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Matthew M. Grabowski, Pablo F. Recinos, Amy S. Nowacki, Jason L. Schroeder, Lilyana Angelov, Gene H. Barnett and Michael A. Vogelbaum

, 22 While most within the field of neurooncology agree that maximal resection of the tumor offers the best chance for prolonged survival, the impact of extent of resection (EOR) on survival continues to be a point of discussion. 15 Previous studies have used both CT and MRI to try to determine EOR and its implications for survival in GBM patients. Although there are no definitive prospective studies that have shown that EOR alone alters survival, there is a substantial volume of retrospective literature that has shown that maximizing EOR likely extends time to

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Erlend Aambø Langvatn, Radek Frič, Bernt J. Due-Tønnessen and Per Kristian Eide

I n healthy children, intracranial volume (ICV) doubles by 9 months of age and triples by 6 years of age. 15 Craniosynostosis, first described by Sömmerring in 1791, 24 is a condition resulting from premature closure of calvarial sutures, presenting in newborns and small infants and limiting normal growth of the skull. Most common are the sagittal (scaphocephaly), coronal (plagiocephaly), and metopic (trigonocephaly) synostoses, while the complex cases of multiple-suture closures are less common and often syndromal. Craniosynostosis may cause reduction of the

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Yeon Soo Choo, Joonho Chung, Jin-Yang Joo, Yong Bae Kim and Chang-Ki Hong

S pontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity and mortality. It accounts for 10% to 15% of all strokes. 5 , 8 The most common location of ICH is the basal ganglia. There is no doubt that a large, life-threatening ICH should be evacuated, and an ICH with a volume < 10 cm 3 should be treated medically. However, many studies have compared surgical and medical treatment for ICH with volumes that fall between these absolutes. The International Surgical Trial in Intracerebral Hemorrhage (STICH) concluded that there

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Minoru Hayashi, Hidenori Kobayashi, Yuji Handa, Hirokazu Kawano and Masanori Kabuto

. During the plateau waves, however, the BP usually does not rise, and the patients are often alert and well oriented. 12–15 In this study, we have examined the blood flow and blood volume of both the cerebral hemisphere and the brain stem by means of dynamic computerized tomography (CT) in patients with plateau waves in continuous ICP recordings. By this means, we have attempted to determine if there is a relationship between intracranial hemodynamic changes and clinical symptoms during plateau waves. Clinical Material and Methods Five patients with plateau waves

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Fred Epstein, Gerald Hochwald and Joseph Ransohoff

cats were similar. 2 The CSF absorption rate in acute hydrocephalic cats was only 20% of that in chronic preparations. 2 Moreover, in spite of the decreased intraventricular pressure the mean ventricular size in the chronic cats was twice that in the acute cats. Ventricular volume remained constant up to 10 months in the chronic hydrocephalic cats. In spite of the return of the intraventricular pressure to normal, the CSF absorptive capacity of the chronic hydrocephalic cat was not identical to that noted in the normal one. To initiate absorption in the chronic

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Taek-Hyun Kwon, Youn-Kwan Park, Dong-Jun Lim, Tai-Hyoung Cho, Yong-Gu Chung, Hung-Seob Chung and Jung-Keun Suh

rate, comprising approximately one third of the total. The drainage volumes, which were measured for 5 days after burr-hole craniostomy with closed-system drainage, decreased markedly starting on the 2nd day after the surgery regardless of preoperative CT findings, and then gradually for 5 days ( Fig. 1 ). The mean drainage volume of all patients for 5 days was 320 ml, and the low-density type of CSDH in preoperative CT findings had the largest amount of drainage, with a mean volume of 413 ml, whereas the mixed-density type showed the smallest mean volume, 151 ml

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Ahmed Rawanduzy, Anker Hansen, Thomas W. Hansen and Maiken Nedergaard

appears to be, at least in part, a result of the failure of tissue within the penumbra to repolarize following spontaneous waves of spreading depression. 5 Although these depolarizing waves are generated within ischemic regions, their invasion of neighboring tissue is widespread and can enlarge stroke volume. 10, 15, 18 A key step in understanding why an ischemic infarction expands is to establish why and how waves of spreading depression are generated within ischemic tissue. Recently we demonstrated that an intact gap junction network is required to propagate

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Lorenzo Rinaldo, Brandon A. McCutcheon, Meghan E. Murphy, Daniel L. Shepherd, Patrick R. Maloney, Panagiotis Kerezoudis, Mohamad Bydon and Giuseppe Lanzino

T he surgical clipping of an unruptured intracranial aneurysm (UIA) is a technically challenging and potentially morbidity-producing procedure. 21 Greater institutional experience in the surgical treatment of UIAs has been correlated to improved functional outcome after intervention, 4 , 8 , 15 arguing for the centralization of care at specialized centers. The effect of institutional case volume on the incidence of reportable complications during and after the clipping of UIAs, however, has not been as well defined, and thus the mechanism by which greater

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Ronald Brisman and R. Mooij

relief and medical therapy that did not induce discomfort. The relationship was analyzed between pain relief at 6 and 12 months following GKS and VB20 and VT50, as determined on dose—volume histograms, laterality, presence of MS, age of patient, interval from first symptom to GKS, sex, and previous neurosurgical procedure for TN. In a series of 11 patients, the 4-mm isocenter was placed on the left and right trigeminal nerves so that the 50% isodose line touched the brainstem. The VB20 was calculated on each side. Statistical Analysis Commercially available

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Gerrit J. Bouma, J. Paul Muizelaar, Kuniaki Bandoh and Anthony Marmarou

I t is customary to explain raised intracranial pressure (ICP) after head trauma in terms of volume increases within the intracranial compartment, be it caused by hematoma, cerebrospinal fluid (CSF), tissue water (edema), or cerebral blood volume (CBV). The extent to which such volume changes will translate into changes in pressure depends on the compliance or volume-buffering capacity of the system. Compliance of the craniospinal axis, defined as the change in CSF volume per unit change in pressure, is not constant but increases as pressure rises. 25 The