Search Results

You are looking at 1 - 5 of 5 items for

  • Author or Editor: Zengpanpan Ye x
  • Refine by Access: all x
Clear All Modify Search
Full access

The factors associated with hemorrhagic presentation in children with untreated brain arteriovenous malformation: a meta-analysis

Xiaolin Ai, Zengpanpan Ye, Jianguo Xu, Chao You, and Yan Jiang

OBJECTIVE

Rupture of arteriovenous malformations (AVMs) would result in high mortality and prevalence of disability in pediatric patients. Decisions regarding the treatment of AVMs need to weigh the risk of rupture over the course of their natural history against the possibility of creating a lesion during treatment. Multiple factors have been proposed to predict hemorrhagic presentation of pediatric patients with AVMs. The aim of this meta-analysis was to evaluate the predictors of hemorrhagic presentation in pediatric patients with AVMs.

METHODS

The authors searched the PubMed and EMBASE databases. Studies reporting the predictors of hemorrhagic presentation in children with untreated brain AVMs were included. The predictive ability of identified predictors was assessed by odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS

A higher risk of hemorrhagic presentation was found in AVMs with smaller size (< 3 cm, OR 2.97, 95% CI 1.94–4.54, p < 0.00001), deep venous drainage (OR 2.28, 95% CI 1.55–3.36, p < 0.0001), a single draining vein (OR 2.23, 95% CI 1.27–3.92, p = 0.005), a single feeder (OR 3.72, 95% CI 1.31–10.62, p = 0.01), a deep location (OR 1.82, 95% CI 1.22–2.72, p = 0.004), an infratentorial location (OR 2.25, 95% CI 1.19–4.26, p = 0.01), and diffuse morphology (OR 8.94, 95% CI 3.01–26.55, p < 0.0001). In addition, the AVMs with draining vein ectasia (OR 0.35, 95% CI 0.13–0.97, p = 0.04) and high Spetzler-Martin (SM) grade (OR 0.53, 95% CI 0.36–0.78, p = 0.001) had a lower risk of hemorrhagic presentation in pediatric patients.

CONCLUSIONS

Smaller AVMs, deep venous drainage, a single draining vein, a single feeder, deep/infratentorial location, diffuse morphology, and high SM grade were identified as positive predictors for hemorrhagic presentation. Particularly, patients with diffuse AVMs have a higher risk of hemorrhagic presentation than other factors and may need active treatments. However, factors such as age, sex, draining vein stenosis, and associated aneurysms were not associated with hemorrhagic presentation.

Full access

Letter to the Editor. The surgical outcomes of symptomatic moyamoya disease in adults

Zengpanpan Ye, Xiaolin Ai, and Chao You

Free access

Letter to the Editor. Complications from the use of flow-diverting devices

Zengpanpan Ye, Xiaolin Ai, and Chao You

Full access

Letter to the Editor. Cyst formation after stereotactic radiosurgery for brain AVMs

Zengpanpan Ye, Xiaolin Ai, and Chao You

Full access

Letter to the Editor. Volume-staged vs dose-staged SRS for large brain AVMs

Zengpanpan Ye, Xiaolin Ai, and Chao You