presence in high concentration may be a factor in this increase in brain volume. Since a marked change in brain volume should cause a change in spinal

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Experimental Studies on the Circulation of the Cerebrospinal Fluid

And Methods of Producing Communicating Hydrocephalus in the Dog

Peter H. Schurr, Robert L. McLaurin and Franc D. Ingraham

symptoms and signs of obstruction. The volume of Pantopaque used is not the operative factor, since there was no enlargement of the ventricles of a dog 5 weeks after a cisternal injection of 6 cc. of the substance. Obstruction in the interpeduncular and neighboring cisterns was produced in dogs by the following method. A polyethylene tube was introduced into the interpeduncular region through a subtemporal craniotomy under intravenous Nembutal anesthesia. The animals were then kept in a prone position while injections of a suspension of 250 mg. of kaolin * in 2 cc. of

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Arnold M. Meirowsky

fibrin foam, secondary thrombosis developed. The same was observed in 1 out of 15 lacerations that were repaired with a muscle stamp. Thrombosis may, of course, have developed in other instances without manifesting itself clinically. It seems that the occurrence of secondary thrombosis depends not so much on the method of repair as on the maintenance of blood volume and pressure before, during and immediately after operation. SUMMARY 1. A group of 112 consecutive cases of dural sinus wounds, incurred in the Korean War during the period September 1950 to

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P. E. Wiklund

reduce the circulating blood volume. COMPOSITION OF SERIES The present series comprises 60 patients, 26 males and 34 females, operated on at the Department of Neurosurgery, Serafimerlasarettet, between January and November 1952. Diagnosis Number of Cases Arterial aneurysm 28 Arteriovenous aneurysm 4 Meningioma 15 Neurinoma 5 Glioma 3 Intracranial metastases 2 Chordoma 1 Jacksonian epilepsy 1 Malignant hypertension (hypophysectomy) 1 The youngest patient was

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W. Eugene Stern

rather crude. The volume of opaque material that is injected varies in its relation to the capacity of the circulatory bed being studied. The pressure with which it is injected is also a variable. These factors must influence the degree of filling of the components of the arterial tree. In view of the known fallibilities of arteriographic techniques in consistently filling the same vessels in repeated injections, we cannot accept single angiographic records as being wholly reliable in reflecting the functional state of arterial cross-over. Although the methods of

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J. Lawrence Pool

during the 15-sec. period of stimulation, often without other effects such as a change in cardiac or respiratory rate. Occasionally, however, blood pressure changes took place after the cessation of stimulation, but in such cases, since temporary apnea also occurred, the delayed alterations in blood pressure may have been secondary to changes in pulmonary circulation. The pulse rate was usually slowed by 10 to 20 beats per min. for a few seconds and occasionally extrasystoles were produced. When a striking increase or decrease in finger volume was indicated by

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Controlled Hypotension

II. A Preliminary Report on “Arfonad”® (RO 2-2222)

Max S. Sadove, Gordon M. Wyant, Gwen Gleave and Paul C. Bucy

position. Thus, when the head is elevated, a further fall of blood pressure can be obtained which will again level off to a plateau despite the administration of more Arfonad. These persons respond to oxygen deficiency with a tachycardia and to an excess of carbon dioxide with hyperpnea and a tendency of the blood pressure to rise again. In the unanesthetized human being the venous pressure remains essentially unchanged, as do electrocardiographic and electroencephalographic tracings. Plethysmographic recordings demonstrate an increase in peripheral pulse volume, as