✓ A 42-year-old woman exhibited reproducible paroxysmal nystagmus on looking upward while standing, or on turning her head to the right while reclining. She also experienced vertigo with these postural maneuvers. These neurological findings were attributed to brain-stem ischemia secondary to arteriosclerotic occlusive disease of the left subclavian and innominate arteries. Surgical restoration of normal blood flow in these extracranial vessels was associated with complete remission of the nystagmus and vertigo.
Surendra M. Gulati, James E. Pugh, Walter M. Whitehouse Jr. and James C. Stanley
Ronald G. Clark, Thomas H. Milhorat, Walter C. Stanley and Giovanni Di Chiro
✓ The injection of Pantopaque into the ventricles of normal and hydrocephalic dogs produced a variety of acute and chronic pathological changes. Multiple granulomatous lesions developed in the ventricular wall and the surrounding brain parenchyma, choroid plexus, cranial nerves, and arachnoid membrane. Adhesions formed in several areas of the ventricles, and Pantopaque became encysted in the third ventricle and tips of the temporal horns. In general there were more serious changes in the animals that had a greater degree of hydrocephalus. Relatively mild lesions were noted in normal animals.
Harvey S. Levin, Stephen C. Lippold, Arnold Goldman, Stanley Handel, Walter M. High Jr., Howard M. Eisenberg and David Zelitt
✓ In a prospective investigation of neurobehavioral functioning in young boxers, 13 pugilists and 13 matched control subjects underwent tests of attention, information-processing rate, memory, and visuomotor coordination and speed. The results disclosed more proficient verbal learning in the control subjects, whereas delayed recall and other measurements of memory did not differ between the two groups. Reaction time was faster in the boxers than in the control subjects, but no other differences were significant. Ten subjects in each group were retested 6 months later and exhibited improvement in their neuropsychological performance as compared to baseline measurements. However, there were no differences in scores between the boxers and the control subjects at the follow-up examination or in the magnitude of improvement from baseline values. Magnetic resonance imaging, which was performed in nine of the boxers, disclosed normal findings.
Harvey S. Levin, David Williams, Marsha J. Crofford, Walter M. High Jr., Howard M. Eisenberg, Eugenio G. Amparo, Faustino C. Guinto Jr., Zvi Kalisky, Stanley F. Handel and Arnold M. Goldman
✓ Magnetic resonance (MR) imaging was performed in 94 patients who sustained closed head injury of varying severity. Results of MR studies obtained after the intensive care phase of treatment disclosed that intracranial lesions were present in about 88% of the patients. Consistent with the centripetal model of progressive brain injury proposed in 1974 by Ommaya and Gennarelli, the depth of brain lesion was positively related to the degree and duration of impaired consciousness. Further analysis indicated that the relationship between depth of brain lesion and impaired consciousness could not be attributed to secondary effects of raised intracranial pressure or to the size of intracranial lesion(s).