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Prof. Dr. med. Rudolf Fahlbusch

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Rudolf Fahlbusch and Amir Samii

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Tomoki Todo and Rudolf Fahlbusch

✓ In order to elucidate some of the signal transduction processes in human meningioma cells, the authors studied the effect of epidermal growth factor (EGF) and bromocriptine on inositol phospholipid hydrolysis, using low-passage human meningioma cells in culture. Epidermal growth factor is a well-studied mitogenic factor for meningioma cells, whereas bromocriptine is known to have an inhibitory effect on meningioma cell proliferation. The addition of EGF to meningioma cells caused stimulation of inositol phosphate accumulation in a dose-dependent manner at 60 minutes posttreatment, with the maximum effect (120% to 167% of control) achieved at a concentration of 10 ng/ml. Extraction of separate inositol phosphates revealed that inositol monophosphate (IP1) and inositol bisphosphate (IP2), but not inositol trisphosphate (IP3), accounted for the increase at 60 minutes. Kinetic analysis of EGF-stimulated inositol phospholipid hydrolysis showed that a sharp and transient increase in IP3 from 5 to 12 minutes post-EGF and a transient but more gradual increase in IP2 from 2 to 12 minutes post-EGF were followed by a gradual and steady increase in IP1, which was significantly greater than control after 5 minutes. On the other hand, long-term studies showed a down-regulation of inositol phosphate accumulation (a 64% decrease vs. control) after 7 days of treatment with EGF (10 ng/ml). Bromocriptine (5 µM) exhibited no significant effect on inositol phosphate accumulation at 60 minutes in four of five meningiomas studied. However, of two meningiomas studied with bromocriptine in combination with EGF, both showed a significant additive increase in inositol phosphate accumulation compared to those treated with EGF alone. The results suggest a close involvement of inositol phospholipid turnover in human meningioma cells in response to mitogenic stimulation by EGF.

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Rudolf Fahlbusch and Werner Schott

Object. The authors reviewed 47 cases of suprasellar meningiomas with special attention to ophthalmological and endocrinological outcomes.

Methods. All patients underwent surgery performed via a unilateral pterional approach between January 1983 and January 1998. Ophthalmological and endocrinological examinations were performed before the operation as well as 1 week and 3 months postoperatively. A special scoring system was adopted to quantify the extent of ophthalmological disturbances. Complete tumor resection was possible in all but one patient. There were no fatalities and the rate of visual improvement was 80%. The best prognoses were found in patients younger than 50 years and in patients in whom the duration of symptoms was less than 1 year. Before surgery, tumor-related endocrine disturbances were present in only three women who suffered from secondary hypogonadism; two of these patients recovered after surgery. Postoperatively, no patient needed replacement therapy for pituitary dysfunction. The overall tumor recurrence rate was 2.1% (one of 47 cases). For patients in whom long-term (> 5 years) follow-up data were available, the recurrence rate was 4.2% (one of 24 cases).

Conclusions. In this series, complete resection of suprasellar meningiomas was possible through a unilateral pterional craniotomy and was associated with a low morbidity rate and no deaths.

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Hussam Metwali, Venelin Gerganov, and Rudolf Fahlbusch


Preservation of the pituitary stalk and its vasculature is a key step in good postoperative endocrinological outcome in patients with craniopharyngiomas. In this article, the authors describe the surgical technique of medial optic nerve mobilization for better inspection and preservation of the pituitary stalk.


This operative technique has been applied in 3 patients. Following tumor exposure via a frontolateral approach, the pituitary stalk could be seen partially hidden under the optic nerve and the optic chiasm. The subchiasmatic and opticocarotid spaces were narrow, and tumor dissection from the pituitary stalk under direct vision was not possible. The optic canal was therefore unroofed, the falciform ligament was incised, and the lateral part of the tuberculum sellae was drilled medial to the optic nerve. The optic nerve could be mobilized medially to widen the opticocarotid triangle, which enhanced visualization of and access to the pituitary stalk.


By using the optic nerve mobilization technique, the tumor could be removed completely, and the pituitary stalk and its vasculature were preserved in all patients. In 2 patients, vision improved after surgery, while in 1 patient it remained normal, as it was before surgery. The hormonal status remained normal after surgery in 2 patients. In the patient with preoperative hormonal deficiencies, improvement occurred early after surgery and hormonal levels were normal after 3 months. No approach-related complications occurred.


This early experience shows that this technique is safe and could be used as a complementary step during microsurgery of craniopharyngiomas. It allows for tumor dissection from the pituitary stalk under direct vision. The pituitary stalk can thus be preserved without jeopardizing the optic nerve.

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Johann Romstöck, Christian Strauss, and Rudolf Fahlbusch

Object. Electromyography (EMG) monitoring is expected to reduce the incidence of motor cranial nerve deficits in cerebellopontine angle surgery. The aim of this study was to provide a detailed analysis of intraoperative EMG phenomena with respect to their surgical significance.

Methods. Using a system that continuously records facial and lower cranial nerve EMG signals during the entire operative procedure, the authors examined 30 patients undergoing surgery on acoustic neuroma (24 patients) or meningioma (six patients). Free-running EMG signals were recorded from muscles targeted by the facial, trigeminal, and lower cranial nerves, and were analyzed off-line with respect to waveform characteristics, frequencies, and amplitudes. Intraoperative measurements were correlated with typical surgical maneuvers and postoperative outcomes.

Characteristic EMG discharges were obtained: spikes and bursts were recorded immediately following the direct manipulation of a dissecting instrument near the cranial nerve, but also during periods when the nerve had not yet been exposed. Bursts could be precisely attributed to contact activity. Three distinct types of trains were identified: A, B, and C trains. Whereas B and C trains are irrelevant with respect to postoperative outcome, the A train—a sinusoidal, symmetrical sequence of high-frequency and low-amplitude signals—was observed in 19 patients and could be well correlated with additional postoperative facial nerve paresis (in 18 patients).

Conclusions. It could be demonstrated that the occurrence of A trains is a highly reliable predictor for postoperative facial palsy. Although some degree of functional worsening is to be expected postoperatively, there is a good chance of avoiding major deficits by warning the surgeon early. Continuous EMG monitoring is superior to electrical nerve stimulation or acoustic loudspeaker monitoring alone. The detailed analysis of EMG-waveform characteristics is able to provide more accurate warning criteria during surgery.

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Christian Strauss, Elke Lütjen-Drecoll, and Rudolf Fahlbusch

✓ A safe paramedian approach to the rhomboid fossa for surgical treatment of intrinsic brainstem lesions is based on detailed knowledge of the morphometric anatomy of superficially located motor structures. The morphometry of the rhomboid fossa is described in this report on the basis of histological studies conducted in six human brainstem specimens, with special emphasis on the colliculus facialis and the trigona nervi hypoglossi and vagi. Morphometric data include analysis of shrinkage factors in each specimen. The colliculus is a landmark for the nervus facialis, oculomotor nuclei, and the paramedian pontine reticular formation. In the surgeon's view from the posterior approach, the colliculus covers an area of 5.7 mm in the mediolateral and 6.8 mm in the craniocaudal direction and is located 0.6 mm lateral to the median sulcus. The fibers of the nervus facialis come as close as 0.2 mm to the surface of the fourth ventricle. The colliculus is located 15.7 mm above the obex. The trigona nervi hypoglossi and vagi cover a rectangular area measuring 3.1 by 6.5 mm and serve as a landmark for lower cranial nerve nuclei. These nuclei are located 0.3 mm lateral to the midline. An area with a maximum extension of 0.9 cm between the colliculus and trigona can be used for an infracollicular paramedian approach. The same applies to a supracollicular approach cranial to the colliculus and caudal to the fibers of the nervus trochlearis within the medullary velum, with a craniocaudal extension of 4 mm. Superficial motor nuclei and fibers can be identified by neurophysiological mapping, which helps to define safe surgical corridors into the rhomboid fossa, thus reducing functional morbidity caused by the operative approach in intrinsic pontine and pontomedullary lesions.

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Christian Strauss, Johann Romstöck, and Rudolf Fahlbusch

Object. The authors describe their technique of electrophysiological mapping to assist pericollicular approaches into the rhomboid fossa.

Methods. Surgical approaches to the rhomboid fossa can be optimized by direct electrical stimulation of superficially located nuclei and fibers. Electrophysiological mapping allows identification of facial nerve fibers, nuclei of the abducent and hypoglossal nerves, motor nucleus of the trigeminal nerve, and the ambiguous nucleus. Stimulation at the surface of the rhomboid fossa performed using the threshold technique allows localization above the area that is located closest to the surface. Simultaneous bilateral electromyographic (EMG) recordings from cranial motor nerves obtained during stimulation document the selectivity of evoked EMG responses. With respect to stimulation parameters and based on morphometric measurements, the site of stimulation can be assumed to be the postsynaptic fibers at the axonal cone. Strict limitation to 10 Hz with a maximum stimulation intensity not exceeding 2 mA can be considered safe. Direct side effects of electrical stimulation were not observed.

Conclusions. Electrical stimulation based on morphometric data obtained on superficial brainstem anatomy defines two safe paramedian supra- and infracollicular approaches to the rhomboid fossa and is particulary helpful in treating intrinsic brainstem lesions that displace normal anatomical structures.